Our primary objective was to determine the proportion of the population able to achieve acute cerebrovascular care in emergency stroke systems (ACCESS) in the United States. In addition, we examined how policy changes, including allowing ground ambulances to cross state lines and allowing air ambulances to transport patients from the prehospital setting to primary stroke centers (PSCs), would affect population access to stroke care. Design: Data were obtained via the US Census Bureau, The Joint Commission, and the Atlas and Database of Air Medical Services. Driving distances, ambulance driving speeds, and prehospital times were estimated using validated models and adjusted for population density. Access was determined by summing the population that could reach a PSC within the specified time intervals.