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Maret, Susan

doi:10.5260/chara.13.4.26

Cited by 11 publications

(16 citation statements)

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“…Meanwhile, zinc is crucial for RA induced neuronal differentiation . Similarly to iron, zinc is a cofactor promoting multiple enzymatic reactions in metabolism and epigenetics . Supplementation of zinc increases rates of mitochondrial electron transport and oxidative phosphorylation and the enzymatic activity of succinate dehydrogenase, glutamate dehydrogenase, cytochrome c oxidase, and ATPase .…”

Section: Micronutrients Enhance Neuronal Metabolism During the Differmentioning

confidence: 99%

“…[72] Similarly to iron, zinc is a cofactor promoting multiple enzymatic reactions in metabolism and epigenetics. [73] Supplementation of zinc increases rates of mitochondrial electron transport and oxidative phosphorylation and the enzymatic activity of succinate dehydrogenase, glutamate dehydrogenase, cytochrome c oxidase, and ATPase. [74] Moreover, zinc can affect the activity of transcription factors such as CREB, which is a critically important transcription factor for mitochondrial related genes (like ND2, ND4, and ND5) and neuronal differentiation.…”

Section: Micronutrients Enhance Neuronal Metabolism During the Differmentioning

confidence: 99%

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Dietary Micronutrients Promote Neuronal Differentiation by Modulating the Mitochondrial‐Nuclear Dialogue

Xie

Sheppard

2018

BioEssays

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The metabolic requirements of differentiated neurons are significantly different from that of neuronal precursor and neural stem cells. While a re-programming of metabolism is tightly coupled to the neuronal differentiation process, whether shifts in mitochondrial mass, glycolysis, and oxidative phosphorylation are required (or merely consequential) in differentiation is not yet certain. In addition to providing more energy, enhanced metabolism facilitates differentiation by supporting increased neurotransmitter signaling and underpinning epigenetic regulation of gene expression. Both epidemiological and animal studies demonstrate that micronutrients (MNs) significantly influence many aspects of neonatal brain development, particularly neural migration and survival, neurite outgrowth, and process maturation. Here we review recent insights into the importance of metabolic reprogramming in neuronal differentiation, before considering evidence that micronutrient signaling may be key to regulating these processes.

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Section: Micronutrients Enhance Neuronal Metabolism During the Differmentioning

confidence: 99%

Section: Micronutrients Enhance Neuronal Metabolism During the Differmentioning

confidence: 99%

Dietary Micronutrients Promote Neuronal Differentiation by Modulating the Mitochondrial‐Nuclear Dialogue

Xie

Sheppard

2018

BioEssays

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“…In this case, the p K d of a metal‐cation‐binding ligand defines pM 2+ for metal buffering, thus the concentration of zinc ions is described as a zinc potential −log[Zn 2+ ]=pZn 2+ . The term buffering in relation to zinc means specific local concentration . The majority of molecular zinc buffering capacity is based on cysteine‐containing ligands, for example, in the above‐mentioned metallothioneins.…”

Section: Human Zinc Homeostasismentioning

confidence: 99%

“…Zinc affinities for protein ligands within the cell are in the range of picomolar, thus concentration of free zinc is proportionally low, around tens to hundreds picomolar . On the other hand, total zinc concentration in the cell is around six orders of magnitude higher . Local changes of free zinc provide a way to control cellular processes, since zinc is in many cases a key factor in information transfer within cells and between cells.…”

Section: Human Zinc Homeostasismentioning

confidence: 99%

Zinc Homeostasis at the Bacteria/Host Interface—From Coordination Chemistry to Nutritional Immunity

Wątły

Potocki

Rowińska‐Żyrek

2016

Chemistry A European J

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Zinc is one of the most important metal nutrients for species from all kingdoms, being a key structural or catalytic component of hundreds of enzymes, crucial for the survival of both pathogenic microorganisms and their hosts. This work is an overview of the homeostasis of zinc in bacteria and humans. It explains the importance of this metal nutrient for pathogens, describes the roles of zinc sensors, regulators, and transporters, and summarizes various uptake systems and different proteins involved in zinc homeostasis-both those used for storage, buffering, and signaling inside the cell and those excreted in order to obtain Zn from the host. The human zinc-dependent immune system response is explained, with a special focus given to 'zinc nutritional immunity', a process that describes the competition between the bacteria or fungus and the host for this metal, during which both the pathogen and host make huge efforts to control zinc availability. This sophisticated tug of war over Zn might be considered as a possible target for novel antibacterial therapies.

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“…Zn 2+ is the second most abundant transition metal ion which regulates immune function, signal transduction, neurotransmission, regulation of metalloenzymes etc –. Since the disruption of Zn 2+ homeostasis has been associated with several neurological disorders such as inflammation in Alzheimer and Parkinson's diseases and amylotropic lateral sclerosis,– the development of non‐invasive technique for real‐time imaging of endogenous Zn 2+ is very essential.…”

Section: Introductionmentioning

confidence: 99%

pH‐Controlled Nanoparticles Formation and Tracking of Lysosomal Zinc Ions in Cancer Cells by Fluorescent Carbazole–Bipyridine Conjugates

et al. 2018

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Fluorescent probes for simultaneous detection of multiple organelle specific analytes in cancer cells are essential for bioimaging applications. During abnormalities in cells, among other important parameters (metal ions, reactive oxygen species (ROS), enzymes, etc.) pH and Zn2+ are also altered in cells. Herein, we report the formation of nanoparticles of the fluorescent molecules based on carbazole‐bipyridine conjugates (CBL1‐3) and their use as nanoprobes to simultaneously detect Zn2+ and pH variations in lysosome. Upon increasing the pH from 4–6, these probes form nanoparticles with increased size and enhanced fluorescence at 510 nm. Among CBL1‐3, nanoparticles of CBL2 upon Zn2+ binding, exhibit pH responsive intensity change only at lysosomal pH window at 610 nm and become silent above pH 7. Fluorescent imaging experiments on cancer cells revealed that the CBL2 nanoprobe is capable of localizing at lysosomes and facilitates the detection of endogenous Zn2+ and pH variations. Furthermore, the lysosomal Zn2+ variation with external stimuli induced programmed cell death was visualized using the nanoprobe.

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Accessible Archives

Cited by 11 publications

References 0 publications

Dietary Micronutrients Promote Neuronal Differentiation by Modulating the Mitochondrial‐Nuclear Dialogue

Dietary Micronutrients Promote Neuronal Differentiation by Modulating the Mitochondrial‐Nuclear Dialogue

Zinc Homeostasis at the Bacteria/Host Interface—From Coordination Chemistry to Nutritional Immunity

pH‐Controlled Nanoparticles Formation and Tracking of Lysosomal Zinc Ions in Cancer Cells by Fluorescent Carbazole–Bipyridine Conjugates

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