The Covid-19 epidemic has altered the working system of Malaysian Higher Education Institutions. To deal with the pandemic crisis, new regulations were put in place. The academic system must continue so that pupils are not left behind. Open and Distance Learning (ODL), sometimes known as online education or E-Learning, is an important component of the country's educational system. The main objective of this study is to examine the relationship between instructor, accessibility and university support towards the acceptance of e-Learning among students. This study used a quantitative research approach, with data obtained via questionnaires. The population consisted of 117 students enrolled in the Strategic Management courses and the Statistical Package for the Social Sciences (SPSS) was used to answer the objective of this study. The finding shows that, all the independent variables which is instructor, accessibility and university support had a positive significant relationship toward dependent variable e-learning acceptance. E-learning success is important for a variety of reasons, including its potential to expand access to education, increase learner engagement and motivation, and improve learning outcomes. From this finding, it help the university to strategize and make plans in enhancing the implementation of e-learning for their students. A part of limitation, future research should broaden the scope of this study to include additional UiTM branches, public universities, or private universities.