Accessing random diffusivity in a hydrogel-based brain’s paranchyma phantom

Lavrova, Anastasia I.; Sychev, Alexander V.; Vanina, Anastasia S.; Grekhnyova, Elena V.; Postnikov, Eugene B.

doi:10.1109/iciibms55689.2022.9971620

Cited by 1 publication

(4 citation statements)

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“…The typical sequence of processes consists of a fast spread of the contrast liquid in a thin layer around the channel formed by the needle at the injection, which is followed by a more slow process. This corresponds to the picture observed earlier during the photometric video registration of the fluorescent marker spread in one such hydrogel [38]. However, this first stage is too fast to be registered by computed tomography.…”

Section: Modelingsupporting

confidence: 84%

“…This takes a few seconds, but a single run of CT scanning requires at least tens of seconds. In addition, as has been demonstrated in the work [38], the beginning of the subsequent diffusive-type process, which can have a Brownian yet non-Gaussian character [6,39], also takes a limited time interval, after which the homogenization occurs. The latter implies that the region covered by the spreading agent significantly overcomes the characteristic sizes of the medium's local inhomogeneities.…”

Section: Modelingmentioning

confidence: 71%

“…Two series of measurements, formed from CT slices which were able to produce a 3D picture, were carried out. The first one operated with the CT-assisted determination of Iopromide's spread in the hydrogel phantom without special additives (the same kind of medium which was considered in the works [27,38] with respect to the 2D projection of a fluorescence marker spread). The second series addressed hydrogel samples with additives.…”

Section: Computed Tomography Resultsmentioning

confidence: 99%

“…The latter, used in this work, differs from the case considered in the work [28], where macroscopic non-uniform inclusions of lipid components were considered to affect non-classic features of a fluorescent marker's spread. CT deals with a coarse spatiotemporal resolution, i.e., it is not suitable for investigation of individual tracers in gels as e.g., in the work [31], or a short-time behavior, as in [38]. As such, the main focus of the present work is on the homogenized diffusive properties of the medium with respect to the spread of a liquid contrast medium.…”

Section: Discussionmentioning

confidence: 99%

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Computed Tomography-Assisted Study of the Liquid Contrast Agent’s Spread in a Hydrogel Phantom of the Brain Tissue

Vanina

Sychev

Lavrova

et al. 2023

Fluids

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Studying transport processes in the brain’s extracellular space is a complicated problem when considering the brain’s tissue. Tests of corresponding physical and mathematical problems, as well as the need for materials with cheap but realistic properties to allow for testing of drug delivery systems, lead to the development of artificial phantom media, one kind of which is explored in this work. We report results from quantifying the spread of a standard contrast agent used in clinical computed tomography, Iopromide, in samples of collagen-based hydrogels. Its pure variant as well as samples supplied with lipid and surfactant additives were explored. By comparing to solutions of the diffusion equation which reproduce these data, the respective diffusion coefficients were determined. It was shown that they are relevant to the range typical for living tissue, grow with elevation in the lipid content and diminish with growth in surfactant concentration.

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Section: Modelingsupporting

confidence: 84%