Accident vasculaire cérébral ischémique révélant une maladie coeliaque

Belfkih, Rachid; Souirti, Zouhayr; Chtaou, Naïma; Messouak, O.; Belahsen, Faouzi

doi:10.4314/pamj.v5i1.56196

Cited by 6 publications

(9 citation statements)

References 8 publications

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“…CD should be considered as a possible etiology for stroke cases of unknown cause, particularly in youth, whether gastrointestinal manifestations are evident or not[ 67 ]. The pathogenesis of stroke in CD youth may involve vitamin B12 deficiency[ 68 ] and possibly hyperhomocysteinemia, which may be secondary to folic acid deficiency[ 69 ], cerebral arterial vasculopathy, and antiphospholipid syndrome, a secondary autoimmune disorder[ 70 - 72 ]. Children with recurrent acute ischemic stroke should be screened for CD[ 73 ].…”

Section: Publication Summary Statisticsmentioning

confidence: 99%

Cardiovascular involvement in celiac disease

et al. 2017

WJC

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Celiac disease (CD) is an autoimmune response to ingestion of gluten protein, which is found in wheat, rye, and barley grains, and results in both small intestinal manifestations, including villous atrophy, as well as systemic manifestations. The main treatment for the disease is a gluten-free diet (GFD), which typically results in the restoration of the small intestinal villi, and restoration of other affected organ systems, to their normal functioning. In an increasing number of recently published studies, there has been great interest in the occurrence of alterations in the cardiovascular system in untreated CD. Herein, published studies in which CD and cardiovascular terms appear in the title of the study were reviewed. The publications were categorized into one of several types: (1) articles (including cohort and case-control studies); (2) reviews and meta-analyses; (3) case studies (one to three patient reports); (4) letters; (5) editorials; and (6) abstracts (used when no full-length work had been published). The studies were subdivided as either heart or vascular studies, and were further characterized by the particular condition that was evident in conjunction with CD. Publication information was determined using the Google Scholar search tool. For each publication, its type and year of publication were tabulated. Salient information from each article was then compiled. It was determined that there has been a sharp increase in the number of CD - cardiovascular studies since 2000. Most of the publications are either of the type “article” or “case study”. The largest number of documents published concerned CD in conjunction with cardiomyopathy (33 studies), and there have also been substantial numbers of studies published on CD and thrombosis (27), cardiovascular risk (17), atherosclerosis (13), stroke (12), arterial function (11), and ischemic heart disease (11). Based on the published research, it can be concluded that many types of cardiovascular issues can occur in untreated CD patients, but that most tend to resolve on a GFD, often in conjunction with the healing of small intestinal villous atrophy. However, in some cases the alterations are irreversible, underscoring the need for CD screening and treatment when cardiovascular issues arise of unknown etiology.

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Section: Publication Summary Statisticsmentioning

confidence: 99%

Cardiovascular involvement in celiac disease

et al. 2017

WJC

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“…There are eleven published cases of such association in the literature. In three cases [11][12][13], hyperhomocysteinemia prompted an ischemic stroke before a diagnosis of CD was made, whereas in one case, hyperhomocysteinemia provoked cerebral venous thrombosis in a patient with untreated CD [14].…”

Section: Discussionmentioning

confidence: 99%

Concurrent cerebral arterial and venous sinus thrombosis revealing celiac disease - A case report and literature review

Alhosain

Kouba

2020

Preprint

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Background: Celiac disease is an autoimmune condition characterized by an inappropriate immune reaction against gluten. It classically presents as chronic diarrhea, bloating, and nausea in addition to malabsorption symptoms such as weight loss and micronutrient deficiency. We report the first case of coinciding cerebral infarction and venous sinus thrombosis unveiling the diagnosis of celiac disease.Case Presentation: A 40-year old female patient with a four-day history of severe diarrhea presented with right hemiplegia and altered mental status. Imaging revealed left middle cerebral artery occlusion and left transverse and sigmoid venous sinus thrombosis, along with left jugular vein thrombosis. Her laboratory evaluation was notable for profound iron deficiency anemia, thrombocytosis, and hyperhomocysteinemia. Her positive anti-tissue transglutaminase IgA antibodies and ensuing duodenal biopsy confirmed the diagnosis of celiac disease.Conclusions: Celiac disease has a wide range of intestinal and extra-intestinal manifestations and can present with thrombotic events in young patients with iron deficiency and hyperhomocysteinemia.

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“…A brief description of published cases reporting such association in the literature is summarized in Table 1 [2,8,[10][11][12][13][14][15][16][17][18].…”

Section: Malabsorption-induced Vitamin Deficiencymentioning

confidence: 99%

Concurrent cerebral arterial and venous sinus thrombosis revealing celiac disease- a case report and literature review

Alhosain

Kouba

2020

BMC Gastroenterol

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Background Celiac disease is an autoimmune condition characterized by an inappropriate immune reaction against gluten. It classically presents as chronic diarrhea, bloating, and nausea in addition to malabsorption symptoms such as weight loss and micronutrient deficiency. We report the first case of coinciding cerebral infarction and venous sinus thrombosis unveiling the diagnosis of celiac disease. Case presentation A 40-year old female patient with a four-day history of severe diarrhea presented with right hemiplegia and altered mental status. Imaging revealed left middle cerebral artery occlusion and left transverse and sigmoid venous sinus thrombosis, along with left jugular vein thrombosis. Her laboratory evaluation was notable for profound iron deficiency anemia, thrombocytosis, and hyperhomocysteinemia. Her positive anti-tissue transglutaminase IgA antibodies and ensuing duodenal biopsy confirmed the diagnosis of celiac disease. Conclusions Celiac disease has a wide range of intestinal and extraintestinal manifestations and can present with thrombotic events in young patients with iron deficiency and hyperhomocysteinemia.

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Accident vasculaire cérébral ischémique révélant une maladie coeliaque

Cited by 6 publications

References 8 publications

Cardiovascular involvement in celiac disease

Cardiovascular involvement in celiac disease

Concurrent cerebral arterial and venous sinus thrombosis revealing celiac disease - A case report and literature review

Concurrent cerebral arterial and venous sinus thrombosis revealing celiac disease- a case report and literature review

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