Accidental Poisoning by Death Cap Mushrooms: Be Careful What You Eat

Lawton, Luke; Bhraonáin, Sinéad Ní

doi:10.1016/j.wem.2012.11.001

Cited by 9 publications

(5 citation statements)

References 5 publications

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“…2 Poisoning caused by the "death cap" mushroom Amanita phalloides has often been reported. 3 It is one of the most toxic wild mushrooms in the world and can cause acute liver failure and death in humans. 4,5 Cortinarius species have also been reported to cause renal failure.…”

Section: Introductionmentioning

confidence: 99%

Russula subnigricans Poisoning: From Gastrointestinal Symptoms to Rhabdomyolysis

Lin

Yang

et al. 2015

Wilderness & Environmental Medicine

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Wild mushroom poisoning is often reported to cause acute liver or renal failure. However, acute rhabdomyolysis caused by wild mushroom poisoning has rarely been reported. We describe 7 patients of 1 family with Russula subnigricans Hongo poisoning. Their clinical manifestations varied from gastrointestinal symptoms to rhabdomyolysis, with 1 fatality. Our report provides supporting evidence that rhabdomyolysis may result from ingestion of R subnigricans mushrooms. A key to survival for patients with rhabdomyolysis caused by R subnigricans poisoning may be early recognition and intensive supportive care.

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Section: Introductionmentioning

confidence: 99%

Russula subnigricans Poisoning: From Gastrointestinal Symptoms to Rhabdomyolysis

Lin

Yang

et al. 2015

Wilderness & Environmental Medicine

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“…3 -5 Since the 1990s, several toxic mushroom species have been reported, and new mushroom syndromes have been recently described. 3,6,7…”

Section: Introductionmentioning

confidence: 99%

“…[3][4][5] Since the 1990s, several toxic mushroom species have been reported, and new mushroom syndromes have been recently described. 3,6,7 Among these syndromes, Russula subnigricans poisoning can be classified as a delayed-onset rhabdomyolytic syndrome. R subnigricans is mainly found in East Asia and was first found in Japan in 1955.…”

Section: Introductionmentioning

confidence: 99%

Mortality Cases of Mushroom Poisoning with Russula subnigricans

Chun

Min

Ryu

et al. 2023

Wilderness & Environmental Medicine

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Mushroom poisoning is increasing worldwide, as well as the incidence of fatal mushroom poisoning. Several new syndromes associated with mushroom poisoning have been described in the literature. Notably, 1 of the newly identified mushroom poisonings is Russula subnigricans poisoning. R subnigricans can be classified as causing a delayed-onset rhabdomyolytic syndrome as patients with this severe poisoning present with severe rhabdomyolysis, acute kidney injury, and cardiomyopathy. However, there are only a few reports on the toxicity of R subnigricans. We recently treated 6 patients with R subnigricans mushroom poisoning, of whom 2 died. The 2 patients showed severe rhabdomyolysis, metabolic acidosis, acute renal failure, electrolyte imbalance, and irreversible shock, which caused their deaths. Mushroom poisoning should be considered in the evaluation of rhabdomyolysis of unknown origin. In addition, in cases of mushroom poisoning with severe rhabdomyolysis, R subnigricans poisoning should be promptly identified.

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“…The underlying toxicological mechanisms are usually associated with RNA polymerase II inhibition, which may induce changes in normal cell metabolism, cell death, and tissue necrosis (19). Identifying an antidote remains a challenging task, and innovative therapies are critically needed for the treatment of patients (20)(21)(22).…”

Section: Introductionmentioning

confidence: 99%

Identification and quantification of α- and β-amanitin in wild mushrooms by HPLC-UV-EC and HPLC-DAD-MS detection

Barbosa¹,

Domingues

Ramos

et al. 2022

Preprint

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Amatoxins are a group of highly toxic peptides, which include α- and β-amanitin, found in several species of mushrooms (e.g. Amanita phalloides). Due to their high hepatotoxicity, they account for most deaths occurring after mushrooms ingestion. The determination of α- and β-amanitin content in wild mushrooms is invaluable for treating cases involving poisoning. In the present study, we have developed and validated an analytical method based on high-performance liquid chromatography, with in-line ultraviolet and electrochemical detection (HPLC-UV-EC), for the rapid quantification of α- and β-amanitin in wild mushroom samples collected from the Inner Center of Portugal. A reproducible and simple solid-phase extraction (SPE) using OASIS®PRIME HLB cartridges was used for sample pre-treatment, followed by chromatographic separation based on the RP-C18 column. The UV and EC chromatograms of α- and β-amanitin were recorded at 305 nm and +0.600 V vs Ag/AgCl, respectively. The linear quantification for both amanitins was in the range of 0.5–20.0 μg mL−1 (R2 > 0.999). The LOD, calculated based on the calibration curve, was similar for UV and EC detection (0.12-0.33 μg mL−1). Intra-day and inter-day precision were less than 13%, and the recovery ratios ranged from 89% to 117%. Nine Amanita species and five edible mushrooms were analysed by HPLC-UV-EC, and HPLC-DAD-MS confirmed the identification of amatoxins. We find high α- and β-amanitin content in A. phalloides and not in the other species analysed. In sum, the developed and validated method provides a simple and fast analysis of α- and β-amanitins contents in wild mushrooms and is suitable for screening and routine assessment of mushroom intoxication.

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Accidental Poisoning by Death Cap Mushrooms: Be Careful What You Eat

Cited by 9 publications

References 5 publications

Russula subnigricans Poisoning: From Gastrointestinal Symptoms to Rhabdomyolysis

Russula subnigricans Poisoning: From Gastrointestinal Symptoms to Rhabdomyolysis

Mortality Cases of Mushroom Poisoning with Russula subnigricans

Identification and quantification of α- and β-amanitin in wild mushrooms by HPLC-UV-EC and HPLC-DAD-MS detection

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