In this paper a Fault-Tolerant Control strategy against sensors failures for Hypersonic flight has been proposed. The novel approach is based on the robustness capabilities of Direct Model Following (DAMF) method and at the same time it uses sensors accuracy information to improve the adaptivity to sensors failures. DAMF is a Model Reference Control Strategy that asymptotically guarantees a null error between the output of the reference model and the one of the real plant, through a direct adaptation of control loop gains. The proposed algorithm modifies the Direct Adaptive Model Following method by adding a module, that varies the controller parameters having a direct influence on the updating rules of controller gains (i.e. on the adaptive capability of the controller) to obtain Fault Tolerance capabilities. A numerical analysis, carried out by using the flight dynamics model of FTB X vehicle, a flying test bed designed in the framework of Unmanned Space Vehicle programme of Italian Aerospace Research Centre, has demonstrated that the proposed fault-tolerant algorithm has good tracking performances and global closed loop stability in case of both single and multiple failures. Nomenclature x = plant system state vector y = plant system output vector y m = reference system output vector A m = reference system parameters B m = reference system parameters r = reference system input vector u = control law G 0 = adaptation gain matrix C 0 = adaptation gain matrix ν = adaptation gain matrix K 0 = feed-forward gain matrix P = matrix solution of the Lyapunov equation Q = positive definite weighting matrix A e = error matrix γ 1 = adaptation speed parameter γ 2 = adaptation speed parameter γ 3 = adaptation speed parameter R = matrix of the states feedback variables uncertainties R 0 = nominal value matrix of the states feedback variables uncertainties k = a scale factor α = angle of attack q = pitch rate σ = standard deviation of the sensor noise