Accommodation Related to the Action of Ethanol on Frog Sciatic Nerve

Quevedo, L; Baldeig, J; Concha, J; Benoit, Isabelle

doi:10.1159/000136863

Cited by 5 publications

(5 citation statements)

References 8 publications

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“…Guttman (4), Quevedo et ai (6,8) and Vivaldi et al (10) pointed to nerve accommoda tion as the most sensitive electrophysiological parameter and suggested that this excitability index should be preferentially used. The basic fact in nerve accommodation is that any slowly rising current increases the threshold to the applied stimulus.…”

Section: Introductionmentioning

confidence: 99%

Nerve Accommodation in Chronic Alcoholic Subjects

Quevedo¹,

Concha²,

Marchant³

et al. 1980

Pharmacology

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Chronaxie, rheobase, conduction velocity and nerve accommodation of 50 alcoholic subjects were studied by applying rectangular and exponentially rising currents to the median nerve. A statistically significant decrease in nerve accommodation indexes and a change in the slope of the accommodation curve were found. The results show that nerve accommodation is more sensitive than other excitability parameters and should be used in the diagnosis and prognosis of alcoholic neuropathies.

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Section: Introductionmentioning

confidence: 99%

Nerve Accommodation in Chronic Alcoholic Subjects

Quevedo¹,

Concha²,

Marchant³

et al. 1980

Pharmacology

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“…The accommodation curves measured in the brachioradialis muscle, when the ERC had a time constant greater than 40 ms, showed a breakdown similar to that in nerves [14,16,17]. The breakdown in the accommodation curves of nerves has been considered to be due to the successive stimulation of different groups of fibers, with heterogeneous properties of excitability and accommodation [19,22].…”

Section: Discussionmentioning

confidence: 99%

“…Even though accommodation has been described as the most sensitive parameter of excitability in the conducting membrane [5,16] there is a total lack of documentation concerning the changes of this excitability parameter during hypoxic conditions. The study of the behavior of the muscle accommodation and the changes in the kalemia and resting membrane potential (RMP) in rats under hypoxic conditions induced by tourniquet, with high and low mortality, are the objects of this work.…”

Section: Introductionmentioning

confidence: 99%

Accommodation of skeletal muscle in rats under hypoxic conditions induced by tourniquet

1983

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Resting membrane potential (RMP) and indexes of accommodation (IA) were obtained from the brachioradialis muscle in rats subjected to 2 or 5 h of bilateral hindlimb tourniquet. The results showed a highly significant increase in muscular IA with a return to the control values for the rats with 2 h of tourniquet, while the increased in the IA is maintained all the survival period in the rats with 5 h of tourniquet. The velocity of increasing of the IA bears a direct relationship to the outcome of the injury. A decrease in the RMP of the brachioradialis muscle and an increase in the extracellular K+ and H+ was also observed. The early differences in the behavior of the accommodation parameter allowed a clear differentiation of the rats which survived the tourniquet shock from those who finally died.

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“…Higher concentrations (>100 mM) cause a further depolarization, decreased sodium conductance, and the inactivation of sodium channels, resulting in a slower propagation velocity and a lower action potential amplitude (Seeman, 1972). Small unmyelinated fibres are affected more than larger myelinated fibres (Quevedo et al, 1978) .…”

Section: Electrophysiological Studies Indicate Golgi Cellsmentioning

confidence: 96%

Ethanol effects on the olivocerebellar system

Sinclair¹,

Lo²,

Harris³

1982

Can. J. Physiol. Pharmacol.

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Ethanol (1.5 g/kg i.v.) was found to decrease spontaneous complex spike (CS) activity in cerebellar Purkinje cells in urethane anaesthetized rats while not changing the threshold required to evoke a CS by juxtafastigial stimulation. Thus ethanol does not decrease CS activity by an action at the climbing fibre-Purkinje cell synapse. Tremor induced by harmaline (5 mg/kg i.v.) in unanaesthetized animals was markedly antagonized by ethanol (0.5-2.0 g/kg i.v.) in all animals tested. However, in nine urethane-anaesthetized animals, ethanol markedly reversed the effects of harmaline on Purkinje cells in only two cases and partially reversed the effects in another four cells. Thus, the depressant effects of ethanol on the inferior olive is not total responsible for the blockade of the harmaline tremor bur would account for the decrease in spontaneous CS activity.

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Accommodation Related to the Action of Ethanol on Frog Sciatic Nerve

Cited by 5 publications

References 8 publications

Nerve Accommodation in Chronic Alcoholic Subjects

Nerve Accommodation in Chronic Alcoholic Subjects

Accommodation of skeletal muscle in rats under hypoxic conditions induced by tourniquet

Ethanol effects on the olivocerebellar system

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