Accompanying photocytotoxic activity of gold nanoechinus and zinc phthalocyanine on cancerous cell lines

Sobhani, Nafiseh; Dolat, Elham; Darroudi, Majid; Hashemzadeh, Alireza; Khoobi, Mehdi; Salarabadi, Samaneh Soudmand; Hoseini, Benyamin; Sazgarnia, Ameneh

doi:10.1016/j.pdpdt.2020.101929

Cited by 7 publications

(3 citation statements)

References 31 publications

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“…The detected absorption peak at 521 cm −1 in both samples confirmed the formation of zinc oxide. [ 47,86 ] However, the observed absorption peak at 1618 cm −1 in the piece of ZnO‐Gd‐OXA NPs @ polymer shell was allocated to the symmetrical vibration of the carbonyl group of the oxalic acid ligand. The recorded absorption at 681 cm −1 was also attributed to the Pt–N bond vibration (Figure 7).…”

Section: Resultsmentioning

confidence: 99%

The advance anticancer role of polymeric core‐shell ZnO nanoparticles containing oxaliplatin in colorectal cancer

Alavi

Maghami

Pakdel

et al. 2023

J Biochem & Molecular Tox

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We evaluated the activity of core‐shell ZnO nanoparticles (ZnO‐NPs@polymer shell) containing Oxaliplatin via polymerization through in vitro studies and in vivo mouse models of colorectal cancer. ZnO NPs were synthesized in situ when the polymerization step was completed by co‐precipitation. Gadolinium coordinated‐ZnONPs@polymer shell (ZnO‐Gd NPs@polymer shell) was synthesized by exploiting Gd's oxophilicity (III). The biophysical properties of the NPs were studied using powder X‐ray diffraction (PXRD), Fourier transforms infrared spectroscopy, Ultraviolet‐visible spectroscopy (UV‐Vis), field emission electron microscopy (FESEM), transmission electron microscopy (TEM), atomic force microscopy, dynamic light scattering, and z‐potential. (3‐(4,5‐Dimethylthiazol‐2‐yl)−2,5‐diphenyltetrazolium bromide) (MTT) was used to determine the antiproliferative activity of ZnO‐Gd‐OXA. Moreover, a xenograft mouse model of colon cancer was exerted to survey its antitumor activity and effect on tumor growth. In the following, the model was also evaluated by histological staining (H‐E; Hematoxylin & Eosin and trichrome staining) and gene expression analyses through the application of RT‐PCR/ELISA, which included biochemical evaluation (MDA, thiols, SOD, CAT). The formation of ZnO NPs, which contained a crystallite size of 16.8 nm, was confirmed by the outcomes of the PXRD analysis. The Plate‐like morphology and presence of Pt were obtained in EDX outcomes. TEM analysis displayed the attained ZnO NPs in a spherical shape and a diameter of 33 ± 8.5 nm, while the hydrodynamic sizes indicated that the particles were highly aggregated. The biological results demonstrated that ZnO‐Gd‐OXA inhibited tumor growth by inducing reactive oxygen species and inhibiting fibrosis, warranting further research on this novel colorectal cancer treatment agent.

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Section: Resultsmentioning

confidence: 99%

The advance anticancer role of polymeric core‐shell ZnO nanoparticles containing oxaliplatin in colorectal cancer

Alavi

Maghami

Pakdel

et al. 2023

J Biochem & Molecular Tox

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“…Among them, metallic gold nanostructures have been noted for their non-toxic and desirable optic nature (tunable localized surface plasmon resonances (LSPR)). To this end among the several gold nanoparticle morphologies, Au nano-echinus structures with high extinction coefficient of ∼10 12 M − 1 cm − 1 in the NIR region seem to exhibit excellent PDT efficiency in both biological windows I and II [104,114].…”

Section: Nir Photosensitizersmentioning

confidence: 99%

“…PDT is generally fitted to superficial lesions; then, it is less efficient in the treatment of large and metastatic tumors. Anyway, with the help of reasonable highpower LEDs and upon excitation by the light source with long wavelength (NIR), the penetration depth increases [104].…”

Section: Advantages Of Photodynamic Therapymentioning

confidence: 99%

Implications of photodynamic cancer therapy: an overview of PDT mechanisms basically and practically

Sobhani

Samadani

2021

J Egypt Natl Canc Inst

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Background Tumor eradication is one of the most important challengeable categories in oncological studies. In this account, besides the molecular genetics methods including cell therapy, gene therapy, immunotherapy, and general cancer therapy procedures like surgery, radiotherapy, and chemotherapy, photodynamic adjuvant therapy is of great importance. Photodynamic therapy (PDT) as a relatively noninvasive therapeutic method utilizes the irradiation of an appropriate wavelength which is absorbed by a photosensitizing agent in the presence of oxygen. Main body of the abstract In this procedure, a series of events lead to the direct death of malignant cells such as damage to the microvasculature and also the induction of a local inflammatory function. PDT has participated with other treatment modalities especially in the early stage of malignant tumors and has resulted in decreasing morbidity besides improving survival rate and quality of life. High spatial resolution of PDT has attracted considerable attention in the field of image-guided photodynamic therapy combined with chemotherapy of multidrug resistance cancers. Although PDT outcomes vary across the different tumor types, minimal natural tissue toxicity, minor systemic effects, significant reduction in long-term disease, lack of innate or acquired resistance mechanisms, and excellent cosmetic effects, as well as limb function, make it a valuable treatment option for combination therapies. Short conclusion In this review article, we tried to discuss the potential of PDT in the treatment of some dermatologic and solid tumors, particularly all its important mechanisms.

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Recent advancement in photosensitizers for photodynamic therapy

Singh,

Sinha,

Gahtori

et al. 2024

Dyes and Pigments

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Accompanying photocytotoxic activity of gold nanoechinus and zinc phthalocyanine on cancerous cell lines

Cited by 7 publications

References 31 publications

The advance anticancer role of polymeric core‐shell ZnO nanoparticles containing oxaliplatin in colorectal cancer

The advance anticancer role of polymeric core‐shell ZnO nanoparticles containing oxaliplatin in colorectal cancer

Implications of photodynamic cancer therapy: an overview of PDT mechanisms basically and practically

Recent advancement in photosensitizers for photodynamic therapy

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