Accroissement par <i>Staphylococcus aureus</i> de la résistance de la souris envers l'infection par <i>Pseudomonas aeruginosa</i>

Derepentigny, J; Mathieu, L. G.; Coallier-Ascah, J

doi:10.1139/m76-149

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Nous avons dtja observC que l'injection de souches de S. aureus coagulase-positives prtvient la mort des souris injecttes avec une dose lttale de P. aerilginosa en favorisant la diminution en nombre des cellules de cette dernitre esptce dans la cavitt ptritontale (6). Au cours de la m&me t t l d e nous avions extcuti quelques recherches prtliminaires sur certains aspects de cette rtsistance accrue.…”

Section: Discussionunclassified

See 1 more Smart Citation

Caractéristiques de l'accroissement de la résistance de la souris contre Pseudomonas aeruginosa provoqué par Staphylococcus aureus

Mathieu¹,

deRepentigny²,

Gadbois³

1976

Can. J. Microbiol.

Self Cite

View full text Add to dashboard Cite

Mice were protected against a lethal dose of Pseudomonas aeruginosa by a previous sublethal infection with Staphylococcus aureus. Under similar conditions, Staphylococcus epidermidis afforded only slight protection. The following characteristics of this increased resistance that we have observed are (1) survival of mice, and decrease of the number of viable units of P. aeruginosa in the peritoneal cavity of the same mice infected with S. aureus coagulase-positive strains, either from our laboratory collection or from hospital cases, when the time interval between the injection with staphylococci and that of P. aeruginosa was between 4 and 96 h; (2) absence of a net inhibitory effect in vitro on P. aeruginosa with serum from mice infected with a sublethal dose of coagulase-positive S. aureus; (3) changes in the appearance of peritoneal exudate cells after infection with a sublethal dose of S. aureus; P. aeruginosa injected afterwards in the peritoneal cavity of mice was eliminated; when P. aeruginosa was injected alone, "activated macrophages" were not observed and bacterial cells were present in large numbers in the exudate. The immunostimulation induced by a previous sublethal injection of S. aureus coagulase-positive strains seemed to be inhibited by the immunosuppressive drug cyclophosphamide, since mice were no longer protected against a lethal dose of P. aeruginosa. Cell immunity may intervene in such infections with opportunistic species and check the invasiveness of a gram-negative bacterium superinfecting a host already exposed to coagulase-positive S. aureus.

show abstract

Section: Discussionunclassified

“…La survie de la souris et celle des microorganismes dans la cavitk peritoneale de la souris ont ete Cvalutes selon des methodes publiies anterieurement (6,14,16). Des souris males CFI de 18 a 20 g ont servi a nos experiences.…”

Section: Eualimtiotr De La Rdsistnnce Rlr I'l~bfeunclassified

Caractéristiques de l'accroissement de la résistance de la souris contre Pseudomonas aeruginosa provoqué par Staphylococcus aureus

Mathieu¹,

deRepentigny²,

Gadbois³

1976

Can. J. Microbiol.

Self Cite

View full text Add to dashboard Cite

show abstract

Inhibition of Pseudomonas aeruginosa slime production by staphylococcal extracellular product

Shibl¹,

Al-Sowaygh²

1980

J Clin Microbiol

View full text Add to dashboard Cite

Staphylococcus aureus produced an inhibitory factor that suppressed slime formation by Psuudomonas aeruginosa but had little effect on the growth of the organism. The inhibitory factor was not found in broth cultures but could be extracted from cultures grown on solid agar. The inhibitory factor moderately inhibited gram-negative bacteria in addition to inhibiting a variety of gram-positive bacteria. The inhibitory factor was found to have a low molecular weight, as judged by its diffusibility, and it could be partially purified by gel filtration on Sephadex G-50. It was observed to be heat labile; however, its activity was stable within a wide pH range. The factor was resistant to deoxyribonuclease, ribonuclease, and lipase, but sensitive to trypsin. The role of the inhibition of slime production in pathogenicity is discussed.

show abstract

Accroissement par Staphylococcus aureus de la résistance de la souris envers l'infection par Pseudomonas aeruginosa

Cited by 2 publications

References 0 publications

Caractéristiques de l'accroissement de la résistance de la souris contre Pseudomonas aeruginosa provoqué par Staphylococcus aureus

Caractéristiques de l'accroissement de la résistance de la souris contre Pseudomonas aeruginosa provoqué par Staphylococcus aureus

Inhibition of Pseudomonas aeruginosa slime production by staphylococcal extracellular product

Contact Info

Product

Resources

About