Acculturation and Nonalcoholic Fatty Liver Disease Risk Among Hispanics of Mexican Origin: Findings From the National Health and Nutrition Examination Survey

Balakrishnan, Maya; Kanwal, Fasiha; El–Serag, Hashem B.; Thrift, Aaron P.

doi:10.1016/j.cgh.2016.09.149

Cited by 15 publications

(15 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, they had lower levels of serum adiponectin and high-density lipoprotein than females [ 204 ]. The higher prevalence in women in this study is in contrast to other reports that have found a higher prevalence of NAFLD in men [ 20 , 78 ].…”

Section: Demographic Factorscontrasting

confidence: 99%

“…Epidemiological studies describe inter-individual differences in the NAFLD prevalence depending on the ethnicity. Hispanic Americans have the highest prevalence of NAFLD, followed by Americans of European descent, and African Americans having the lowest prevalence [ 76 , 77 , 78 ]. In this regard, African Americans show a different metabolic response to obesity and IR, as defined by reduced hypertriglyceridemia, steatosis, and accumulation of triglycerides in the visceral adipose tissue compared to Hispanics [ 79 , 80 ].…”

Section: Genetic Factorsmentioning

confidence: 99%

See 1 more Smart Citation

Non-Alcoholic Fatty Liver Disease: Metabolic, Genetic, Epigenetic and Environmental Risk Factors

Juanola

Martínez-López

Francés

et al. 2021

IJERPH

163

View full text Add to dashboard Cite

Non-alcoholic fatty liver disease (NAFLD) is one of the most frequent causes of chronic liver disease in the Western world, probably due to the growing prevalence of obesity, metabolic diseases, and exposure to some environmental agents. In certain patients, simple hepatic steatosis can progress to non-alcoholic steatohepatitis (NASH), which can sometimes lead to liver cirrhosis and its complications including hepatocellular carcinoma. Understanding the mechanisms that cause the progression of NAFLD to NASH is crucial to be able to control the advancement of the disease. The main hypothesis considers that it is due to multiple factors that act together on genetically predisposed subjects to suffer from NAFLD including insulin resistance, nutritional factors, gut microbiota, and genetic and epigenetic factors. In this article, we will discuss the epidemiology of NAFLD, and we overview several topics that influence the development of the disease from simple steatosis to liver cirrhosis and its possible complications.

show abstract

Section: Demographic Factorscontrasting

confidence: 99%

Section: Genetic Factorsmentioning

confidence: 99%

Non-Alcoholic Fatty Liver Disease: Metabolic, Genetic, Epigenetic and Environmental Risk Factors

Juanola

Martínez-López

Francés

et al. 2021

IJERPH

163

View full text Add to dashboard Cite

show abstract

“…As such, the high prevalence of NAFLD amongst Mexican Americans and other Hispanics observed in our study may be due to other genetic factors, as genetic susceptibility for NAFLD is significantly higher in those of Mexican and Hispanic descent . Adoption of American culture and lifestyle amongst Hispanics has not been found to be a risk factor for NAFLD, though this effect should be further studied as more data on other ethnic groups is released in NHANES .…”

Section: Discussionmentioning

confidence: 57%

Ethnic influence on nonalcoholic fatty liver disease prevalence and lack of disease awareness in the United States, 2011–2016

Yeo

Cheung

et al. 2020

J Intern Med

View full text Add to dashboard Cite

Background Nonalcoholic fatty liver disease (NAFLD) is a rising global disease associated with clinical and economic burdens. Objectives We aimed to quantify NAFLD prevalence and awareness to provide stakeholders necessary information to combat NAFLD burden. Methods This study utilizes data from the National Health and Nutrition Examination Survey 2011–2016 and included 4538 adult participants who did not have heavy drinking or viral hepatitis history. The US fatty liver index defined NAFLD and NAFLD fibrosis score defined fibrosis. NAFLD awareness was captured by questionnaire. Results Amongst the study population of 4538 persons, NAFLD prevalence was 32.5%, lowest in non‐Hispanic Blacks (18.0%) and Asians (18.1%), highest amongst Mexican Americans (48.4%). Within the NAFLD group, advanced fibrosis was highest in non‐Hispanic Blacks (28.5%) and lowest amongst non‐Hispanic Asians (2.7%). Of the 1473 (97.5%) NAFLD participants who answered NAFLD awareness question, 90% visited a healthcare centre at least once in the past year, but only 5.1% were aware of having NAFLD. On weighted population estimates, 77.33 million persons had NAFLD, 17.63 million had advanced fibrosis, and 73.39 million NAFLD participants were not aware of having NAFLD. Conclusions Of 77.33 million people in the United States have NAFLD with 17.63 million having advanced fibrosis, with lowest prevalence in non‐Hispanic Asians and highest in Mexican Americans. A conundrum exists amongst non‐Hispanic Blacks who have low NAFLD prevalence but highest prevalence of advanced fibrosis. Awareness of NAFLD was low across all ethnicities. Effort is needed to improve disease awareness whilst addressing NAFLD clinical burden across ethnicities.

show abstract

“…Racial differences in prevalence of NAFLD have been most evident in the studies from USA that involved multiethnic populations. Hispanic Americans have the highest prevalence of NAFLD followed by Americans of European descent and African Americans having the lowest prevalence (80)(81)(82). Ethnic differences are also noted within South America, with Brazil reporting the highest NAFLD prevalence and Peru the lowest The lower prevalence of NAFLD among African Americans than Hispanics despite higher prevalence of obesity amongst Non-Hispanics brings into focus the complexities in pathogenesis of NAFLD implicating the role of genetics as well as epigenetic influences operating through diet, lifestyle and other environmental factors.…”

Section: Racementioning

confidence: 99%

Epidemiology of non-alcoholic and alcoholic fatty liver diseases

Mitra¹,

De²,

Chowdhury³

2020

Transl Gastroenterol Hepatol

383

263

View full text Add to dashboard Cite

Accumulation of excessive fat in the liver is the common denominator underlying the two most common and emerging causes of chronic liver disease, alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD), that are emerging public health issues globally. The burden of both ALD and NAFLD are increasing worldwide (1,2). ALD occur as a component of a broader perspective of alcohol abuse disorders, is frequently associated with psychiatric comorbidities and is the most frequent cause of morbidity, health care utilization and mortality in alcohol use disorders (3)(4)(5)(6). This is in contrast to NAFLD that occurs as an essential component of metabolic disorders that are associated with insulin resistance as the pathophysiological hallmark and is clinically manifest as hepatic, pancreatic, cardiac endothelial cell dysfunction and disease. In NAFLD, death is most commonly due to cardiovascular disease and often nonhepatic cancers apart from liver disease (7,8). The current global march of NAFLD as a public health challenge parallels the global upsurge for food intake, increase in per capita income, sedentary lifestyle, increasing body mass index and finally is an expression of an excess of caloric

show abstract

Acculturation and Nonalcoholic Fatty Liver Disease Risk Among Hispanics of Mexican Origin: Findings From the National Health and Nutrition Examination Survey

Cited by 15 publications

References 6 publications

Non-Alcoholic Fatty Liver Disease: Metabolic, Genetic, Epigenetic and Environmental Risk Factors

Non-Alcoholic Fatty Liver Disease: Metabolic, Genetic, Epigenetic and Environmental Risk Factors

Ethnic influence on nonalcoholic fatty liver disease prevalence and lack of disease awareness in the United States, 2011–2016

Epidemiology of non-alcoholic and alcoholic fatty liver diseases

Contact Info

Product

Resources

About