Accumulation and immunotoxicity of microplastics in the estuarine worm Hediste diversicolor in environmentally relevant conditions of exposure

Revel, Messika; Yakovenko, Nadiia; Caley, Timothy; Guillet, Catherine; Châtel, Amélie; Mouneyrac, Catherine

doi:10.1007/s11356-018-3497-6

Cited by 66 publications

(29 citation statements)

References 47 publications

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“…Other microplastics have been studied individually. Polyethylene and PP fragments (< μm, 0.008 to 100 μg/L, for 10 days) did not show significant immune damage in ragworm and oyster [106,107]. Specific dysregulation of proteins involved in immune response were observed in hemolymph of mussels exposed to PE and polylactic acid microplastics (845 and 1296 particles/L respectively, 2 h/day, for 52 days) [108].…”

Section: In Vivo Immunotoxicity Of Nano-and Microplastics In Invertebmentioning

confidence: 90%

Immunotoxicity and intestinal effects of nano- and microplastics: a review of the literature

2020

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Background Together with poor biodegradability and insufficient recycling, the massive production and use of plastics have led to widespread environmental contamination by nano- and microplastics. These particles accumulate across ecosystems - even in the most remote habitats - and are transferred through food chains, leading to inevitable human ingestion, that adds to the highest one due to food processes and packaging. Objective The present review aimed at providing a comprehensive overview of current knowledge regarding the effects of nano- and microplastics on intestinal homeostasis. Methods We conducted a literature search focused on the in vivo effects of nano- and microplastics on gut epithelium and microbiota, as well as on immune response. Results Numerous animal studies have shown that exposure to nano- and microplastics leads to impairments in oxidative and inflammatory intestinal balance, and disruption of the gut’s epithelial permeability. Other notable effects of nano- and microplastic exposure include dysbiosis (changes in the gut microbiota) and immune cell toxicity. Moreover, microplastics contain additives, adsorb contaminants, and may promote the growth of bacterial pathogens on their surfaces: they are potential carriers of intestinal toxicants and pathogens that can potentially lead to further adverse effects. Conclusion Despite the scarcity of reports directly relevant to human, this review brings together a growing body of evidence showing that nano- and microplastic exposure disturbs the gut microbiota and critical intestinal functions. Such effects may promote the development of chronic immune disorders. Further investigation of this threat to human health is warranted.

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Section: In Vivo Immunotoxicity Of Nano-and Microplastics In Invertebmentioning

confidence: 90%

Immunotoxicity and intestinal effects of nano- and microplastics: a review of the literature

2020

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“…Many studies have used pristine plastic particles obtained from commercial products in their experiments rather than particles derived from fragmentation typically encountered in plastic pollution, thereby limiting the environmental relevance of experimental outcomes (Sussarellu et al, 2016;Magni et al, 2018;De Felice et al, 2019;O'Donovan et al, 2019). There has been significant progress made in understanding the toxicity of plastic particles themselves, including a growing body of research investigating environmentally representative plastics, often with mixed results (which may be attributed to the large variation in MNPs and measured endpoints) regarding effects in both terrestrial and aquatic environmental compartments (Connors, Dyer & Belanger, 2017;Booth et al, 2019;Revel et al, 2020aRevel et al, , 2020b. Research on more environmentally representative, irregular pieces of plastics composed of polyethylene terephthalate (PET), polyvinyl chloride (PVC), polyethylene (high density and low density) and some polyamides is also available, but the use of the outcomes is often limited due to inconsistent results and an absence of standardized methods.…”

Section: Overview Of Ecotoxicity On Micro(nano)plastics and Current Lmentioning

confidence: 99%

“…Research on aquatic organisms demonstrated that both micro and nano plastics produce effects at sub individual levels of biological organization with limited Full-size  DOI: 10.7717/peerj.11300/fig- 1 impact due to polymer type, suggesting that many observed effects may be due to processes of physical obstruction. These include blockages and internal abrasion of tissues, like digestive systems, can be linked to reduced energy intake and inflammation (Besseling et al, 2013;Cole et al, 2013;Wright, Thompson & Galloway, 2013;Guzzetti et al, 2018;Trevisan et al, 2019;Yuan et al, 2019;Revel et al, 2020b). Similarly, assessments made with terrestrial organisms have demonstrated that plastics particles can interact with certain species via ingestion (worms and gastropods) leading to mechanical alterations, such as gut obstruction, which can decrease food assimilation and result in growth inhibition (Huerta Lwanga et al, 2016;Rodriguez-Seijo et al, 2017;Zhu et al, 2018;Wang et al, 2019;Jiang et al, 2020).…”

Section: Physical and Effects Of Micro(nano)plastics In The Environmentmentioning

confidence: 99%

Plastic additives: challenges in ecotox hazard assessment

Barrick

Champeau

Châtel

et al. 2021

PeerJ

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The risk of plastic debris, and specifically micro(nano)plastic particles, to ecosystems remains to be fully characterized. One particular issue that warrants further characterization is the hazards associated with chemical additives within micro(nano)plastic as they are not chemically bound within the polymers and can be persistent and biologically active. Most plastics contain additives and are therefore potential vectors for the introduction of these chemicals into the environment as they leach from plastic, a process that can be accelerated through degradation and weathering processes. There are knowledge gaps on the ecotoxicological effects of plastic additives and how they are released from parent plastic materials as they progressively fragment from the meso to micro and nano scale. This review summarizes the current state of knowledge of the ecotoxicity of plastic additives and identifies research needs to characterize the hazard they present to exposed biota. The potential ecological risk of chemical additives is of international concern so key differences in governance between the European Union and New Zealand to appropriately characterize their risk are highlighted.

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“…PS microplastics also increased the acetylcholinesterase (AChE) activity and the related neurotransmitters such as threonine, aspartate, and taurine in a mouse model [122]. In addition, microplastics and nanoplastics elicit immunological responses [115,123,124], alter gene expression [88,103,113,114,125] and induce genotoxicity [113,126]. In kidney cells, VC stimulates the expression of fibrosis-related proteins, such as CTGF, PAI-1, and collagen 1, and autophagy-related proteins, such as Beclin 1 and LC3-II [127].…”

Section: Molecular and Cellular Mechanisms Of Plastic Micromaterials Amentioning

confidence: 99%

Potent Impact of Plastic Nanomaterials and Micromaterials on the Food Chain and Human Health

Wang

Lee

Chiu

et al. 2020

IJMS

138

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Plastic products are inexpensive, convenient, and are have many applications in daily life. We overuse plastic-related products and ineffectively recycle plastic that is difficult to degrade. Plastic debris can be fragmented into smaller pieces by many physical and chemical processes. Plastic debris that is fragmented into microplastics or nanoplastics has unclear effects on organismal systems. Recently, this debris was shown to affect biota and to be gradually spreading through the food chain. In addition, studies have indicated that workers in plastic-related industries develop many kinds of cancer because of chronic exposure to high levels of airborne microplastics. Microplastics and nanoplastics are everywhere now, contaminating our water, air, and food chain. In this review, we introduce a classification of plastic polymers, define microplastics and nanoplastics, identify plastics that contaminate food, describe the damage and diseases caused by microplastics and nanoplastics, and the molecular and cellular mechanisms of this damage and disease as well as solutions for their amelioration. Thus, we expect to contribute to the understanding of the effects of microplastics and nanoplastics on cellular and molecular mechanisms and the ways that the uptake of microplastics and nanoplastics are potentially dangerous to our biota. After understanding the issues, we can focus on how to handle the problems caused by plastic overuse.

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Accumulation and immunotoxicity of microplastics in the estuarine worm Hediste diversicolor in environmentally relevant conditions of exposure

Cited by 66 publications

References 47 publications

Immunotoxicity and intestinal effects of nano- and microplastics: a review of the literature

Immunotoxicity and intestinal effects of nano- and microplastics: a review of the literature

Plastic additives: challenges in ecotox hazard assessment

Potent Impact of Plastic Nanomaterials and Micromaterials on the Food Chain and Human Health

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