Accumulation and metabolism of di(n-butyl) phthalate (DBP) and di(2-ethylhexyl) phthalate (DEHP) in mature wheat tissues and their effects on detoxification and the antioxidant system in grain

Gao, Minling; Xu, Yalei; Dong, Youming; Song, Zhengguo; Liu, Ying

doi:10.1016/j.scitotenv.2019.133981

Cited by 45 publications

(7 citation statements)

References 27 publications

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“…The wide use of plastic products containing plasticizers, including plastic film and greenhouse covers, resulted in plenty of DEHP being released to farmland and concentrated in soils. , DEHP presents the highest concentration in the soil among the PAEs, and the half-life of DEHP is estimated to be 50–300 days . DEHP are taken up and accumulated by numerous plants including cauliflower, lettuce, and wheat in contaminated soils. Epidemiological findings indicated that DEHP could result in damage to the human endocrine system via inducing male reproductive disorders or diseases. , Animal studies have indicated that DEHP promoted Leydig cell proliferation and suppressed differentiation when Leydig cells regenerated .…”

Section: Discussionmentioning

confidence: 99%

Lycopene Prevents DEHP-Induced Leydig Cell Damage with the Nrf2 Antioxidant Signaling Pathway in Mice

Zhao¹,

Li²,

Shen³

et al. 2019

J. Agric. Food Chem.

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As a plasticizer, di(2-ethylhexyl) phthalate (DEHP) is the most usually used phthalate. Leydig cell is a male-specific cell, which plays a principal role in spermatogenesis and masculinization by the androgens of synthesis and secretion. Numerous researchers have indicated that DEHP can result in testicular toxicity by inducing oxidative stress. Lycopene (LYC) is a possible treatment option for male infertility due to its natural antioxidant properties. Our study was aimed to investigate whether LYC could rescue DEHP-induced Leydig cell damage. The mice were treated with DEHP (500 mg/kg BW/day or 1000 mg/kg BW/day) and/or LYC (5 mg/kg BW/day) for 28 days. We found that LYC attenuated DEHP-induced Leydig cell damage. Moreover, the protective role of LYC was verified by the histopathological and ultrastructural analysis of the Leydig cell. LYC suppressed oxidative stress that was induced by DEHP. In the Leydig cell, the expressions of the nuclear factor erythroid 2-related factor 2 (Nrf2) and its downstream target genes were improved through LYC-mediated protection in DEHP-induced Leydig cell damage. Our findings indicated that LYC could increase the antioxidant capacity via mediating Nrf2 signaling pathway, thereby attenuating DEHP-induced Leydig cell damage.

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Section: Discussionmentioning

confidence: 99%

Lycopene Prevents DEHP-Induced Leydig Cell Damage with the Nrf2 Antioxidant Signaling Pathway in Mice

Zhao¹,

Li²,

Shen³

et al. 2019

J. Agric. Food Chem.

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“…This can help to understand the essential mechanisms of their migration and accumulation in the soil–plant system. It is noteworthy that PAEs can enter carrots via root absorption and passive diffusion and then dynamically accumulate in different tissues by time to time, which has a great impact on the growth, metabolism, physiology, and biochemistry of carrots. , Unfortunately, the MALDI-TOF-MS used in this study could identify plant metabolites, but not quantify them accurately. Next, we plan to fine-tune the MALDI-IMS technique using MALDI–Q-TOF-MS for identifying and quantifying plant metabolites and use it in tandem with physiological, transcriptomic, and metabolomic analyses to investigate how carrots react to PAE pollution.…”

Section: Resultsmentioning

confidence: 94%

Visualizing the Distribution of Phthalate Esters and Plant Metabolites in Carrot by Matrix-Assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Xiang

Wang

Bian

et al. 2022

J. Agric. Food Chem.

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The accumulation of organic pollutants in vegetables is a major global food safety issue. The concentrations of pollutants in vegetables usually differ across different tissues because of different transport and accumulation pathways. However, owing to the limitations of conventional methods, in situ localization of typical organic pollutants such as phthalate esters (PAEs) in plant tissues has not yet been studied. Here, we developed a quick and efficient method for in situ detection and imaging of the spatial distribution of PAEs in a typical root vegetable, carrot, using matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI-IMS). The use of a 2,5-dihydroxybenzoic acid matrix with a spray−sublimation coating method led to the successful identification of PAEs ion signals. The IMS results showed that a typical PAE−di-(2-ethylhexyl)phthalate (DEHP) was broadly distributed in the cortex, phloem, and metaxylem, but was barely detectable in the cambium and protoxylem. Interestingly, MALDI-IMS data also revealed for the first time the spatial distribution of sugars and β-carotene in carrots. In summary, the developed method offers a new and practical methodology for the in situ analysis of PAEs and plant metabolites in plant tissues. As a result, it could provide a more intuitive understanding of the movement and transformation of organic pollutants in soil−plant systems.

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“…Over 90% of produced plasticizers are used to enhance PVC properties, expected to reach 59 million tons in 2020 [ 92 , 93 ]. Phthalic acid esters are the most used plasticizers globally, di(2-ethylhexyl) phthalate (DEHP) being the most pervasive plasticizer added to plastic [ 94 ]. Phthalates are not covalently associated with the polymeric matrix, and the mechanical wearing of the plastic product allows its migration to food and the environment [ 93 ].…”

Section: Environmental Impact and Health Effects Of Synthetic Plastic...mentioning

confidence: 99%

Towards a Circular Economy of Plastics: An Evaluation of the Systematic Transition to a New Generation of Bioplastics

et al. 2022

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Plastics have become an essential part of the modern world thanks to their appealing physical and chemical properties as well as their low production cost. The most common type of polymers used for plastic account for 90% of the total production and are made from petroleum-based nonrenewable resources. Concerns over the sustainability of the current production model and the environmental implications of traditional plastics have fueled the demand for greener formulations and alternatives. In the last decade, new plastics manufactured from renewable sources and biological processes have emerged from research and have been established as a commercially viable solution with less adverse effects. Nevertheless, economic and legislative challenges for biobased plastics hinder their widespread implementation. This review summarizes the history of plastics over the last century, including the most relevant bioplastics and production methods, the environmental impact and mitigation of the adverse effects of conventional and emerging plastics, and the regulatory landscape that renewable and recyclable bioplastics face to reach a sustainable future.

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Accumulation and metabolism of di(n-butyl) phthalate (DBP) and di(2-ethylhexyl) phthalate (DEHP) in mature wheat tissues and their effects on detoxification and the antioxidant system in grain

Cited by 45 publications

References 27 publications

Lycopene Prevents DEHP-Induced Leydig Cell Damage with the Nrf2 Antioxidant Signaling Pathway in Mice

Lycopene Prevents DEHP-Induced Leydig Cell Damage with the Nrf2 Antioxidant Signaling Pathway in Mice

Visualizing the Distribution of Phthalate Esters and Plant Metabolites in Carrot by Matrix-Assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Towards a Circular Economy of Plastics: An Evaluation of the Systematic Transition to a New Generation of Bioplastics

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