Accumulation, Distribution, and Excretion of Mirex-I4C in Animals Exposed for Long Periods to the Insecticide in the Diet

Gw, Ivie; Gibson,; He, Baoxia; Jj, Begin; Barnett, David; Hw, Dorough

doi:10.1021/jf60194a054

Cited by 43 publications

(18 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There was a dose-related increase in the levels of mirex found in the fat of rats fed 0.02, 0.2, or 1.5 mg/kg/day for 16 months (Ivie et al, 1974b). The mirex levels in the fat were 120-fold higher than the corresponding dietary intakes.…”

Section: Distributionmentioning

confidence: 88%

“…No plateau of residue accumulation occurred in any tissue during the feeding period. Removal of animals from treatment after six months resulted in a decline of residue levels in all tissues (Ivie et al, 1974b).…”

Section: Distributionmentioning

confidence: 98%

“…In animals, mirex is excreted unchanged mainly in the feces; urinary excretion is negligible (Gibson et al, 1972;Ivie et al, 1974b;Byrd et al, 1982;Chambers et al, 1982). Female rats receiving a single oral dose of 14C-mirex (0.2 mg/kg) excreted 18% of the total administered dose in the feces (Gibson et al, 1972).…”

Section: Distributionmentioning

confidence: 99%

“…Mirex is a highly stable, lipophilic compound that is resistant to metabolism. It has a high lipid:water partition coefficient (HSDB, 1992a,b), so it partitions readily to fat and demonstrates a very high potential for accumulation in tissues (Ivie et al, 1974b;Chambers et al, 1982).…”

Section: Mechanisms Of Actionmentioning

confidence: 99%

See 3 more Smart Citations

Atsdr Evaluation of Health Effects of Chemicals

et al. 1995

View full text Add to dashboard Cite

This document provides public health officials, physicians, toxicologists, and other interested individuals and groups with an overall perspective of the toxicology of mirex and chlordecone. It contains descriptions and evaluations of toxicological studies and epidemiological investigations and provides conclusions, where possible, on the relevance of toxicity and toxicokinetic data to public health. Additional substances will be profiled in a series of manuscripts to follow.

show abstract

Section: Distributionmentioning

confidence: 88%

Section: Distributionmentioning

confidence: 98%

Section: Distributionmentioning

confidence: 99%

Section: Mechanisms Of Actionmentioning

confidence: 99%

See 2 more Smart Citations

Atsdr Evaluation of Health Effects of Chemicals

et al. 1995

View full text Add to dashboard Cite

show abstract

“…One or more of such promotion mechanisms might explain the carcinogenicity of the insecticide mirex, which is reported to be a hepa to carcinogen in mice (34 ), even though there is strong evidence that laboratory rodents are unable to metabolize this insecticide (35,36). Laboratory rodents, in fact, appear to be poor metabolic predictors for man!…”

Section: Pesticide Conjugatesmentioning

confidence: 99%

Metabolic Aspects of Pesticide Toxicology

Gw¹,

Sk²

1981

ACS Symposium Series

View full text Add to dashboard Cite

At least 1500 organic and inorganic chemicals are used in a manner such that they can be called pesticides (1). These chemicals are indispensable in the management of a seemingly endless variety of pest organisms, including insects, weeds, fungi, bacteria, pest birds and mammals, and others.Pesticides are intentionally applied to many components of the environment, and they or their degradation products often move quite freely through the environment by mechanisms such as runoff, leaching, and volatilization. The production and use of pesticides on a world scale exceeds 3 billion pounds annually (1), and it can safely be said that residues of various pesticides interact at some level with virtually all components of the environment.Pesticides by design are meant to be toxic! Although a major goal of the discipline of modern pesticide chemistry is to develop pesticides and consequent use patterns that confine pesticide toxicity to pest organisms, such a goal is seldom attained easily. All living organisms have much in common biochemically, and successful exploitation of the often relatively minor biochemical differences between pest and non-pest species is almost always difficult and is, in fact, sometimes impossible.Thus, it is often necessary to use pesticides that are toxic not only to the pest species but to other organisms as well. Even when we succeed in developing what appear to be highly efficacious yet selective pesticides, we are always concerned that interactions of these chemicals or their transformation products with non-target species, particularly man, may result in some unforeseen toxic consequences.From the human perspective, the direct toxicological implications of pesticide use to our own species merit the most thorough and serious consideration. Most would agree that the judicious use of pesticides contributes in a positive way to many aspects of human welfare, but we also recognize that these chemicals have genuine potential for adverse human effects.Therefore, if the proposed use patterns of a pesticide create a substantial likelihood that interactions with man may occur, it is prudent to

show abstract

Dynamics of organochlorine compounds in herring gulls (Larus argentatus): II. A two‐compartment model and data for ten compounds

Clark¹,

Norstrom²,

Fox³

et al. 1987

Enviro Toxic and Chemistry

View full text Add to dashboard Cite

A two‐compartment open model using plasma and seasonally variable lipid compartments was developed and validated for several organochlorines in herring gulls (Larus argentatus). Plasma clearance rate constants (k′pc, L·kg−1·d−1), plasma: whole‐body lipid partition coefficients (Kpf) and compartment sizes for lipid and plasma were obtained for juvenile gulls injected i.p. with a mixture of p,p′‐DDD, p,p′‐DDE, hexachlorobenzene, oxychlordane, γ‐hexachlorocyclohexane, trans‐chlordane, octachlorostyrene, dieldrin, mirex and photomirex. Concentrations in plasma were determined at 11 time points during the 239‐d study, and whole‐body contaminant burdens and lipid weights were determined at 3 time points. Mean Kpf for p,p′‐DDD and p,p′‐DDE (0.0038 ± 0.0002) was different from that of the other organochlorines (0.0058 ± 0.0005, n = 7). The latter values were close to the expected fraction lipid in plasma, indicating a simple thermodynamic partitioning between lipid pools in adipose tissue and plasma. Plasma clearance rate constants ranged from approximately 0.04 L·kg−1·d−1 for slowly clearing organochlorines such as p,p′‐DDE and mirex to 500 L·kg−1·d−1 for rapidly clearing γ‐hexachlorocyclohexane and trans‐chlordane. Simulations using these parameters and lipid weight regimes for individual experimental birds tracked observed plasma concentrations and final body burdens closely. Simulated whole‐body half‐lives of organochlorines in wild adult gulls were similar to those published for other species.

show abstract

Accumulation, Distribution, and Excretion of Mirex-I4C in Animals Exposed for Long Periods to the Insecticide in the Diet

Cited by 43 publications

References 4 publications

Atsdr Evaluation of Health Effects of Chemicals

Atsdr Evaluation of Health Effects of Chemicals

Metabolic Aspects of Pesticide Toxicology

Dynamics of organochlorine compounds in herring gulls (Larus argentatus): II. A two‐compartment model and data for ten compounds

Contact Info

Product

Resources

About