Accumulation of bisphosphonates in the aorta and some other tissues of healthy and atherosclerotic rabbits

The effects of zoledronic acid on neointimal hyperplasia: a rabbit carotid anastomosis model

“…Our finding supports the view that bisphosphonates not only bind tightly to hydroxyapatite in the bone but they also concentrate in the arterial wall of both healthy and especially atheromatous rabbits (20). Furthermore, the inhibitory effect of ZA on SMC score suggests that ZA might also have direct inhibitory effect on vascular SMCs.…”

“…In most of the studies related to bisphosphonates have been shown to have inhibitory effects on MMP production and activities during tumor growth and invasion. Besides, it was reported that bisphosphonates inhibit SMC proliferation and migration in atherosclerotic animal models and cell culture (16)(17)(18)(19)(20).…”

Identification of Dynamin-2-Mediated Endocytosis as a New Target of Osteoporosis Drugs, Bisphosphonates

“…However, a few studies have shown that some of the drug also accumulates temporarily in soft tissues, such as liver and spleen, and is subsequently released over a period of days (Stepensky et al, 2003), although its precise pharmacokinetics remains to be determined. In another study, it was suggested that bisphosphonate concentrations at the aorta are much higher (up to 24-fold) than plasma levels (Ylitalo et al, 1996). In addition, the deposition in soft tissues may vary by the mode of drug administration (Stepensky et al, 2003).…”

The Possible Influence of Bisphosphonate Therapy and Its Combination With Statins on Parameters of Aortic Stiffness in Women With Postmenopausal Osteoporosis

“…при этом, помимо взаимосвязи с динамикой центрального систоличе-ского давления, изменения спвкф были связаны с динами-кой маркеров костного обмена, что еще раз позволяет пред-положить наличие общих механизмов поражения сосудистой стенки и костной ткани. исследованиями показано, что бис-фосфонаты накапливаются в атеросклеротических бляшках аорты, бедренных артерий [43] и в непораженной аорте [44]. хотя бисфосфонаты могут связываться с высокой аффинно-стью с кальцием в асб, также они могут фагоцитироваться макрофагами [45], что препятствует формированию пени-стых клеток [46].…”