Accumulation of nanoplastics in human cells as visualized and quantified by hyperspectral imaging with enhanced dark-field microscopy

Zhang, Hongjie; Zhou, Haoran; Pan, Wei; Wang, Chuan; Liu, Yueyue; Yang, Liuyan; Tsui, Martin Tsz‐Ki; Miao, Ai-Jun

doi:10.1016/j.envint.2023.108134

Environment International

2023

DOI: 10.1016/j.envint.2023.108134

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Accumulation of nanoplastics in human cells as visualized and quantified by hyperspectral imaging with enhanced dark-field microscopy

Hongjie Zhang¹,

Haoran Zhou²,

Wei Pan³

et al.

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2024

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Cited by 8 publications

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Genotoxic and neurotoxic potential of intracellular nanoplastics: A review

Casella,

Ballaz

2024

J of Applied Toxicology

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Plastic waste comprises polymers of different chemicals that disintegrate into nanoplastic particles (NPLs) of 1–100‐nm size, thereby littering the environment and posing a threat to wildlife and human health. Research on NPL contamination has up to now focused on the ecotoxicology effects of the pollution rather than the health risks. This review aimed to speculate about the possible properties of carcinogenic and neurotoxic NPL as pollutants. Given their low‐dimensional size and high surface size ratio, NPLs can easily penetrate biological membranes to cause functional and structural damage in cells. Once inside the cell, NPLs can interrupt the autophagy flux of cellular debris, alter proteostasis, provoke mitochondrial dysfunctions, and induce endoplasmic reticulum stress. Harmful metabolic and biological processes induced by NPLs include oxidative stress (OS), ROS generation, and pro‐inflammatory reactions. Depending on the cell cycle status, NPLs may direct DNA damage, tumorigenesis, and lately carcinogenesis in tissues with high self‐renewal capabilities like epithelia. In cells able to live the longest like neurons, NPLs could trigger neurodegeneration by promoting toxic proteinaceous aggregates, OS, and chronic inflammation. NPL genotoxicity and neurotoxicity are discussed based on the gathered evidence, when available, within the context of the intracellular uptake of these newcomer nanoparticles. In summary, this review explains how the risk evaluation of NPL pollution for human health may benefit from accurately monitoring NPL toxicokinetics and toxicodynamics at the intracellular resolution level.

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Genotoxic and neurotoxic potential of intracellular nanoplastics: A review

Casella,

Ballaz

2024

J of Applied Toxicology

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Nanoplastic at environmentally relevant concentrations induces toxicity across multiple generations associated with inhibition in germline G protein-coupled receptor CED-1 in Caenorhabditis elegans

Wu,

Shao,

Hua

et al. 2024

Chemosphere

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Smartphone analysis and dark-field microscopy observation for aflatoxin B1 detection based on the disintegration of core-shell Ag@Au nanoparticles

Zhao,

Xie,

Chen

et al. 2024

Food Bioscience

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Accumulation of nanoplastics in human cells as visualized and quantified by hyperspectral imaging with enhanced dark-field microscopy

Cited by 8 publications

References 46 publications

Genotoxic and neurotoxic potential of intracellular nanoplastics: A review

Genotoxic and neurotoxic potential of intracellular nanoplastics: A review

Nanoplastic at environmentally relevant concentrations induces toxicity across multiple generations associated with inhibition in germline G protein-coupled receptor CED-1 in Caenorhabditis elegans

Smartphone analysis and dark-field microscopy observation for aflatoxin B1 detection based on the disintegration of core-shell Ag@Au nanoparticles

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