Accumulation of p53 is associated with tumour progression in cutaneous lesions of renal allograft recipients

Stark, Lesley A.; Arends, Mark J.; McLaren, K M; Benton, E. C.; Shahidullah, Hossain; Hunter, John; Bird, C. C.

doi:10.1038/bjc.1994.367

Cited by 18 publications

(5 citation statements)

References 51 publications

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“…This observation might suggest presence of mutations in the p53 tumour suppressor gene in these tumours, as p53 overexpression has been linked to certain p53 mutations ( Benjamin et al , 2008 ; Kusters-Vandevelde et al , 2010 ). However, a high level of detectable p53 protein has also been observed without detectable p53 mutations ( Stark et al , 1994 ).…”

Section: Discussionmentioning

confidence: 99%

High-risk human papillomavirus in non-melanoma skin lesions from renal allograft recipients and immunocompetent patients

et al. 2011

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Background:High-risk human papillomaviruses (HR-HPVs) can be detected in a proportion of non-melanoma skin cancers. Data on prevalence are inconclusive, but are essential to estimate the relevance of HR-HPV, particularly with regard to prophylactic HPV vaccines for skin cancer prevention.Methods:High-risk human papillomavirus DNA was investigated in 140 non-melanoma skin lesions from 54 immunocompetent patients and 33 immunosuppressed renal allograft recipients. Expression of p16INK4a, a marker for HR-HPV oncogene expression in the uterine cervix, and of p53 and pRB was evaluated immunohistochemically.Results:The highest prevalence of HR-HPV was found in squamous cell cancer (SCC) (46.2% (6 out of 13) in immunosuppressed and 23.5% (4 out of 17) in immunocompetent patients). High-risk human papillomavirus positivity was accompanied by diffuse p16INK4a expression in most SCC (P<0.001) and basal cell cancers (P=0.02), while almost all SCC in situ were p16INK4a positive irrespective of HR-HPV presence (P=0.66). Diffuse p16INK4a expression was associated with lack of pRB expression (P=0.001). p53 was strongly expressed in 40.0% (56 out of 140) of the lesions irrespective of HR-HPV presence.Conclusion:High-risk human papillomavirus can be detected in lesions of keratinised squamous epithelia. The association of HR-HPV with diffuse p16INK4a expression might indicate HR-HPV oncogene expression in a proportion of lesions. Overexpression of p53 suggests p53 pathway alterations in HR-HPV-positive and -negative lesions.

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Section: Discussionmentioning

confidence: 99%

High-risk human papillomavirus in non-melanoma skin lesions from renal allograft recipients and immunocompetent patients

et al. 2011

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“…However, in contrast to their reports, our study showed a higher prevalence of p53, and more extensive p53 immunoreactivity, in DEKs from RTRs compared to similar lesions from the general population. 16,17 Assuming that accumulation of p53 does, in fact, represent an important step in tumor progression, 18 it is possible that our results may indicate an easier progression of premalignant lesions to SCC in RTRs than in ICIs. This might explain the increased incidence of skin cancer in renal transplant recipients.…”

Section: Discussionmentioning

confidence: 88%

P53 Immunohistochemical Expression in Early Posttransplant-Associated Malignant and Premalignant Cutaneous Lesions

Ferrándiz¹,

Fuente²,

Fernández‐Figueras³

et al. 1999

Dermatologic Surgery

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“…Point mutations are seen in early stages of skin cancer; allelic loss enhances tumor growth with high exposure to UV radiation and enhances progression of the malignancy 9 . p53 mutations have also been seen in the SCCs of renal allograft recipients, present in approximately 56% of SCCs according to Stark and colleagues 10 …”

Section: Etiologymentioning

confidence: 99%

Lasers in the Treatment of Nonmelanoma Skin Cancer

Choudhary

Tang

Elsaie

et al. 2011

Dermatologic Surgery

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Accumulation of p53 is associated with tumour progression in cutaneous lesions of renal allograft recipients

Cited by 18 publications

References 51 publications

High-risk human papillomavirus in non-melanoma skin lesions from renal allograft recipients and immunocompetent patients

High-risk human papillomavirus in non-melanoma skin lesions from renal allograft recipients and immunocompetent patients

P53 Immunohistochemical Expression in Early Posttransplant-Associated Malignant and Premalignant Cutaneous Lesions

Lasers in the Treatment of Nonmelanoma Skin Cancer

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