Accumulation of polychlorinated organic contaminants from sediment by three benthic marine species

Pruell, Richard J.; Rubinstein, Norman I.; Taplin, Bryan K.; LiVolsi, J.A.; Bowen, Robert D.

doi:10.1007/bf01128727

Cited by 92 publications

(75 citation statements)

References 27 publications

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“…BSAF values were generally comparable for the same analytes between the two sediment exposures, with discrepancies for total 2,3,7,8-TCDD, 2,3,7,8-TCDF, total TCDF, and total PeCDF. BSAF values previously reported for TCDD and TCDF ranged from 0.11 to 0.50 (Pruell et al 1993;Schrock et al 1997) and were overall similar to the steady state BSAFs obtained in this study. .…”

Section: Erdc/el Tr-10-2 33supporting

confidence: 75%

“…An additional study by Drouillard et al (2008) For N. virens, the 28-d and steady-state BSAFs were similar among congeners and between the Arthur Kill and Newark Bay sediment exposures ( Figure 16). The BSAFs obtained in this study were lower overall compared to previously reported values (0.19-1.41) (Pruell et al 1993 Ferraro et al 1990Ferraro et al , 1991Brannon et al 1993;Pruell et al 1993;Boese et al 1995Boese et al , 1996. Overall, the BSAFs obtained in this study for M. nasuta were lower compared to previously reported values.…”

Section: Polychlorinated Biphenyls (Pcbs)contrasting

confidence: 55%

“…The high TSS reported for PCB 118 (390 days) in the Arthur Kill exposure should be interpreted with caution provided the 119-d tissue residue was almost twofold greater than the apparently stable 28-through 90-d time tissue residue (Appendix D2). Pruell et al (1990Pruell et al ( , 1993 reported relatively slow acquisition of steady state for N. virens but fast uptake for M. nasuta exposed to PCBs based on statistical comparison between time points (Figure 14). The average mass of the N. virens (3.97  1.35 g) and M. nasuta (1.87  0.37 g), reported in Pruell et al (1993), was similar to the current study (see methods section), suggesting similar kinetics.…”

Section: Polychlorinated Biphenyls (Pcbs)mentioning

confidence: 99%

“…Pruell et al (1990Pruell et al ( , 1993 reported relatively slow acquisition of steady state for N. virens but fast uptake for M. nasuta exposed to PCBs based on statistical comparison between time points (Figure 14). The average mass of the N. virens (3.97  1.35 g) and M. nasuta (1.87  0.37 g), reported in Pruell et al (1993), was similar to the current study (see methods section), suggesting similar kinetics. These findings contrast with the Arthur Kill data set in this study, where uptake and elimination rates were much slower in M. nasuta relative to N. virens.…”

Section: Polychlorinated Biphenyls (Pcbs)mentioning

confidence: 99%

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Determining Steady-state Tissue Residues for Invertebrates in Contaminated Sediment

Kennedy¹,

Lotufo²,

Steevens³

et al. 2010

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Risk assessment of contaminated sediments often involves quantification of compounds in tissues via laboratory bioaccumulation exposures of benthic invertebrates. However, the standard 28-day exposure duration may not be adequately long for some compounds to reach steady state, defined as a stable concentration in exposed organisms. Steady-state tissue residues can be estimated using uptake and elimination rate constants. Experiments were conducted using two marine sediments from New York Harbor to assess bioaccumulation of PAHs, PCBs, chlorinated pesticides, dioxins, and Hg by sampling tissue during seven successive time points over an exposure of 56 days for the polychaete worm Nereis virens and 119 days for the clam Macoma nasuta. Exposure time required to attain steady state was organism and compound specific. Generally, N. virens tissues reached steady state more rapidly and accumulated higher contaminant residues. Nereis virens attained apparent steady state within roughly 28 days for PAHs, Hg, and most PCBs, but longer exposure was needed for some dioxins and pesticides. Steady state in M. nasuta was generally attained after 28 days of exposure for most compounds (some times after 100 days). Thus, some 28-day tissue residues may underestimate bioaccumulation and subsequently risk to benthos and higher trophic level organisms. The results of this study allow development of site-specific correction factors for estimating steady-state residues from 28-day exposures.

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Section: Erdc/el Tr-10-2 33supporting

confidence: 75%

Section: Polychlorinated Biphenyls (Pcbs)contrasting

confidence: 55%

Section: Polychlorinated Biphenyls (Pcbs)mentioning

confidence: 99%

Section: Polychlorinated Biphenyls (Pcbs)mentioning

confidence: 99%

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Determining Steady-state Tissue Residues for Invertebrates in Contaminated Sediment

Kennedy¹,

Lotufo²,

Steevens³

et al. 2010

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“…Elevated concentrations of PBDEs were found in herring gull eggs from the Great Lakes [45]. The presence of 2,4,6,8-tetrachlorodibenzothiophene (TCDT) in aquatic biota in the Hudson Raritan Estuary [46][47][48] also suggests the need to quantify polychlorinated dibenzothiophenes (PCDTs) in birds. The PHA skin response was negatively correlated with liver Se concentrations, but correlations with most dioxins and PCBs were stronger (Table 2).…”

Section: Potential Associations Of Immunotoxicity With Other Contaminmentioning

confidence: 99%

Immunological and reproductive health assessment in herring gulls and black‐crowned night herons in the Hudson–Raritan Estuary

Grasman

Echols

May

et al. 2013

Enviro Toxic and Chemistry

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Abstract-Previous studies have shown inexplicable declines in breeding waterbirds within western New York/New Jersey Harbor between 1996 and 2002 and elevated polychlorinated dibenzo-p-dioxins and polychlorinated biphenyls (PCBs) in double-crested cormorant (Phalacrocorax auritus) eggs. The present study assessed associations between immune function, prefledgling survival, and selected organochlorine compounds and metals in herring gulls (Larus argentatus) and black-crowned night herons (Nycticorax nycticorax) in lower New York Harbor during 2003. In pipping gull embryos, lymphoid cells were counted in the thymus and bursa of Fabricius (sites of T and B lymphocyte maturation, respectively). The phytohemagglutinin (PHA) skin response assessed T cell function in gull and heron chicks. Lymphocyte proliferation was measured in vitro in adult and prefledgling gulls. Reference data came from the Great Lakes and Bay of Fundy. Survival of prefledgling gulls was poor, with only 0.68 and 0.5 chicks per nest surviving to three and four weeks after hatch, respectively. Developing lymphoid cells were reduced 51% in the thymus and 42% in the bursa of gull embryos from New York Harbor. In vitro lymphocyte assays demonstrated reduced spontaneous proliferation, reduced T cell mitogen-induced proliferation, and increased B cell mitogen-induced proliferation in gull chicks from New York Harbor. The PHA skin response was suppressed 70 to 80% in gull and heron chicks. Strong negative correlations (r ¼ -0.95 to -0.98) between the PHA response and dioxins and PCBs in gull livers was strong evidence suggesting that these chemicals contribute significantly to immunosuppression in New York Harbor waterbirds. Environ. Toxicol. Chem. 2013;32:548-561. # 2012 SETAC

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Optimization of Marine Triterpene Sipholenols as Inhibitors of Breast Cancer Migration and Invasion

et al. 2013

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Sipholenol A, a sipholane triterpene isolated from the Red Sea sponge Callyspongia siphonella, has the ability to reverse multidrug resistance in cancer cells that overexpress P-glycoprotein (P-gp). Here, the antimigratory activity of sipholenol A and analogues are reported against the highly metastatic human breast cancer cell line MDA-MB-231 in a wound-healing assay. Sipholenol A and sipholenone A were semisynthetically optimized using ligand-based strategies to generate structurally diverse analogues in an attempt to maximize their antimigratory activity. A total of 22 semisynthetic ester, ether, oxime, and carbamate analogues were generated and identified by extensive one- and two-dimensional NMR spectroscopy and high-resolution mass spectrometry analyses. Sipholenol A 4β-4-chlorobenzoate and 19,20-anhydrosipholenol A 4β-4-chlorobenzoate esters were the most potent of all tested analogues in the wound-healing assay, with IC(50) values of 5.3 and 5.9 μM, respectively. Generally, ester derivatives showed better antimigratory activities than the carbamate analogues. A KINOMEscan of 19,20-anhydrosipholenol A 4β-benzoate ester against 451 human protein kinases identified protein tyrosine kinase 6 (PTK6) as a potential target. In breast tumor cells, PTK6 promotes growth factor signaling and migration, and as such the semisynthetic sipholanes were evaluated for their ability to inhibit PTK6 phosphorylation in vitro. The two analogues with the highest antimigratory activities, sipholenol A 4β-4-chlorobenzoate and 19,20-anhydrosipholenol A 4β-4-chlorobenzoate esters, also exhibited the most potent inhibition of PTK6 phosphorylation inhibition. None of the compounds exhibited cytotoxicity in a normal epithelial breast cell line. These derivatives were evaluated in an in vitro invasion assay, where sipholenol A succinate potently inhibited MDA-MB-231 cell invasion at 10 μM. These results highlight sipholane triterpenoids as novel antimigratory marine natural products with potential for further development as agents for the control of metastatic breast malignancies.

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Accumulation of polychlorinated organic contaminants from sediment by three benthic marine species

Cited by 92 publications

References 27 publications

Determining Steady-state Tissue Residues for Invertebrates in Contaminated Sediment

Determining Steady-state Tissue Residues for Invertebrates in Contaminated Sediment

Immunological and reproductive health assessment in herring gulls and black‐crowned night herons in the Hudson–Raritan Estuary

Optimization of Marine Triterpene Sipholenols as Inhibitors of Breast Cancer Migration and Invasion

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