Accumulation of sucrose polyesters in different organ lipids of rats in dependence on duration of application

Abstract

of sucrose and long chain fatty acids (SPE) are known as undigestible, unabborbable, fatlike compounds, which are potent substitutes for dietary fat in foodstuffs for reduction of energy intake. A long time application of SPE, however, requires that these esters are really unabsorbable and not incorporated (e.g. by pinocytosis) or, if absorbed to a small extent, they should be total metabolized. First results in a short time experiment (7 days) with rats fed with 14C-labelled sucrose-octa-palmitate outlined an average accumulation rate of 1 0 -~ toThe aim of this work was to verify the accumulation rate with higher amounts of highly purified labelled ester over a longer application time and to estimate the disappearance rate of radioactivity after changing to normal diet. percent in various organs [I].

Oxidation and accumulation of sucrose polyesters after i.v. application in rats (Short communication)

“…61. Earlier animal experiments with 64; '*C-labelled sucrose-octa-palmitate in a semisynthetic diet, however, outlined a very small but not neglectable accumulation raie of lO.-'--lO -5 0 ; in various organs after a feeding time of 7 days or 3 and 6 weeks, respectively [7,8).…”

“…61. Earlier animal experiments with 64; '*C-labelled sucrose-octa-palmitate in a semisynthetic diet, however, outlined a very small but not neglectable accumulation raie of lO.-'--lO -5 0 ; in various organs after a feeding time of 7 days or 3 and 6 weeks, respectively [7,8).Because nothing is known about metabolic fate of incorporated SPE the study aimed at the elucidation of the metabolic behaviour of SPE after i.v. injection to mimic a higher accumulation rate.…”