Accuracy and consequences of same-day, invasive lung cancer workup – a retrospective study in patients treated with surgical resection

Madsen, Kirsten Riis; Høegholm, Asbjørn; Bødtger, Uffe

doi:10.3402/ecrj.v3.32590

Cited by 6 publications

(4 citation statements)

References 31 publications

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“…(Silvestri et al, 2013; Lung Cancer Package Pathways in Denmark (Danish), 2018) Our unit offers single‐day invasive workup with bronchoscopy, endosonography and percutaneous biopsies. (Madsen et al, 2016; Sidhu et al, 2020).…”

Section: Methodsmentioning

confidence: 99%

Breaking potentially bad news of cancer workup to well‐informed patients by telephone versus in‐person: A randomised controlled trial on psychosocial consequences

et al. 2021

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Background The use of telephone in delivering cancer care increases, but not in cancer workup. Current protocols for breaking bad news assume a single in‐person meeting. Cancer workup involves multiple opportunities for patient information. We investigated the psychosocial consequences in gradually informed patients of receiving lung cancer workup results by telephone versus in‐person. Methods A randomised, controlled, open‐label, assessor‐blinded, single‐centre trial including patients referred for invasive workup for suspected malignancy (clinical trials no. NCT04315207). Patients were informed on probable cancer at referral, after imaging, and on the day of invasive workup (Baseline visit). Primary endpoint: change (Δ) from baseline to follow‐up (4 weeks after receiving workup results) in scores of a validated, sensitive, condition‐specific questionnaire (COS‐LC) assessing consequences on anxiety, behaviour, dejection and sleep. Results Of 492 eligible patients, we randomised 255 patients (mean age: 68 years; female: 38%; malignancy diagnosed: 68%) to the telephone (n = 129) or in‐person (n = 126) group. Groups were comparable at baseline and follow‐up, and no between‐groups difference in ΔCOS‐LC was observed in the intention‐to‐treat population, or in subgroups diagnosed with or without malignancy. Conclusion Breaking final result of cancer workup by telephone is not associated with adverse psychosocial consequences compared to in‐person conversation in well‐informed patients.

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Section: Methodsmentioning

confidence: 99%

Breaking potentially bad news of cancer workup to well‐informed patients by telephone versus in‐person: A randomised controlled trial on psychosocial consequences

et al. 2021

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“…Transthoracic sampling from lung lesions is performed guided by Ultra Sound (US), fluoroscopy or CT, and percutaneous non-lung lesions (e.g. peripheral lymph nodes, liver, spleen, skin) are reached by US-guided biopsy [5][6][7][8]. Whenever possible, histological biopsies were obtained (e.g.…”

Section: Biopsy Proceduresmentioning

confidence: 99%

Re-biopsy after first line treatment in advanced NSCLC can reveal changes in PD-L1 expression

et al. 2020

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Re-biopsy in progressive advanced Non-Small-Cell Lung Cancer (NSCLC) after first line treatment may reveal information about evolving tumor biology during treatment. Our study aims to investigate the feasibility, risk of complications, and clinical relevance of performing re-biopsy systematically. Materials and methods: NSCLC patients with advanced, non-targetable disease, receiving first line systemic treatment, were included in a prospective single-centre study (NCT03512847). A diagnostic biopsy was performed at baseline and repeated at time of progression, preferentially from the progressive lesions as determined by CT or PET/CT. The primary endpoint was feasibility, including complication rate to re-biopsy. Secondary endpoints were clinical relevance, defined as a potential of changing treatment or follow-up, due to new histological evidence, specifically a change in PD-L1 Tumor Proportion Score (TPS). Results: Fifty-one patients with progressive advanced NSCLC had re-biopsy performed. Median time from patients' acceptance to biopsy was seven days (range: 0-31). Complication rate was 6% (n = 3) represented by pneumothorax, hydro-pneumothorax and pneumonia, respectively. No severe or chronic complications occurred. Sufficient material for PD-L1 analyses was obtained in 46 of 51 patients: the remaining five cases had insufficient tissue for analyses, no malignant cells/only suspected malignant cells, questioning whether progression was real. PD-L1 TPS change was observed in 33% of patients (n = 15) and 17% (n = 8) had potentially clinically relevant changes. A significantly higher chance of PD-L1 TPS change was observed in chemotherapy-treated patients. Conclusion: Our study showed that re-biopsy is feasible, with low risk of complications, and can be clinically relevant in patients with suspected progression in advanced NSCLC.

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“…US-TTNB can be performed on patients with mechanical ventilation, but the potential clinical impact of obtaining the biopsy should outweigh the increased risk of pneumothorax and close monitoring is warranted. US-TTNB can be performed immediately after endoscopy, for example, as in combined single-day workup and staging of suspected lung cancer [18].…”

Section: Contraindicationsmentioning

confidence: 99%

Transthoracic ultrasound-guided biopsy in the hands of chest physicians – a stepwise approach

Christiansen

Clementsen

Bødtger

et al. 2019

European Clinical Respiratory Journal

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Background: The evaluation of patients with lung lesions is challenging. The nature of the lesion can be determined by pathological evaluation of biopsies. The pulmonologists will be met by increasing demands with regard to biopsy techniques including ultrasound-guided transthoracic needle biopsy (US-TTNB).Objective: The aim of this paper is to present the pulmonologist to a systematic step-by-step guide for performing US-TTNB and to assess the evidence for this approach. Method/results: Indications, contraindications and a step-by-step guide for the techniques used when performing US-TTNB are presented, and major complications and handling of these are described. Conclusion: US-TTNB performed by pulmonologists is a safe and feasible procedure. ARTICLE HISTORY

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Accuracy and consequences of same-day, invasive lung cancer workup – a retrospective study in patients treated with surgical resection

Cited by 6 publications

References 31 publications

Breaking potentially bad news of cancer workup to well‐informed patients by telephone versus in‐person: A randomised controlled trial on psychosocial consequences

Breaking potentially bad news of cancer workup to well‐informed patients by telephone versus in‐person: A randomised controlled trial on psychosocial consequences

Re-biopsy after first line treatment in advanced NSCLC can reveal changes in PD-L1 expression

Transthoracic ultrasound-guided biopsy in the hands of chest physicians – a stepwise approach

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