Accuracy and interobserver agreement of diffusion-weighted imaging in pediatric inflammatory bowel disease

AlSabban, Zehour; Church, Peter; Moineddin, Rahim; Navarro, Oscar M.; Greer, Mary‐Louise C.; Walters, Thomas D.; Chavhan, Govind

doi:10.1016/j.clinimag.2016.09.007

Cited by 11 publications

(6 citation statements)

References 19 publications

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“…Searches of the bibliographies of articles identified 1 additional eligible study . Full-text reviews of 48 potentially eligible articles were performed and 30 articles were excluded for the following reasons: 14 articles with insufficient data to reconstruct 2 × 2 tables, 10 articles that were not in the field of interest, 3 articles that included partially overlapping patient cohorts with other studies, and 3 articles that used clinical settings or imaging modalities other than histopathological findings as a reference standard . Finally, 18 original articles including a total of 687 patients evaluating the diagnostic performance of MR enterography for detection of active inflammation in patients with known or suspected IBD were included in our study …”

Section: Resultsmentioning

confidence: 99%

Diagnostic Performance of Magnetic Resonance Enterography for Detection of Active Inflammation in Children and Adolescents With Inflammatory Bowel Disease

Yoon

Suh²,

Kim

et al. 2017

JAMA Pediatr

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IMPORTANCE Magnetic resonance (MR) enterography has the advantage over other techniques of being noninvasive, lacking ionizing radiation, and demonstrating excellent soft-tissue contrast to evaluate pediatric patients with inflammatory bowel disease (IBD).OBJECTIVE To evaluate the diagnostic performance of MR enterography for detection of active inflammation in children and adolescents with known or suspected IBD.DATA SOURCES A search of MEDLINE and EMBASE up to January 2, 2017, was performed to identify studies. Search terms included child, pediatric, adolescent, Crohn disease, inflammatory bowel disease, and magnetic resonance enterography. The search was limited to English-language publications.STUDY SELECTION Studies evaluating the diagnostic performance of MR enterography for detection of active inflammation in pediatric patients with known or suspected IBD were selected. Two reviewers independently assessed the eligibility of the selected articles. DATA EXTRACTION AND SYNTHESISThe study was performed and reported in accordance with the PRISMA guidelines. Pooled summary estimates of sensitivity and specificity were calculated using hierarchical logistic regression modeling. MAIN OUTCOMES AND MEASURESThe diagnostic performance of MR enterography for detection of active inflammation in pediatric patients with known or suspected IBD was the primary outcome. Subgroup analyses and meta-regression were performed. RESULTSEighteen original articles involving a total of 687 patients were included. The summary sensitivity was 83% (95% CI, 75%-89%), the summary specificity was 93% (95% CI, 90%-95%), and the area under the hierarchical summary receiver operating characteristic curve was 0.95 (95% CI, 0.93-0.97). The Higgins I 2 statistics demonstrated substantial heterogeneity in terms of sensitivity (I 2 = 84.1%) and specificity (I 2 = 68.8%). Based on per-patient analysis, the summary sensitivity was 86% (95% CI, 78%-91%) and specificity was 91% (95% CI, 82%-96%). In meta-regression, among the various potential covariates, scanner manufacturer was associated with study heterogeneity.CONCLUSIONS AND RELEVANCE Magnetic resonance enterography, which is a noninvasive, radiation-free modality, demonstrates high diagnostic performance in the diagnosis of active inflammation in pediatric patients with IBD, especially at the per-patient level.

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Section: Resultsmentioning

confidence: 99%

Diagnostic Performance of Magnetic Resonance Enterography for Detection of Active Inflammation in Children and Adolescents With Inflammatory Bowel Disease

Yoon

Suh²,

Kim

et al. 2017

JAMA Pediatr

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“…Previous studies reported moderate to substantial inter-observer agreement between computed tomography (Horvat et al 2016) and/or magnetic resonance imaging (MRI) enterography (AlSabban et al 2017) intended to image inflammatory bowel diseases. Another study reported inter-observer agreement with k values of 0.22-0.85 for US evaluation of Crohn's disease and suggested that the poor reproducibility might be attributable to difficulties in recognizing the layered structure (Fraquelli et al 2008).…”

Section: Discussionmentioning

confidence: 99%

Validation of US evaluation of ulcerative colitis activity

Omotehara

Nishida

Kinoshita

et al. 2019

Ultrasound in Medicine & Biology

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This study was aimed at validating the inter-rater grading agreement for assessing disease activity in patients with established ulcerative colitis (UC) using transabdominal ultrasonography (US) versus colonoscopy (CS). Fiftyseven patients underwent US and CS at four facilities. UC disease activity was assessed using the original US grading system and CS Matts classification.Initially, the US and CS grades were assessed at each examining facility, and still images and movie clips were re-assessed at the central facility. Grading agreement between the examining and central facilities was evaluated. Grading agreement for US and CS were 0.75 and 0.72 in all segments and 0.82 and 0.70 in the maximum grade of each patient, respectively (all p < 0.001). US grading agreement was "almost perfect" for the maximum grade and "moderate" to "substantial" for other assessments. The inter-rater US grading agreement was good and not inferior to that of CS for evaluating UC disease activity.

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“…225 However, once trained, radiologists tend to maintain their interpretation skills long term. 226 Moderate-to-good interobserver agreement has been reported for MR enterography 77,226,227 and CT enterography, 228 with one study suggesting higher reader agreement for CT enterography over MR enterography. 229 There are also data that confirmed a learning curve in the interpretation of MRI perianal fistula imaging, with improvement in accuracy after dedicated training.…”

Section: Trainingmentioning

confidence: 99%

ECCO-ESGAR Guideline for Diagnostic Assessment in IBD Part 2: IBD scores and general principles and technical aspects

Sturm¹,

Maaser

Calabrese

et al. 2018

Journal of Crohn's and Colitis

326

217

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Accuracy and interobserver agreement of diffusion-weighted imaging in pediatric inflammatory bowel disease

Cited by 11 publications

References 19 publications

Diagnostic Performance of Magnetic Resonance Enterography for Detection of Active Inflammation in Children and Adolescents With Inflammatory Bowel Disease

Diagnostic Performance of Magnetic Resonance Enterography for Detection of Active Inflammation in Children and Adolescents With Inflammatory Bowel Disease

Validation of US evaluation of ulcerative colitis activity

ECCO-ESGAR Guideline for Diagnostic Assessment in IBD Part 2: IBD scores and general principles and technical aspects

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