“…9,11 Recently, similar to 2D cephalometric tracings, CBCT images can be superimposed, allowing a 3D evaluation of growth changes, treatment effects, and stability over a certain time interval through registration points, angles, shapes, and volumes. [12][13][14] One of the main challenges of 3D superimposition of serial images is to understand that linear/angular measurements in 2D and 3D images are not directly comparable because of differences in size, shape, and relative spatial location of the skeletal, dental, and soft tissue between the two imaging systems. 4,15 The following three general methods of 3D cephalometric superimposition have been published and used for clinical diagnosis and assessment of orthodontic treatment outcomes: (1) voxel based, 3,4,[16][17][18][19] (2) landmark based, 7,20 and (3) surface based.…”