Accuracy and validity of sentinel lymph node biopsy for breast cancer using a photosensitizer: 8-year follow-up

Yamada, Kimito; Ogata, Akihiko; Kojima, Hiroshi; Oda, Miki; Kimura, F.; Komatsu, Sumio; Nakamura, Yukiko; Hosonaga, Mari; Matsumura, Mayuko; Kawate, Takahiko; Miyahara, Kana; Kawai, Yuko; Ueda, Atsushi; Teraoka, Saeko; Kohno, Norio

doi:10.1002/lsm.22183

Cited by 3 publications

(6 citation statements)

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“…Sentinel lymph node biopsy using Laserphyrin ® in breast cancer patients is considered to be useful as a complementary method to other current methods. In 14 of 21 patients, the Laserphyrin ® method successfully detected sentinel nodes [ 85 ]. In these clinical trials, no side effects, including photosensitivity, were encountered.…”

Section: Breast Cancermentioning

confidence: 99%

Recent Studies in Photodynamic Therapy for Cancer Treatment: From Basic Research to Clinical Trials

Kim,

Chang

2023

Pharmaceutics

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Photodynamic therapy (PDT) is an emerging and less invasive treatment modality for various types of cancer. This review provides an overview of recent trends in PDT research, ranging from basic research to ongoing clinical trials, focusing on different cancer types. Lung cancer, head and neck cancer, non-melanoma skin cancer, prostate cancer, and breast cancer are discussed in this context. In lung cancer, porfimer sodium, chlorin e6, and verteporfin have shown promising results in preclinical studies and clinical trials. For head and neck cancer, PDT has demonstrated effectiveness as an adjuvant treatment after surgery. PDT with temoporfin, redaporfin, photochlor, and IR700 shows potential in early stage larynx cancer and recurrent head and neck carcinoma. Non-melanoma skin cancer has been effectively treated with PDT using methyl aminolevulinate and 5-aminolevulinic acid. In prostate cancer and breast cancer, PDT research is focused on developing targeted photosensitizers to improve tumor-specific uptake and treatment response. In conclusion, PDT continues to evolve as a promising cancer treatment strategy, with ongoing research spanning from fundamental investigations to clinical trials, exploring various photosensitizers and treatment combinations. This review sheds light on the recent advancements in PDT for cancer therapy and highlights its potential for personalized and targeted treatments.

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Section: Breast Cancermentioning

confidence: 99%

Recent Studies in Photodynamic Therapy for Cancer Treatment: From Basic Research to Clinical Trials

Kim,

Chang

2023

Pharmaceutics

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“…Talaporfin is injected at the subareolar region just before the operation, and the sentinel node is identified as 'pink' by using fluorescence with xenon light [4].…”

Section: Photosensitiser Talaporfin Sodiummentioning

confidence: 99%

“…The standard method of SLNB has thus far been dual: radioisotope and blue dye injection [18]. However, many countries worldwide do not have nuclear medicine facilities [4], and the need for preoperative radioisotope injections creates scheduling difficulties and the need for safe handling and disposal of these materials. Blue dye has been used for many years as a localisation technique, but it can cause skin staining for months to years and poses a potential allergy risk to patients.…”

Section: Computed Tomography Lymphography (Ctlg)mentioning

confidence: 99%

“…However, these methods come with significant disadvantages, including cost, risk of an allergic reaction, the need for a nuclear medicine department and scheduling of isotope injections preoperatively. In some countries, such as Japan, the lack of nuclear medicine facilities [4] has led to the development of alternative methods of SLNB. This review analyses the alternatives available, including their localisation outcomes, advantages and disadvantages.…”

Section: Introductionmentioning

confidence: 99%

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New Alternative Techniques for Sentinel Lymph Node Biopsy

Subramonian,

Chopra,

Vidya

2023

Medicina

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Background and Objectives: This review paper highlights the key alternatives to the blue dye/radioisotope method of sentinel lymph node biopsy (SLNB). It analyses the research available on these alternative methods and their outcomes compared to the traditional techniques. Materials and Methods: This review focused on fifteen articles, of which five used indocyanine green (ICG) as a tracer, four used magnetic tracers, one used one-step nucleic acid amplification (OSNA) and Metasin (quantitative reverse transcriptase-polymerase chain reaction), one used the photosensitiser talaporfin sodium, one used sulphur hexafluoride gas microbubbles, one used CT-guided lymphography and two focused on general SLNB technique reviews. Results: Of the 15 papers analysed, the sentinel node detection rates were 69–100% for indocyanine green, 91.67–100% for magnetic tracers, 81% for talaporfin sodium, 9.3–55.2% for sulphur hexafluoride gas microbubbles, 90.5% for CTLG and 82.7–100% for one-step nucleic acid amplification. Conclusions: Indocyanine green fluorescence (ICG) and magnetic tracers have been proven non-inferior to traditional blue dye and isotope regarding SLNB localisation. Further studies are needed to investigate the use of these techniques in conjunction with each other and the possible use of language learning models. Dedicated studies are required to assess cost efficacy and longer-term outcomes.

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“…Tais Após a absorção de um fóton de luz, o fármaco fotossensibilizante passa a popular um estado excitado singleto mais energético (S n ), de onde pode retornar ao seu estado fundamental (S 0 ) por meio do processo de relaxação física conhecido como conversão interna ou por meio do processo radioativo de emissão de fluorescência. As propriedades fluorescentes dos fármacos fotossensibilizantes são úteis para a visualização, localização e delineação de lesões malignas (RANYUK et al, 2013;YAMADA et al, 2013). Por outro lado, o fármaco fotossensibilizante pode dar origem ao estado excitado tripleto, um estado de energia ligeiramente mais baixa que o estado excitado singleto e com tempo de vida mais longo (s-ms), por meio de conversão de spin eletrônico, no processo chamado cruzamento intersistema (RONZANI et al, 2013).…”

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Estudos fotofísicos e fotobiológicos de sistemas de liberação contendo o fármaco fotossensível cloro-ftalocianina de alumínio para aplicação em terapia fotodinâmica

Silva¹

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Estudos fotofísicos e fotobiológicos de sistemas de liberação contendo o fármaco fotossensível cloro-ftalocianina de alumínio para aplicação em terapia fotodinâmica UNIVERSIDADE DE SÃO PAULO FACULDADE DE CIÊNCIAS FARMACÊUTICAS DE RIBEIRÃO PRETOEstudos fotofísicos e fotobiológicos de sistemas de liberação contendo o fármaco fotossensível cloro-ftalocianina de alumínio para aplicação em terapia fotodinâmica A terapia fotodinâmica (TFD) tem se apresentado nos últimos anos como uma alternativa para o tratamento de tumores cutâneos, viscerais e sistêmicos, demonstrando resultados promissores, tanto em estudos in vitro como in vivo. Trata-se de uma técnica simples e não invasiva. A terapia consiste na excitação de um fármaco fotossensibilizante por uma fonte de luz visível que depois de absorvida pela molécula, leva a produção espécies reativas de oxigênio (EROs) em presença do oxigênio molecular por uma sequencia de reações fotoquímicas. Nesse trabalho propõe-se a preparação, caracterização e detreminação da atividade fotodinâmica de uma nanoemulsão rica em colesterol e de lipossomas ultradeformáveis como novos sistemas formulations demonstrated that the incorporation was able to improve its photophysical characteristics. In in vitro studies, the drug delivery systems showed no cytotoxicity in the absence of light, but demonstrated increased in PcAlCl photodynamic activity up to 80% over the PcAlCl free when irradiated. All formulations showed characteristics, which cooperates with the use of these drug delivery systems for, increased the PcAlCl photodynamic activity for glioblastoma and melanoma treatment.Keywords: Glioblastoma, Melanoma, Liposome, LDE, Photodynamic therapy. 1 1. Introdução Gliomas e a barreira hematoencefálica (BHE)Gliomas malignos estão entre os tipos mais comuns de tumores cerebrais, ocorrendo em 5-7 a cada 100.000 indivíduos por ano (LARJAVAARA et al., 2007;SEHMER et al., 2014 et al., 2016). Esse tipo de patologia é sempre associado a um prognóstico ruim, podendo acometer qualquer parte do tecido cerebral e da medula espinhal, e a uma expectativa de vida muito curta entre 12 e 15 meses (ROBERTS et al., 2011;SCHNEIDER et al., 2016). Como opção mais utilizada de tratamento, adota-se ressecção cirúrgica, seguida por tratamento com radiação e quimioterapia com Temozolamida, que combinadas conferem um período médio de sobrevivência do paciente de até 14,6 meses (STUPP , MASON e VAN DEN BEUF, 2005;ZHANG et al., 2016). Contudo, às células do glioma tem apresentado resistência à radiação e a quimioterapia com base nos protocolos difundidos utilizados frequentemente (JOHANSSON et al., 2010). Além disso, a natureza das células tumorais do GBM e a existência de barreiras fisiológicas, especialmente a barreira hematoencefálica (BHE), o GBM continua sem cura. A falta da capacidade de permeação de fármacos na BHE faz com que o tratamento quimioterápico do glioblastoma seja limitado (LI et al., 2014c).A barreira hematoencefálica (BHE) é uma barreira celular que separa o sangue do tecido cerebral que regula a ...

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Accuracy and validity of sentinel lymph node biopsy for breast cancer using a photosensitizer: 8-year follow-up

Cited by 3 publications

References 20 publications

Recent Studies in Photodynamic Therapy for Cancer Treatment: From Basic Research to Clinical Trials

Recent Studies in Photodynamic Therapy for Cancer Treatment: From Basic Research to Clinical Trials

New Alternative Techniques for Sentinel Lymph Node Biopsy

Estudos fotofísicos e fotobiológicos de sistemas de liberação contendo o fármaco fotossensível cloro-ftalocianina de alumínio para aplicação em terapia fotodinâmica

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