Accuracy, Concordance, and Reproducibility of Histologic Diagnosis in Cutaneous T-Cell Lymphoma&lt;subtitle&gt;An EORTC Cutaneous Lymphoma Project Group Study&lt;/subtitle&gt;

Santucci, Marco; Biggeri, Annibale; Feller, Alfred C.; Burg, Günter

doi:10.1001/archderm.136.4.497

Cited by 60 publications

(32 citation statements)

References 34 publications

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“…34,35 This emphasizes the need for clinicopathologic correlation when interpreting the results of clonality studies. While several authors have suggested evolving histologic criteria for the diagnosis of cutaneous T-cell lymphoma over the past several years, [36][37][38][39] ultimately, clinicopathologic correlation is essential when differentiating MF from its histologic mimickers.…”

Section: Resultsmentioning

confidence: 99%

Histologic mimickers of mycosis fungoides: a review

Reddy

Bhawan

2006

J Cutan Pathol

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Mycosis fungoides (MF) is a rare type of non-Hodgkin's lymphoma affecting the skin. Because MF develops slowly over several years and may have a variety of clinical presentations, including itchy patches, plaques or tumors that may be confused with common benign conditions such as eczema and psoriasis, the disease presents a diagnostic challenge. The average time to diagnosis varies but is frequently as long as 3 to 6 years. Skin biopsies frequently reveal nonspecific features of several dermatoses; thus, histologic evaluation of the disease is also challenging. Importantly, various significant and/or benign conditions may mimic MF histologically and result in a misdiagnosis of MF. Here we review the reported histologic mimickers of MF and discuss both similar and differentiating features of each, in order to aid in more accurate interpretation of diagnostically challenging skin biopsies. Clinicopathologic correlation is ultimately essential to make accurate diagnosis of MF and its histologic mimickers.Reddy K, Bhawan J. Histologic mimickers of mycosis fungoides: a review.

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Section: Resultsmentioning

confidence: 99%

Histologic mimickers of mycosis fungoides: a review

Reddy

Bhawan

2006

J Cutan Pathol

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“…4,[6][7][8][9][10][11] The histopathologic features of early MF vary from person to person, over time, and even between multiple sites in a single patient. 12,13 In addition, Figure 1.…”

Section: Commentmentioning

confidence: 99%

“…4,14 These difficulties are highlighted by reported false-negative and false-positive rates as high as 40%, 15 in addition to low concordance and reproducibility rates. 4,[8][9][10] Because of these diagnostic challenges in early MF, during the past decades, several authors have attempted to identify the most-reliable diagnostic criteria for distinguishing MF from benign dermatoses. 4,5,7,[10][11][12][13][14]16,17 Characteristic histopathologic features of early MF include the presence of enlarged epidermal lymphocytes with cerebriform nuclei within the epidermis and minimal associated spongiosis (epidermotropism), larger lymphocytes in the epidermis than in the dermis, lymphocytes with perinuclear clearing (halo), and a linear arrangement of basilar epidermal lymphocytes along the dermal-epidermal junction (tagging) (Figure 2, B through D).…”

Section: Commentmentioning

confidence: 99%

Selected Inflammatory Imitators of Mycosis Fungoides: Histologic Features and Utility of Ancillary Studies

Arps

Chen

Fullen

et al. 2014

Archives of Pathology &Amp; Laboratory Medicine

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Mycosis fungoides is the most common primary cutaneous lymphoma; however, it remains a significant diagnostic challenge, in part because of the overlap with several inflammatory dermatoses. Despite advances in immunohistochemistry and molecular diagnostics, false-positive, false-negative, and indeterminate diagnoses are not uncommon. In most cases, the overall balance of morphologic, immunophenotypic, and genetic features must be considered carefully because there are few sensitive and specific clues to the diagnosis. Moreover, an appropriate clinical presentation is essential to the diagnosis and helps to favor or exclude inflammatory/reactive processes. Herein, we discuss 3 important inflammatory dermatoses that may closely simulate mycosis fungoides, and we review the use of ancillary studies in these challenging cases.

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“…The two entities represent the same disease presenting in cutaneous plaque or infiltrating form (MF) and disseminated erythroderma form (SSx). Prolonged monitoring may be needed to distinguish these entities from other hyperkeratotic and reactive skin lesions, and diagnostic accuracy in early stages may be as low as 40% [46]. Repeated skin biopsies for cerebriform T-cell infiltration and Pautrier microabscesses and gene rearrangement studies may be necessary [47••].…”

Section: Cutaneous Group Mycosis Fungoides and Sezary Syndromementioning

confidence: 99%

ziPeripheral T-cell lymphoma

Liang

2002

Curr Oncol Rep

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Peripheral (post-thymic) T-cell lymphoma consists of a wide spectrum of disorders with marked differences in biology and behavior. Proper classification is pivotal for evaluating treatment results, and most studies performed a decade ago lump together different disease entities and cannot be interpreted. With improved use of immunophenotyping and molecular methods for these disorders, their exact nature is better defined in the Revised European-American Lymphoma and subsequent World Health Organization (WHO) classifications. The WHO classification of post- thymic T/natural killer (NK)-cell lymphoma consists of 15 entities, including about 30% that are unclassified cases. A wide range in incidence exists between different populations, but it is likely to be lower than previously estimated. Certain entities, like nasal/nasal-type T/NK-cell lymphoma and human T-cell leukemia/lymphoma virus 1, are much more prevalent in certain racial groups and show exquisite viral association. In these entities as a group, prognosis and treatment seem inferior to those of their B-cell counterparts, but treatment must be tailored to the exact pathologic diagnosis and prognostic index. Aggressive combination chemotherapy appears to be curative for certain entities (eg, anaplastic lymphoma kinase-positive), whereas purine analogues may be useful for low-grade entities. The role of autologous and allogeneic stem cell transplantation is still poorly defined. Specific antibody-based therapy is also on the horizon.

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Accuracy, Concordance, and Reproducibility of Histologic Diagnosis in Cutaneous T-Cell Lymphoma<subtitle>An EORTC Cutaneous Lymphoma Project Group Study</subtitle>

Cited by 60 publications

References 34 publications

Histologic mimickers of mycosis fungoides: a review

Histologic mimickers of mycosis fungoides: a review

Selected Inflammatory Imitators of Mycosis Fungoides: Histologic Features and Utility of Ancillary Studies

ziPeripheral T-cell lymphoma

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