Accuracy improvement of determination of seven minor tobacco alkaloids in mainstream cigarette smoke using analyte protectants by gas chromatography-mass spectrometry

Guo, Qiong; Qin, Yuling; Pan, Lining; Xie, Fuwei; Liu, Shaofeng; Sun, Xuehui; Wang, Xiaoyu; Cai, Junlan; Zhao, Xiaodong; Liu, Huimin

doi:10.1016/j.chroma.2022.463537

Cited by 2 publications

(1 citation statement)

References 28 publications

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“…Mainstream cigarette smoke (MCS) is an extremely complex aerosol composed of condensed liquid droplets (particulate phase) and a mixture of gases and volatile compounds (gaseous phase). Thousands of chemicals, including ketones, hydrocarbons, ethers, amides, carboxylic acids, alkaloids, and phenols, most of which are at trace level, have been identified in tobacco smoke [13][14][15]. In-depth characterization of the chemical composition of MCS is important for evaluating its impact on human health and developing strategies to reduce its harmful effects.…”

Section: Introductionmentioning

confidence: 99%

A Comprehensive Study on the Acidic Compounds in Gas and Particle Phases of Mainstream Cigarette Smoke

Lu,

Zhang,

Cao

et al. 2023

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Acidic compounds constitute a group of chemicals present in mainstream cigarette smoke, among which organic acids contribute to flavoring. In order to obtain a comprehensive understanding of the constituents of acidic compounds in both the particulate and gaseous phases of the mainstream smoke of commercial cigarettes, and to delineate the difference between two types of cigarettes, the yields of acidic constituents from nine cigarettes of two commercial brands (L- and M-types) were collected and analyzed in detail by gas chromatography–mass spectrometry (GC-MS). The results identified and quantitatively analyzed 46 compounds, grouped according to the substituent groups. Compositional differences between the two cigarette types were evaluated with statistical approaches. Comparison between individual, grouped, and total acid contents, between the particulate and the gaseous phases, and between the commercial L- and M-type tobaccos were conducted and characterized by the p values obtained from Student’s t-test. Multivariate analysis was performed using principal component analysis (PCA) and orthogonal projections to latent structures discriminant analysis (OPLS-DA) models to identify the acids that enable a reliable differentiation of the two types. Seventeen acidic compounds whose p < 0.05 and variable importance in projection (VIP) > 1 were identified as key components that could discriminate between the two groups of commercial cigarettes. This study may be beneficial for the development of non-combusted tobacco products, which could serve as alternatives to traditional cigarettes.

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Section: Introductionmentioning

confidence: 99%

A Comprehensive Study on the Acidic Compounds in Gas and Particle Phases of Mainstream Cigarette Smoke

Lu,

Zhang,

Cao

et al. 2023

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Enantiomeric separation of four pairs of alkaloids by using a C18 column tandem polysaccharide-based chiral column

Si,

Tian,

et al. 2024

Reviews in Analytical Chemistry

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Alkaloid enantiomers have different physiological and pharmacological effects, and different chiral compositions have a large impact on cigarette sensory and use safety. Studying the effects of different configurations of alkaloid enantiomers on cigarette sensory is important for the development of tobacco products, but the chiral separation of alkaloid enantiomers has become the core problem. Here, the application of a C18 column coupled with a polysaccharide-based chiral column to separate and detect four pairs of alkaloid enantiomers in tobacco and cigarette smoke of different brands was investigated. Results showed that the tandem technology of the two columns enabled the baseline separation of four pairs of alkaloid enantiomers. The resolution of enantiomers of alkaloids in different tobacco samples differed in content and ratio, showing different chiral distribution characteristics. According to the different distribution characteristics of alkaloid enantiomers, tobacco samples of different brands can be distinguished and real cigarettes can be identified.

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Accuracy improvement of determination of seven minor tobacco alkaloids in mainstream cigarette smoke using analyte protectants by gas chromatography-mass spectrometry

Cited by 2 publications

References 28 publications

A Comprehensive Study on the Acidic Compounds in Gas and Particle Phases of Mainstream Cigarette Smoke

A Comprehensive Study on the Acidic Compounds in Gas and Particle Phases of Mainstream Cigarette Smoke

Enantiomeric separation of four pairs of alkaloids by using a C18 column tandem polysaccharide-based chiral column

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