Accuracy of 18F‐FDG‐PET/CT for staging of oral squamous cell carcinoma

Pentenero, Monica; Cistaro, Angelina; Brusa, MSci Mario; Ferraris, M.; Pezzuto, Carla; Carnino, Riccardo; Colombini, E; Valentini, Maria Consuelo; Giovanella, Luca; Spriano, Giuseppe; Gandolfo, S

doi:10.1002/hed.20906

Cited by 53 publications

(34 citation statements)

References 24 publications

(26 reference statements)

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“…Furthermore, as we previously reported (24), in 3 patients 18 F-FDG PET/CT was able to correctly exclude deep-bone involvement detected by CT and MRI, reducing the stage from T4 to T2. In these patients, when comparing the openand closed-mouth scans, we observed that the open-mouth scan allowed an easier restaging of the tumor.…”

Section: Discussionsupporting

confidence: 59%

Assessment of a New 18F-FDG PET/CT Protocol in the Staging of Oral Cavity Carcinomas

Cistaro¹,

Palandri²,

Balsamo³

et al. 2011

Journal of Nuclear Medicine Technology

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Because image fusion using 18 F-FDG PET/CT allows a better localization of the pathologic uptake, this modality has a greater sensitivity than PET alone in examining the head-neck region. However, examination of this area is particularly critical because the head and neck are close to other anatomic structures and because of the high physiologic uptake of the radiocompound. The purpose of this study was to evaluate the utility of a new imaging protocol in the staging of oral carcinoma. Methods: Thirty-four consecutive patients (21 women and 13 men; age range, 20-84 y) with untreated biopsy-proven oral squamous cell carcinomas were examined using whole-body 18 F-FDG PET/CT fusion imaging. All patients observed strict regulations before undergoing the PET/CT examination. At the end of the whole-body acquisition, another open-mouth scan was obtained. To compare the open-and closed-mouth methods, we analyzed features such as the feasibility of an accurate topographic localization of the tumor, evaluation of tumor extent, detection of tumor involvement with adjacent structures, and involvement of lymph nodes to which we assigned a score from 1 to 5. Results: No cases of 18 F-FDG physiologic uptake in the tongue or muscles were observed. The open-mouth scan obtained a better score than did the closed-mouth scan when considering the tumor localization, tumor extent, and evaluation of adjacent anatomic structures near the clinically evident tumor. For lymph node involvement, the 2 methods showed similar results. Conclusion:The open-mouth scan improved the anatomic tumor localization and extent and detection of tumor involvement in adjacent anatomic structures achieved by the standard PET/CT procedure. In addition, time of the examination (mid morning), relaxation of muscles before the compound was administered, and an upright position while the patient waited caused a reduction of the frequent equivocal physiologic uptake in the head and neck region. The open-mouth method does not influence the nodal staging.

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Section: Discussionsupporting

confidence: 59%

Assessment of a New 18F-FDG PET/CT Protocol in the Staging of Oral Cavity Carcinomas

Cistaro¹,

Palandri²,

Balsamo³

et al. 2011

Journal of Nuclear Medicine Technology

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“…Before starting treatment, a key point in diagnosis is to evaluate the presence and extent of tumour invasion into bone. At present, preoperative assessments usually consist of clinical examination, conventional radiography by orthopantomogram (OPG) and periapical radiographs, and if available, computerised tomography (CT), radionuclide bone scanning and magnetic resonance imaging [72]. Other more sophisticated diagnostic tools such as multi-detector row CT or positron emission tomography/CT (PET/CT) have been shown to have a higher sensitivity in the assessment of bone invasion, but are not in routine use in most institutions [73,74].…”

Section: Discussionmentioning

confidence: 99%

Potential molecular targets for inhibiting bone invasion by oral squamous cell carcinoma: a review of mechanisms

Quan

Johnson

Zhou

et al. 2011

Cancer Metastasis Rev

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Bone invasion is a common characteristic of oral squamous cell carcinoma (OSCC), with adverse affects on patient functionality and survival. Recent studies suggest that it is osteoclasts, rather than malignant keratinocytes themselves, which play the major role in facilitating the entry of the tumour into bone, and its progression within bone. Osteoclasts respond to a variety of local signalling pathways, initiated by products of the malignant epithelial cells. In the present review, we firstly introduce the clinical patterns of bone invasion, and then summarise these signalling pathways and their diverse roles in sequential phases of bone invasion. We also review current researches regarding the incidence and mechanisms of distant metastases to bone, and explain briefly the concept of epithelial-mesenchymal transition, which may generate cancer stem cells and initiate the bone invasion. Finally, we discuss more briefly approaches to the diagnosis and management of OSCC patients with bone invasion. With all these studies and some recent discoveries in our own laboratory, an enhanced understanding of bone invasion will be achieved, which should indicate potential molecular targets for future biotherapies.

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“…The use of integrated PET/CECT could have several advantages. In most PET/CT studies, the CT scan portion is a non-optimized head and neck CT and a separate dedicated and fully optimized head and neck CT scan was performed 7,9,23,25 . In this setting PET/CT can cause logistic problems and is time consuming for patient and clinician because of the need to perform an extra imaging modality.…”

Section: Discussionmentioning

confidence: 99%

Performance of 18F-FDG PET/contrast-enhanced CT in the staging of squamous cell carcinoma of the oral cavity and oropharynx

Krabbe

Balink

Roodenburg

et al. 2011

International Journal of Oral and Maxillofacial Surgery

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Accuracy of 18F‐FDG‐PET/CT for staging of oral squamous cell carcinoma

Abstract: PET/CT scan showed good accuracy in determining the extension and/or depth of invasion of the primary tumor. Nevertheless, PET/CT was not accurate to rule out nodal metastases.

Cited by 53 publications

References 24 publications

Assessment of a New 18F-FDG PET/CT Protocol in the Staging of Oral Cavity Carcinomas

Assessment of a New 18F-FDG PET/CT Protocol in the Staging of Oral Cavity Carcinomas

Potential molecular targets for inhibiting bone invasion by oral squamous cell carcinoma: a review of mechanisms

Performance of 18F-FDG PET/contrast-enhanced CT in the staging of squamous cell carcinoma of the oral cavity and oropharynx

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