Accuracy of a Flash Glucose Monitoring System in Diabetic Dogs

Abstract

BackgroundA novel flash glucose monitoring system (FGMS) (FreeStyle Libre, Abbott, UK) was recently developed for humans. It continuously measures the interstitial glucose (IG) concentrations for 14 days.ObjectivesTo assess the clinical and analytical accuracy of the FGMS in diabetic dogs.AnimalsTen client‐owned diabetic dogs on insulin treatment.MethodsProspective and observational study. The FGMS was placed on the neck for up to 14 days. During the 1st–2nd, 6–7th, and 13–14th days from application, the IG measurements were compared with the plasma (EDTA) glucose (PG) concentrations analyzed by a reference hexokinase based method.ResultsThe application and the use of the FGMS were apparently painless, easy, and well tolerated by all dogs. Mild erythema at the site of the application was found in 5/10 dogs at the end of the wearing period. A good correlation between IG and PG concentrations (rho = 0.94; P < .001) was found. The FGMS was 93, 99, and 99% accurate at low, normal, and high blood glucose concentrations. Mean ± standard deviation difference from the reference method was 2.3 ± 46.8 mg/dL.Conclusion and clinical importanceThe FGMS is easy to use and is accurate for IG glucose measurement in diabetic dogs.

Diabetes mellitus in dogs

“…For example, an animal suffering a hypoglycaemic episode may have persistent hyperglycaemic response for several hours due to the release of endogenous antagonistic hormones such as glucagon, adrenaline and cortisol. In recent years, continuous glucose monitors, which use a disposable sensor (Fig 8) to measure interstitial fluid glucose over a period of several days, have also been used with some success in veterinary patients (Davison and others 2003b, Corradini and others 2016). Where available, these may be appropriate to consider in patients where repeated venepuncture or capillary sampling is not practical.…”

“…Blood glucose curve: evaluate the response to insulin therapy and rule out inadequate duration of insulin therapy with or without continuous glucose monitoring where available (Corradini and others 2016). …”

Comparison of continuous and intermittent glucose monitoring systems in a dog with diabetic ketoacidosis: a case report

“…Certainly, repeated venipuncture in hospitalised animal patients can cause pain and stress for the animal. Assessing the blood glucose A continuous glucose monitoring system (CGMS) is a monitoring device that evaluates glucose levels from a flexible sensor electrode every five minutes, and allows real-time recording of changes in glucose levels, continuously on a separate screen, for up to 72 h. The CGMS measures the change in interstitial glucose levels, which closely mimic blood glucose levels (Wiedmeyer and DeClue 2008;Surman and Fleeman 2013;Corradini 2016). The CGMS can detect and alert clinicians to short-term variations, such as hypoglycaemia, hyperglycaemia, and the Somogyi phenomenon, that may not be detected between two measurements of traditional glucose monitoring.…”

<b>Utilização do aparelho FreeStyle Libre para monitoração contínua da glicemia em equinos</b>

“…A mais nova geração desses aparelhos mensura imediatamente os valores, permitindo a intervenção em tempo real. No entanto, a principal deficiência da maior parte deles é que precisam ser calibrados e, portanto, é necessária uma amostragem de sangue capilar periodicamente (CORRADINI et al, 2016).…”

“…As mensurações de glicose intersticial são mensuradas a cada minuto através de sensor descartável, medindo 3,5 centímetro, com cateter de 0,5 centímetro, inserido sob a pele, podendo ser usado por até 14 dias. Ele é calibrado de fábrica e não requer amostra de sangue para calibragem (CORRADINI et al, 2016…”