Accuracy of an oscillometric blood pressure monitor in anesthetized pigs

Reed, Rachel; Barletta, Michele; Grimes, J. M.; Mumaw, Jennifer; Park, Hea Jin; Giguère, Steeve; Azain, M. J.; Fang, Xi; Quandt, Jane

doi:10.1177/0023677218763686

Cited by 6 publications

(3 citation statements)

References 29 publications

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“…Arterial cannulation allows invasive blood pressure measurement, which is considered the gold standard of blood pressure monitoring in pigs. 16,17 Oscillometry may have resulted in underestimation of the blood pressure, 17,18 but there is conflicting literature regarding the accuracy of NIBP monitoring in pigs. 16,19,20 Despite this, trend analysis is still possible.…”

Section: Discussionmentioning

confidence: 99%

“…In the authors’ experience, arterial cannulation can be more challenging when the blood pressure is low and arterial pulsations are more difficult to palpate, as suspected in this case. Arterial cannulation allows invasive blood pressure measurement, which is considered the gold standard of blood pressure monitoring in pigs 16,17 . Oscillometry may have resulted in underestimation of the blood pressure, 17,18 but there is conflicting literature regarding the accuracy of NIBP monitoring in pigs 16,19,20 .…”

Section: Discussionmentioning

confidence: 99%

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Anaesthesia, analgesia and cardiovascular support in a Kunekune pig undergoing a complicated umbilical hernia repair

Dagnall¹,

Deutsch²

2023

Vet Record Case Reports

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This report describes the peri‐operative anaesthesia and analgesia management of a 5‐year‐old Kunekune pig undergoing surgical correction of an umbilical hernia. Premedication with azaperone (1 mg/kg), xylazine (0.5 mg/kg), butorphanol (0.2 mg/kg) and ketamine (5 mg/kg) intramuscularly preceded induction of anaesthesia with ketamine (2 mg/kg) intravenously. General anaesthesia was maintained with isoflurane in 100% oxygen. Analgesia was supported intraoperatively by a transversus abominis plane block with lidocaine (1.5 mg/kg), and a ketamine (10 μg/kg/min) infusion intravenously. Crystalloid fluid boluses and atropine intravenously were administered, and mechanical ventilation was stopped to aid correction of hypotension. Post‐operative analgesia was supported with a continuous infusion of ketamine (5 μg/kg/min) intravenously, butorphanol (0.2 mg/kg) intravenously every 6 hours, paracetamol (10 mg/kg) intravenously orally every 8 hours and meloxicam (0.4 mg/kg) intravenously orally every 24 hours. The pig made progressive clinical improvement and was discharged 7 days after the surgery.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Anaesthesia, analgesia and cardiovascular support in a Kunekune pig undergoing a complicated umbilical hernia repair

Dagnall¹,

Deutsch²

2023

Vet Record Case Reports

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show abstract

“…Modelling some aspects of diagnosis and treatment of ACS using a porcine hind limb has proven especially useful given their similar anatomy, size better suited for human instrumentation, and similar blood pressure-a physiological parameter vital in compartment syndrome. 2,24,25 Xanthos et al 26 studied baseline hemodynamics such as blood pressure in swine and found relatively similar values to those of humans, which is important when assessing perfusion pressure. Delta P or perfusion pressure values of relevance to pig physiology have yet to be determined.…”

Section: Introductionmentioning

confidence: 99%

Porcine Model of Acute Compartment Syndrome

Honjol

Monk

Schupbach

et al. 2023

Journal of Orthopaedic Trauma

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Objectives:Acute compartment syndrome is a devastating condition associated with lasting consequences or even death if not treated in a timely fashion. Current preclinical modeling is inadequate. Ideally a model should mimic human disease. There should be a trauma-induced reperfusion or direct muscle event that causes gradual increased pressure and is amenable to release with fasciotomy. We have attempted to reproduce this mechanism and outcome in a porcine model.Methods:Anterior tibial musculature was injured with vascular occlusion plus exterior tourniquet crush or direct intracompartmental crush through balloon inflation. The injury was maintained for over 5 hours. At that time, the tourniquet or balloon was removed. The injuries were continuously monitored with an intramuscular continuous pressure sensor. Pressure changes were recorded and after 2 hours of postinjury observation, a fasciotomy was performed for the muscle compartment.Results:Pressures were brought to 100 mm Hg during the injury phase. During the two-hour observation period, the balloon catheter technique achieved an average pressure of 25.1 ± SD 8.8 mm Hg with a maximum reading of 38.2 mm Hg and minimum reading of 14.1 mm Hg. During this same period, the ischemia-reperfusion + direct crush technique achieved an average pressure of 33.7 ± SD 7.3 mm Hg, with a maximum reading of 43.5 mm Hg and minimum reading of 23.5 mm Hg. Average pressure postfasciotomy for the balloon catheter technique was 2.4 ± SD 2.5 mm Hg; and for the crush technique, average value postfasciotomy was 4.9 ± SD 3.7 mm Hg—both representing a return to physiologic levels.Conclusion:This is the first preclinical model that shows the same response to injury and treatment as is observed in human physiology. Surgical and nonsurgical therapies for compartment syndrome can now be tested reliably.

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Assessment of hemodynamic and blood parameters that may reflect macroscopic quality of porcine kidneys during normothermic machine perfusion using whole blood

Steinhauser,

Yakac,

Markgraf

et al. 2024

World J Urol

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Purpose Using ex vivo normothermic machine perfusion (NMP) with whole blood we assessed marginal porcine kidneys under reperfusion. The aim was to link measureable machine and clinical blood parameters with the currently used visual assessment. This could serve as a baseline for a standardized evaluation score to identify potentially transplantable kidneys in the future. Methods Kidneys and autologous whole blood were procured from slaughterhouse pigs (n = 33) and were perfused for 4 h using NMP. The hemodynamic parameters arterial pressure (AP), renal blood flow (RBF) and intrarenal resistance (IRR) were measured. Activity of aspartate transaminase (AST), gamma-glutamyltransferase (GGT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and lactate were assessed in blood at 0/1/2/4 h. Kidneys were grouped into “potentially transplantable” (PT) or “not transplantable” (NT) based on their overall macroscopic appearance after NMP by an experienced physician. Results PT-kidneys (n = 20) had a significantly lower IRR and higher RBF than NT-kidneys (n = 13). GGT, ALP and LDH did not differ significantly, but at 4 h, AST was significantly higher in PT-kidneys compared to NT-kidneys. Lactate levels kept increasing during NMP in NT-kidneys and were significantly higher at 1/2/4 h than in PT-kidneys. Conclusion The immediately assessed macroscopic aspects of examined kidneys correlated with hemodynamic parameters, increased lactate and lower AST in this study. In the future, NMP with whole blood could be a useful tool to extend the donor pool by allowing the assessment of otherwise unknown characteristics of marginal kidneys before transplantation.

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Accuracy of an oscillometric blood pressure monitor in anesthetized pigs

Cited by 6 publications

References 29 publications

Anaesthesia, analgesia and cardiovascular support in a Kunekune pig undergoing a complicated umbilical hernia repair

Anaesthesia, analgesia and cardiovascular support in a Kunekune pig undergoing a complicated umbilical hernia repair

Porcine Model of Acute Compartment Syndrome

Assessment of hemodynamic and blood parameters that may reflect macroscopic quality of porcine kidneys during normothermic machine perfusion using whole blood

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