Accuracy of carboxyhe-moglobin dilution method for the measurement of circulating blood volume

Ohki, Satoshi T.; Kunimoto, Fumio; Isa, Yukitaka; Obata, Hideaki; Ishikawa, Susumu; Koyano, Tetsuya; Oriuchi, Noboru; Goto, Fumio; Morishita, Yasuo

doi:10.1007/bf03018851

Cited by 16 publications

(17 citation statements)

References 13 publications

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“…Commonly used techniques for determination of blood volume are radioactive indicators, dye-dilution methods or carbon monoxide labelling of haemoglobin (Hb) following carbon monoxide rebreathing (Ertl et al 2007). Carbon monoxide rebreathing has been shown to have similar accuracy, sensitivity and variability as the gold standard radioactive methods (Burge and Skinner 1995; Ohki et al 2000). The accuracy of the carbon monoxide rebreathing method stands on the reliability and precision in measuring changes in carboxyhaemoglobin (COHb) saturation (Gore et al 2005).…”

Section: Introductionmentioning

confidence: 99%

Determination of blood volume by pulse CO-oximetry

et al. 2011

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Aim The objective of this study was to determine whether changes in carboxyhaemoglobin (COHb) saturation following carbon monoxide (CO) rebreathing can be accurately detected by Pulse CO-Oximetry in order to determine blood volume. Methods Noninvasive measurements of carboxyhaemoglobin saturation (SpCO) were continuously monitored by Pulse CO-Oximetry before, during and following 2 minutes of CO rebreathing. Reproducibility and accuracy of noninvasive blood volume measurements were determined in 16 healthy non-smoking individuals (15 males, age: 28 ± 2 years, body mass index: 25.4 ± 0.6 kg/m2) through comparison with blood volume measurements calculated from invasive measurements of COHb saturation. Results The coefficient of variation for noninvasive blood volume measurements performed on separate days was 15.1% which decreases to 9.1% when measurements were performed on the same day. Changes in COHb saturation and SpCO following CO rebreathing were strongly correlated (r=0.90, p<0.01), resulting in a significant correlation between invasive and noninvasive blood volume measurements (r=0.83, p=0.02). Conclusion Changes in SpCO following CO rebreathing can be accurately detected by Pulse CO-Oximetry, which could potentially provide a simplified, convenient and reproducible method to rapidly determine blood volume in healthy individuals.

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Section: Introductionmentioning

confidence: 99%

Determination of blood volume by pulse CO-oximetry

et al. 2011

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“…Recently, the carbon monoxide (CO) rebreathing method has been improved several times (Thomsen et al 1991;Burge and Skinner 1995;H€ utler et al 2000;Schmidt and Prommer 2005;Gore et al 2006;Siebenmann et al 2017), and the application of this method has been reported in many studies. The accuracy of the CO dilution method has been shown to be similar to that of the 51 CR method (Fukui and Shigemi 1989;Ohki et al 2000). CO binds almost completely to hemoglobin.…”

Section: Introductionmentioning

confidence: 72%

“…The accuracy of the CO dilution method has been shown to be similar to that of the 51 CR method (Fukui and Shigemi ; Ohki et al. ). CO binds almost completely to hemoglobin.…”

Section: Introductionmentioning

confidence: 84%

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Determination of hemoglobin mass in humans by measurement of CO uptake during inhalation of a CO-air mixture: a proof of concept study

Falz

Busse

2018

Physiol Rep

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Measuring hemoglobin mass (Hbmass) using the carbon monoxide (CO) bolus rebreathing method is frequently used in research but has yet to be widely used in the clinical practice. The estimation of an adequate CO bolus may be difficult in patients with unknown Hbmass. In the present pilot study, a progressive inhalation technique for CO that leads to a linear individual adjusted COHb increase was evaluated. Sixteen healthy test subjects participated in the study (preliminary investigation: six; main study: ten). The reliability and validity of the new method were evaluated using multiple measurements of Hbmass with and without a defined blood donation and compared to a CO bolus method. The participants inhaled a CO‐air mixture (CO concentration: 1500 ppm) for a specific breathing duration. The CO uptake and COHb change were determined simultaneously. The typical error (reliability) in the repeated measurements was 2.4% (CI ± 4.7). The mean difference between the new method and the bolus method was 34 g (±41; P = 0.026). The measured hemoglobin loss in 490 mL of blood was 74 g (±35), and the calculated hemoglobin loss was 77 g (±4) (mean difference 3 g ± 34; P = 0.820). The new method was reliable and valid in a proof of concept study with healthy subjects. The total amount of CO and as a result the COHb increase is individually adjustable. Future studies in clinical settings are needed to determine if the method could be used in disease‐specific pathologies associated with changes in Hbmass.

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“…17 In that paper, we simultaneously measured BVc using the 51 Cr method as well as the CO method and verified the accuracy and precision of the CO method by comparing the values obtained from the CO method with those from the 5 1 Cr method which is widely accepted as a standard method for BVc measurement. Small mean differences and standard deviations between the CO method and the 5 1 Cr method (-70.2 ± 184.8 ml) and small percentage errors (-0.49 ± 1.29%) indicated the accuracy and precision of the CO method, and a close correlation was observed (r=0.97).…”

Section: Measurement Of Bvc the Co Methodsmentioning

confidence: 84%

Changes in gastric intramucosal pH and circulating blood volume following coronary artery bypass grafting

Ohki

Kunimoto

Isa

et al. 2000

Can J Anesth/J Can Anesth

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Purpose: To determine the changes in gastric intramucosal pH (pHi) following coronary artery bypass grafting (CABG) in comparison with systemic hemodynamic variables and circulating blood volume (BVc).Methods: Twenty patients who underwent CABG under mild hypothermic cardiopulmonary bypass (CPB) were included. Hemodynamic variables and the values of pHi were obtained at 3,6,12 and 24 hr after admission to the intensive care unit (ICU). The pHi was measured by gastric tonometric catheter. The BVc was measured by carbon monoxide (CO)-labeled hemoglobin (CO-Hb) dilution method (CO method) at 6 and 24 hr after ICU admission.Results: Systemic vascular resistance index (SVRI) and pulmonary vascular resistance index (PVRI) decreased with time. Systemic oxygen delivery index (DO 2 I) and systemic oxygen consumption index (VO 2 I) showed a gradual increase during the study period. By contrast, pHi decreased to the lowest value (7.26 ± 0.05) at six hours and returned to normal levels (7.34 ± 0.04) at 24 hr after ICU admission. Changes in BVc between six and 24 hr ranged from -242 ml to 978 ml (mean, 334 ± 338 ml). The pHi increased in patients whose BVc increased by > 300 ml. Mean fluid balance was negative in this period (-386 ± 667 ml; range, -1786 -+ 423 ml). Conclusion:The pHi showed the lowest value at six hours and returned to normal at 24 hr after ICU admission. The pHi increased with the decrease in vascular resistance and with the increases in BVc in this period. The improvement of pHi, an indicator of splanchnic perfusion, appears to be related to systemic vasodilatation and an increase in BVc.

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Accuracy of carboxyhe-moglobin dilution method for the measurement of circulating blood volume

Abstract: The CO method can measure BVc with a similar degree of accuracy as the 51Cr method. It is simple, repeatable and safe without the risk of exposure to radioactivity in the ICU.

Cited by 16 publications

References 13 publications

Determination of blood volume by pulse CO-oximetry

Determination of blood volume by pulse CO-oximetry

Determination of hemoglobin mass in humans by measurement of CO uptake during inhalation of a CO-air mixture: a proof of concept study

Changes in gastric intramucosal pH and circulating blood volume following coronary artery bypass grafting

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