Accuracy of clinical criteria for AD in the Honolulu–Asia Aging Study, a population-based study

Petrovitch, Helen; White, Lon R.; Ross, G. Webster; Steinhorn, Sandra C.; Li, C. Y.; Masaki, Kamal; Davis, Daron G.; Nelson, James S.; Hardman, John; Curb, J. David; Blanchette, Patricia L.; Launer, Lenore J.; Yano, Katsuhiko; Markesbery, William R.

doi:10.1212/wnl.57.2.226

Cited by 126 publications

(82 citation statements)

References 51 publications

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“…Neuropathologic methods in the population-based Honolulu Asia Aging Study (HAAS) have been detailed elsewhere [34]. Briefly, 8-micron tissue sections from multiple brain regions were analyzed with several stains.…”

Section: Neuropathologymentioning

confidence: 99%

Zinc and copper modulate Alzheimer Aβ levels in human cerebrospinal fluid

Strozyk

Launer

Adlard

et al. 2009

Neurobiology of Aging

137

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Abnormal interaction of β-amyloid 42 (Aβ42) with copper, zinc and iron induce peptide aggregation and oxidation in Alzheimer's disease (AD). However, in health, Aβ degradation is mediated by extracellular metalloproteinases, neprilysin, insulin degrading enzyme (IDE) and matrix metalloproteinases. We investigated the relationship between levels of Aβ and biological metals in CSF. We assayed CSF copper, zinc, other metals and Aβ42 in ventricular autopsy samples of Japanese American men (N= 131) from the population-based Honolulu-Asia Aging Study. There was a significant inverse correlation of CSF Aβ42 with copper, zinc, iron, manganese and chromium. The association was particularly strong in the subgroup with high levels of both zinc and copper. Selenium and aluminum levels were not associated to CSF Aβ42. In vitro, the degradation of synthetic Aβ substrate added to CSF was markedly accelerated by low levels (2 μM) of exogenous zinc and copper. While excessive interaction with copper and zinc may induce neocortical Aβ precipitation in AD, soluble Aβ degradation is normally promoted by physiological copper and zinc concentrations.

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Section: Neuropathologymentioning

confidence: 99%

Zinc and copper modulate Alzheimer Aβ levels in human cerebrospinal fluid

Strozyk

Launer

Adlard

et al. 2009

Neurobiology of Aging

137

View full text Add to dashboard Cite

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“…Autopsy substudy. Baseline characteristics of the autopsy group were comparable to those of the whole cohort, except the autopsied sample was older and by design included a higher percentage of individuals clinically demented before death (data not shown) (24). A detailed description of neuropathological methods and clinical pathological correlations has been published (26).…”

mentioning

confidence: 96%

“…Dementia caused by other medical conditions included: Parkinson's disease (n ϭ 10), dementia with Lewy bodies (DLB; n ϭ 5), Pick's disease, head trauma, B 12 deficiency, hypothyroidism, progressive supranuclear palsy, and other unknown causes (total number of subjects ϭ 13). Clinical diagnosis of DLB was based on the guidelines from the consortium on DLB (23,24).…”

mentioning

confidence: 99%

“…Among all the VsD cases, 68% had neuropathological evidence of atherosclerosis and did not have substantial AD-related pathologies. Lewy bodies (LBs) in the cortical area were found in ϳ10% of the autopsy group; however, there was only one autopsied case diagnosed with VsD with cortical LB, and there were no diagnosed AD cases with cortical LB (24). Autopsy substudy.…”

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confidence: 99%

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Type 2 Diabetes, APOE Gene, and the Risk for Dementia and Related Pathologies

2002

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Type 2 diabetes may be a risk factor for dementia, but the associated pathological mechanisms remains unclear. We evaluated the association of diabetes alone or combined with the apolipoprotein E (APOE) gene with incident dementia and neuropathological outcomes in a population-based cohort of 2,574 Japanese-American men enrolled in the Honolulu-Asia Aging Study, including 216 subjects who underwent autopsy. Type 2 diabetes was ascertained by interview and direct glucose testing. Dementia was assessed in 1991 and 1994 by clinical examination and magnetic resonance imaging and was diagnosed according to international guidelines. Logistic regression was used to assess the RR of developing dementia, and log-linear regression was used to estimate the incident rate ratio (

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“…[36,45] Brains were fixed by immersion in 10% buffered formalin for at least 10 days after removal. One pathologist identified large and small (lacunar) infarcts by gross examination of coronal sections of the cerebrum and serial sections of the brainstem and cerebellum.…”

Section: Neuropathologic Assessmentmentioning

confidence: 99%

Characterization of Japanese-American men with a single neocortical AD lesion type

Petrovitch

Ross

et al. 2008

Neurobiology of Aging

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Neocortical neuritic plaques (NP) and neurofibrillary tangles (NFT) are hallmarks of Alzheimer's disease (AD) and usually, both are present. The Honolulu-Asia Aging Study autopsy series includes a significant number of individuals with only one neocortical AD lesion type. These could represent an early phase of the AD process. If so, such individuals would be expected to share other clinical and pathological features of AD. We compared frequency of apolipoprotein epsilon E4 (APOE4) allele, average Braak stage, and burden of cerebral amyloid angiopathy (CAA) among the two single lesion type groups, a group without AD lesions, and groups with high and low frequencies of both AD lesions. Single AD lesion groups shared only the characteristics associated with their unique lesion type with the combined AD lesion group and did not have higher prevalence of dementia than the no AD lesion group. Only the NP+NFT group showed a "dose response" relationship with greater probability of dementia with higher neocortical frequencies of either AD lesion. The single neocortical AD lesion groups do not appear to represent early AD.

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Accuracy of clinical criteria for AD in the Honolulu–Asia Aging Study, a population-based study

Cited by 126 publications

References 51 publications

Zinc and copper modulate Alzheimer Aβ levels in human cerebrospinal fluid

Zinc and copper modulate Alzheimer Aβ levels in human cerebrospinal fluid

Type 2 Diabetes, APOE Gene, and the Risk for Dementia and Related Pathologies

Characterization of Japanese-American men with a single neocortical AD lesion type

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