Accuracy of different oxygenation indices in estimating intrapulmonary shunting at increasing infusion rates of dobutamine in horses under general anaesthesia

Briganti, Angela; Portela, Diego A.; Grasso, Salvatore; Sgorbini, Micaela; Tayari, Hamaseh; Bassini, J.R. Fusar; Vitale, Valentina; Romano, Mario; Crovace, Antonio; Breghi, Gloria; Staffieri, Francesco

doi:10.1016/j.tvjl.2015.04.002

Cited by 27 publications

(39 citation statements)

References 23 publications

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“…In a study using sheep, the F‐shunt was shown to be a more accurate estimate of Qs/Qt compared with OTIs . In horses during general anaesthesia, the correlation between the F‐shunt and Qs/Qt was found to be greater than the F‐shunt and OTIs . When used for repeat calculations of venous admixture in a patient, fluctuations in cardiac output and haemoglobin concentration may decrease the reliability of Qs/Qt and F‐shunt results.…”

Section: Discussionsupporting

confidence: 92%

Effect of reducing inspired oxygen concentration on oxygenation parameters during general anaesthesia in horses in lateral or dorsal recumbency

et al. 2017

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Objective To compare the effects of two concentrations of oxygen delivered to the anaesthetic breathing circuit on oxygenation in mechanically ventilated horses anaesthetised with isoflurane and positioned in dorsal or lateral recumbency.Methods Selected respiratory parameters and blood lactate were measured and oxygenation indices calculated, before and during general anaesthesia, in 24 laterally or dorsally recumbent horses. Horses were randomly assigned to receive 100% or 60% oxygen during anaesthesia. All horses were anaesthetised using the same protocol and intermittent positive pressure ventilation (IPPV) was commenced immediately following anaesthetic induction and endotracheal intubation. Arterial blood gas analysis was performed and oxygenation indices calculated before premedication, immediately after induction, at 10 and 45 min after the commencement of mechanical ventilation, and in recovery.Results During anaesthesia, the arterial partial pressure of oxygen was adequate in all horses, regardless of position of recumbency or the concentration of oxygen provided. At 10 and 45 min after commencing IPPV, the arterial partial pressure of oxygen was lower in horses in dorsal recumbency compared with those in lateral recumbency, irrespective of the concentration of oxygen supplied. Based on oxygenation indices, pulmonary function during general anaesthesia in horses placed in dorsal recumbency was more compromised than in horses in lateral recumbency, irrespective of the concentration of oxygen provided.Conclusion During general anaesthesia, using oxygen at a concentration of 60% instead of 100% maintains adequate arterial oxygenation in horses in dorsal or lateral recumbency. However, it will not reduce pulmonary function abnormalities induced by anaesthesia and recumbency.

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Section: Discussionsupporting

confidence: 92%

Effect of reducing inspired oxygen concentration on oxygenation parameters during general anaesthesia in horses in lateral or dorsal recumbency

et al. 2017

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“…The oxygen content-based parameter FSHUNTe has been reported to be more reliable as it takes account for SaO 2 (Araos et al 2012). This index had the best correlation to actual venous admixture in sheep over a large range of FIO 2 (Araos et al 2012), as well as in horses (Briganti et al 2015). Still, its use requires several assumptions like a constant oxygen carrying capacity for hemoglobin estimated in the present study at 3.5 mg/dL, as well as an estimated value for pulmonary end-capillary partial pressure and saturation of oxygen.…”

Section: Discussionmentioning

confidence: 99%

Impact of low inspired oxygen fraction on oxygenation in clinical horses under general anesthesia

Levionnois¹,

Zuehlke²,

Kuhn³

et al. 2016

PHK

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Summary:The objective was to compare the use of 0.3 and >0.95 oxygen inspired fraction during general anesthesia in horses. Forty client-owned adult horses were anesthetized in dorsal or in lateral recumbency with isoflurane in oxygen and randomly allocated to receive inspiratory fraction of oxygen >0.95 (group HIGH) or 0.3 (group LOW). Mechanical ventilation was provided using pressure controlled mode. Arterial blood gas analysis was performed before, during and after general anesthesia. The group LOW obtained lower intra-operative PaO 2 values but better indices of venous admixture than the group HIGH. The PaO 2 further decreased during the recovery, without significant differences between groups. Even though the use of lower oxygen inspired fraction (0.3) tended to improve pulmonary function during general anesthesia, it markedly decreased safety as a result of hypoxemia. During the recovery, no difference was observed between groups for the arterial oxygenation such that lower intra-anesthetic oxygen inspired fraction did not provide any advantages.

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“…; Briganti et al. ):

[false({Cc}^{'} O_{2} - {CaO}_{2} false) / false({Cc}^{'} O_{2} - {CaO}_{2} + 3.5 mL {dL}^{- 1} false)] \times 100

…”

Section: Methodsunclassified

“…The degree of impairment of alveolar oxygen exchange and pulmonary venous admixture were estimated with the O 2 content-based index Fshunt. The Fshunt was calculated as follows using previously reported equations (Araos et al 2012;Briganti et al 2015):…”

Section: Anaesthesia Maintenance and Monitoringmentioning

confidence: 99%

Cardiopulmonary effects and anaesthesia recovery quality in horses anaesthetized with isoflurane and low‐dose S‐ketamine or medetomidine infusions

Menzies

Ringer

Conrot

et al. 2016

Veterinary Anaesthesia and Analgesia

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Accuracy of different oxygenation indices in estimating intrapulmonary shunting at increasing infusion rates of dobutamine in horses under general anaesthesia

Cited by 27 publications

References 23 publications

Effect of reducing inspired oxygen concentration on oxygenation parameters during general anaesthesia in horses in lateral or dorsal recumbency

Effect of reducing inspired oxygen concentration on oxygenation parameters during general anaesthesia in horses in lateral or dorsal recumbency

Impact of low inspired oxygen fraction on oxygenation in clinical horses under general anesthesia

Cardiopulmonary effects and anaesthesia recovery quality in horses anaesthetized with isoflurane and low‐dose S‐ketamine or medetomidine infusions

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