Accuracy of Faecal Calprotectin and Neutrophil Gelatinase B-associated Lipocalin in Evaluating Subclinical Inflammation in UlceRaTIVE Colitis—the ACERTIVE study

Magro, Fernando; Lopes, Susana; Coelho, Rosa; Cotter, José; Castro, Francisca Dias de; Sousa, Helena Tavares de; Salgado, Marta; Andrade, Patrícia; Vieira, Ana Isabel; Figueiredo, Pedro; Caldeira, Paulo; Sousa, A; Duarte, Maria Antónia; Ávila, Filipa; Silva, João; Moleiro, Joana; Mendes, Sofia; Giestas, Sílvia; Ministro, Paula; Sousa, Paula; Gonçalves, Raquel; Gonçalves, Bruno; Oliveira, Ana Maria; Chagas, Cristina; Torres, Joana; Dias, Cláudia Camila; Lopes, Joanne; Borralho, Paula; Afonso, Joana; Geboes, Karel; Carneiro, Fátima

doi:10.1093/ecco-jcc/jjw170

Cited by 20 publications

(17 citation statements)

References 37 publications

(47 reference statements)

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“…The cutoff values can influence the test accuracy and there are different cutoff values for FC depending on the intent of use. The current National Institute for Health and Care Excellence (NICE) guideline [78] indicates that an FC value <50 μg/g suggest no significant GI mucosal inflammation, with a value of >250 μg/g corresponds well with endoscopic and histology activity [9,79]. The cutoff values used in the studies presented in this systematic review were not uniform.…”

Section: Discussionmentioning

confidence: 99%

Does fecal calprotectin equally and accurately measure disease activity in small bowel and large bowel Crohn’s disease?: a systematic review

et al. 2019

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Fecal calprotectin (FC) is a highly sensitive disease activity biomarker in inflammatory bowel disease. However, there are conflicting reports on whether the diagnostic accuracy in Crohn’s disease is influenced by disease location. The aim of this study was to undertake a systematic review of the published literature. Relevant databases were searched from inception to November 8, 2016 for cohort and case control studies which had data on FC in patients with isolated small bowel (SB) and large bowel (LB) Crohn’s disease. Reference standards for disease activity were endoscopy, magnetic resonance imaging, computed tomography or a combination of these. The QUADAS-2 research tool was used to assess the risk of bias. There were 5,619 records identified at initial search. The 2,098 duplicates were removed and 3,521 records screened. Sixty-one full text articles were assessed for eligibility and 16 studies were included in the final review with sensitivities and specificities per disease location available from 8 studies. Sensitivities of FC at SB and LB locations ranged from 42.9% to 100% and 66.7% to 100% respectively while corresponding specificities were 50% to 100% and 28.6% to 100% respectively. The sensitivities and specificities of FC to accurately measure disease activity in Crohn’s disease at different disease locations are diverse and no firm conclusion can be made. Better studies need to be undertaken to categorically answer the effect of disease location on the diagnostic accuracy of FC.

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Section: Discussionmentioning

confidence: 99%

Does fecal calprotectin equally and accurately measure disease activity in small bowel and large bowel Crohn’s disease?: a systematic review

et al. 2019

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“…For many years, Lcn2 has been recognized as an emerging player in different physiological and pathological processes, including iron homeostasis, inflammation, microbial infection, organogenesis, neurodegeneration, and tumorigenesis [16–18]. Meanwhile, its broad expression in various tissues and cell types and its detectable size and relative stability make it potentially useful both as a diagnostic biomarker and as a prognostic indicator for several diseases, including inflammatory bowel disease [19, 20] and sepsis-related acute kidney injury [21, 22]. In the field of intestinal inflammation and critical illnesses, Lcn2 appears to be of clinical relevance in gut-origin sepsis.…”

Section: Introductionmentioning

confidence: 99%

Functions and regulation of lipocalin-2 in gut-origin sepsis: a narrative review

Irie

Kato

et al. 2019

Crit Care

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Lipocalin-2 (Lcn2), an innate immune protein, has come to be recognized for its roles in iron homeostasis, infection, and inflammation. In this narrative review, we provide a comprehensive description based on currently available evidence of the clinical implications of Lcn2 and its therapeutic potency in gut-origin sepsis. Lcn2 appears to mitigate gut barrier injury via maintaining homeostasis of the microbiota and exerting antioxidant strategy, as well as by deactivating macrophages and inducing immune cell apoptosis to terminate systemic hyper-inflammation. We propose that development of a therapeutic strategy targeting lipocalin-2 could be highly promising in the management of gut-origin sepsis.

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“…A limitation of this study is the fact that we could not investigate the NEC histological aspects in patients without symptoms as the follow-up of the patients by colonoscopy and subsequent histological analysis of the biopsies is vastly replaced by the use of surrogate markers, such as calprotectin 23,24 . Hence, we could only assess patients with histological scores or inflammation ranging from mildly to severely active inflammation activity, though patients with a Mayo score of 0 were included in the study.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological Correlations Of Neuroendocrine Cell Hyperplasia In Ulcerative Colitis Patients

Curte¹,

NICOLAE²,

CHIVU³

et al. 2020

Arch Balk Med Union

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Corrélations cliniques et pathologiques de l'hyperplasie des cellules neuro-endocrines chez les patients atteints de colite ulcéreuse Introduction. Plusieurs études ont montré que les cellules neuro-endocrines (CNE) sont accrues dans la muqueuse colorectale des patients atteints de colite ulcéreuse (CU) par rapport à la normale, principalement dans le côlon gauche. Un seuil de 3,2 NEC / crypte a été proposé par certains auteurs pour définir l'hyperplasie CNE chez ces patients. Cependant, les corrélations des changements de CNE avec les paramètres cliniques n'ont pas été décrites. L'objectif de cette étude était d'analyser les changements histologiques NEC, décrits par plusieurs décripteurs, chez les patients CU et d'identifier les corrélations clinico-pathologiques pertinentes. Matériel et méthodes. Nous avons analysé les biopsies coliques de 42 patients avec CU en mettant en évidence les cellules neuro-endocrines avec une coloration immunohistochimique à la Chromogranine A.

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Accuracy of Faecal Calprotectin and Neutrophil Gelatinase B-associated Lipocalin in Evaluating Subclinical Inflammation in UlceRaTIVE Colitis—the ACERTIVE study

Cited by 20 publications

References 37 publications

Does fecal calprotectin equally and accurately measure disease activity in small bowel and large bowel Crohn’s disease?: a systematic review

Does fecal calprotectin equally and accurately measure disease activity in small bowel and large bowel Crohn’s disease?: a systematic review

Functions and regulation of lipocalin-2 in gut-origin sepsis: a narrative review

Clinicopathological Correlations Of Neuroendocrine Cell Hyperplasia In Ulcerative Colitis Patients

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