Accuracy of Finnish Cancer Registry colorectal cancer data: a comparison between registry data and clinical records

Lunkka, Pipsa; Malila, Nea; Ryynänen, Heidi; Heikkinen, Sanna; Sallinen, Ville; Koskenvuo, Laura

doi:10.1080/00365521.2020.1867893

Cited by 15 publications

(17 citation statements)

References 13 publications

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“…Previously, both FCR and HILMO have shown to have above 90% completeness for oesophageal cancer 10. A good accuracy of FCR was also indicated by a similar study for colorectal cancer 9. A Swedish study, on the other hand, indicated a substantial underreporting of pancreatic and biliary cancers in the Swedish Cancer Registry 16.…”

Section: Discussionmentioning

confidence: 81%

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Gastric cancer completeness in Finnish Cancer Registry and Finnish Patient Registry: a population-based nationwide retrospective cohort study

Maharjan

Kauppila

2022

BMJ Open

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BackgroundGastric cancer is the fourth-leading cause of cancer-related deaths worldwide. The only curative treatment options of gastric cancer are perioperative chemotherapy and surgical resection. Many nationwide registries have high validity and provide vast range of opportunities for registry-based research. Cancer diagnoses in the Finnish Cancer Registry (FCR) are reported by pathology laboratories and clinician forms, while discharge diagnosis codes are reported to the Finnish Patient Registry (HILMO) automatically. Finland is known for complete registries but the completeness of gastric cancer in FCR and HILMO remains unclear.ObjectivesThe aim of this study is to assess the registry coverage for gastric cancer in FCR and HILMO and to explore potential reasons for possible differences between these registries.DesignPopulation-based nationwide retrospective cohort study.ParticipantsAll patients diagnosed with gastric cancer in Finland during 1990 to 2014, with follow-up until 31 December 2019.ResultsOut of 21 468 total gastric cancers reported to either registry, 17 107 (79.7%) had a gastric cancer diagnosis in both registries. A substantial decrease from 88.3% to 83.4% was observed in the proportion of cases reported to FCR over time. The completeness of FCR was estimated at 87%. For HILMO, the completeness was 92.7%. Death due to gastric cancer was most common in those with gastric cancer in both registries (80.8%), and less common in those reported to only FCR (36.3%), followed by those reported to only HILMO (9.3%).ConclusionsThe study indicates that gastric cancer is well captured by both FCR and HILMO but there is an alarming decrease in the proportion of cases captured by the FCR over time. Some gastric cancer diagnoses in HILMO might, however, be misclassified due to cancer diagnoses being assigned based on clinical suspicion.

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Section: Discussionmentioning

confidence: 81%

“…A previous study in Finland showed that FCR data had good accuracy regarding colorectal cancer 9. Completeness of both FCR and HILMO was found to be above 90% for oesophageal cancer 10.…”

Section: Introductionmentioning

confidence: 88%

Gastric cancer completeness in Finnish Cancer Registry and Finnish Patient Registry: a population-based nationwide retrospective cohort study

Maharjan

Kauppila

2022

BMJ Open

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“…Despite this limitation, the use of this kind of classification also allows for the inclusion of cases with incomplete information. Recently, one study showed that the FCR classification agrees fairly well with the TNM staging classification [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

“…We found that, over time, when comparing patients diagnosed between 1991 and 2005 with those diagnosed between 2006 and 2015, both DSS and relative survival improved. Cancer-specific data on staging received from FCR relies on FCR’s own classification for tumour spread [ 10 ]. It is, however, fairly comparable to the TNM staging classification.…”

Section: Discussionmentioning

confidence: 99%

“…FCR registers CRC using their own classification, which is not entirely comparable to the traditional TNM staging classification (Table 1 ) [ 10 ]. We received information on the tumour stage based on FCR’s classification as follows: 0) unknown; 1) localised; 2) nonlocalised with only regional lymph node metastases; 3) metastasised further than to regional lymph nodes or invasion to adjacent tissues; 4) nonlocalised with no information on extent; 5) locally advanced with the tumour invading adjacent tissues; and 6) nonlocalised with distant lymph node metastases as well.…”

Section: Methodsmentioning

confidence: 99%

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Long-term survival among colorectal cancer patients in Finland, 1991–2015: a nationwide population-based registry study

et al. 2022

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Background Colorectal cancer (CRC) incidence in Finland has risen steadily. Given development in cancer treatments in recent decades, disease-specific data on the long-term prognosis of patients may be obsolete. Thus, this study aimed to report 5-year disease-specific survival (DSS) and relative survival based on tumour spread and site among CRC patients diagnosed between 1991 and 2015 in Finland. Material and methods We conducted a population-based registry study among 59 465 CRC patients identified from the Finnish Cancer Registry. Results The 5-year DSS for all CRC patients was 56.7% [95% confidence interval (CI) 56.3–57.1%] for 1991 through 2015. Tumour site-specific survival has improved for the period 2006–2015 versus 1991–2005 for right-sided colon cancer from 54.8% (95% CI 53.8–55.8%) to 59.9% (95% CI 58.7–61.1%), for left-sided colon cancer from 54.1% (95% CI 52.9–55.3%) to 61.0% (95% CI 59.8–62.2%) and for rectal cancer from 53.6% (95% CI 52.2–55.0%) to 62.3% (95% CI 61.3–63.3%). The 5-year relative survival for the period 2006 through 2015 was 93.6% for localised disease (stage I); 84.2% for locally advanced tumour invading adjacent structures (stage II); 68.2% for regional disease with regional lymph node metastases (stage III); and 14.0% for metastatic disease (stage IV). Conclusions This study confirms that survival for CRC has improved in recent decades in Finland, mirroring observations from other Western countries. However, the classification of tumour spread within the Finnish Cancer Registry differs slightly from the TNM classification, thereby limiting the generalisability of these results.

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Shared environment and colorectal cancer: A Nordic pedigree registry‐based cohort study

Elmahdi

Wennerström

Andersson

et al. 2022

Intl Journal of Cancer

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Risk of colorectal cancer (CRC) increases in relatives of patients with CRC. The extent to which this is attributable to genetic predisposition or shared environment is unclear. We explored this question using nationwide cohorts from Denmark, Finland and Sweden. From 1977 to 2013, we identified 359 879 individuals with a CRC diagnosis and 2 258 870 of their relatives who we followed for CRC incidence. We calculated standardized incidence ratios (SIR) and 95% confidence intervals (CI) for CRC in individuals with an affected relative. We used nationwide household and pedigree data along with national SIR estimates to calculate risk ratios (RR) for the contribution of shared household environment, childhood environment and genetic relationship to CRC risk in those with an affected relative. SIR of CRC was increased for individuals with an affected relative, across all countries and ages. For those with an affected parent, the SIR was 1.65 (95% CI: 1.61‐1.69), 1.98 (95% CI: 1.87‐2.09), for those with an affected sibling and 2.14 (95% CI: 1.84‐2.49) for those with an affected halfsibling. In those <65 years old, shared childhood (RR: 1.41, 95% CI: 1.26‐1.57) and household (RR: 2.08, 95% CI: 1.25‐3.46) environments were significantly greater contributors to familial risk of CRC than genetics (RR: 0.88, 95% CI: 0.53‐1.46). This large‐scale Nordic population‐based study of excess risk of CRC among relatives of those with CRC addresses the difficult disentangling of shared environment from genetic predisposition in the heritability of CRC. We found shared environment to be the most important contributor to CRC risk.

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Accuracy of Finnish Cancer Registry colorectal cancer data: a comparison between registry data and clinical records

Cited by 15 publications

References 13 publications

Gastric cancer completeness in Finnish Cancer Registry and Finnish Patient Registry: a population-based nationwide retrospective cohort study

Gastric cancer completeness in Finnish Cancer Registry and Finnish Patient Registry: a population-based nationwide retrospective cohort study

Long-term survival among colorectal cancer patients in Finland, 1991–2015: a nationwide population-based registry study

Shared environment and colorectal cancer: A Nordic pedigree registry‐based cohort study

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