Accuracy of frozen-section (intraoperative consultation) diagnosis of ovarian tumors

Rose, Peter G.; Rubin, Ronald; Nelson, Beth E.; Hunter, Richard; Reale, Frank R.

doi:10.1016/0002-9378(94)90105-8

Cited by 119 publications

(122 citation statements)

References 13 publications

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“…In our study, inadequate and inappropriate tissue sampling due to huge tumors during operation was the reasons for the cases with benign frozen but borderline paraffin block results. In our study on 30 patients, sensitivity for malignant tumors was 71.4%.A recently published meta analysis of 18 studies comparing frozen and histopath showed sensitivity for malignant tumors as 71 to 100% [13] . In our study 5 diagnosed as malignant on frozen turned out to be malignant.…”

Section: Discussionsupporting

confidence: 42%

Role of Frozen Section in the Intra operative management of Ovarian Neoplasms and Comparing with Final Histopathological Diagnosis – A Prospective Study

Maheshwari¹

2017

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Section: Discussionsupporting

confidence: 42%

Role of Frozen Section in the Intra operative management of Ovarian Neoplasms and Comparing with Final Histopathological Diagnosis – A Prospective Study

Maheshwari¹

2017

jmscr

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“…However, frozen section diagnosis of BTO is less reliable than frozen section diagnosis of benign or malignant ovarian tumors. [5][6][7][8][9][10][11][12][13][14] Thus, some investigators have sought to find significant factors related to misdiagnosis. Houck et al 8 found that mucinous histology was the only significant predictor for under-diagnosis by frozen section.…”

Section: Introductionmentioning

confidence: 99%

Clinical analysis of intra-operative frozen section proven borderline tumors of the ovary

Kim

Park

et al. 2009

J Gynecol Oncol

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Objective:We have assessed the accuracy of frozen section diagnosis and the outcomes of misdiagnosis in borderline tumors of the ovary (BTO) according to frozen section. Methods: All pathology reports with BTO in both frozen and permanent section analyses between 1994 and 2008 at Seoul St. Mary's Hospital were reviewed. Frozen section diagnosis and permanent section histology reports were compared. Logistic regression models were conducted to evaluate the correlation of patient and tumor characteristics with diagnostic accuracy. The clinical outcomes of misdiagnosis were evaluated. Results: Agreement between frozen section diagnosis and permanent histology was observed in 63 of 101 patients (62.4%). Among the 76 patients with frozen section proven BTO, under-diagnosis and over-diagnosis occurred in 8 of 76 (10.5%) and 5 of 76 patients (6.6%), respectively. Mean diameter of under-diagnosed tumor was larger than matched BTO (21.0±11.4 vs. 13.7±7.1; p=0.021). Tumor size 20 cm was determined as the optimal cut-off for under-diagnosis (50% sensitivity, 87.3% specificity). Among 8 under-diagnosed patients, no patient relapsed. Among 5 over-diagnosed patients, 2 patients ＜ 35 years of age had fertility-preserving surgery. Conclusion: Although frozen section diagnosis is an important and reliable tool in the clinical management of patients with ovarian tumors, over-diagnosis and under-diagnosis are relatively frequent in frozen proven BTO. Surgical decision-making for BTO based on frozen section diagnosis should be done carefully, especially in large tumors.

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“…4 Frozen sections of the tumors were correctly reported to be benign, but their precise nature was diagnosed erroneously in comparison to diagnosis using permanent sections. The inaccuracy in the frozen-section results was attributed to microscope sampling (case 1), and technical inability to cut calcified tissue (case 2).…”

Section: Discussionmentioning

confidence: 99%

“…The urgency of releasing intraoperative reports restricts the number of sections examined to below the ideal, especially when large specimens are submitted. 4 Merely reporting a "benign" or "malignant" diagnosis may be enough to satisfy the surgeon's need to promote appropriate care for the patient. It will continue to be difficult to accurately diagnose cystic struma from frozen sections, because of the extensive sampling required and the inexperience of pathologists with this extremely rare tumor.…”

Section: Discussionmentioning

confidence: 99%

Cystic struma ovarii: a rare presentation of an infrequent tumor

et al. 2000

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Accuracy of frozen-section (intraoperative consultation) diagnosis of ovarian tumors

Cited by 119 publications

References 13 publications

Role of Frozen Section in the Intra operative management of Ovarian Neoplasms and Comparing with Final Histopathological Diagnosis – A Prospective Study

Role of Frozen Section in the Intra operative management of Ovarian Neoplasms and Comparing with Final Histopathological Diagnosis – A Prospective Study

Clinical analysis of intra-operative frozen section proven borderline tumors of the ovary

Cystic struma ovarii: a rare presentation of an infrequent tumor

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