Purpose: To compare the efficacy and safety of conventional scleral fixation, retropupillary iris-claw intraocular lens (IOL) implantation, and intrascleral fixation Methods: This retrospective observational study included 58 patients (58 eyes) who underwent conventional scleral fixation (C-SF, 23 eyes), retropupillary iris-claw IOL implantation (RP-IOL, 23 eyes), and intrascleral fixation (ISF, 12 eyes) by a single surgeon at Samsung Medical Center from October 2017 to July 2020 and were followed up for at least 6 months. This study analyzed various clinical outcomes before and 1 day, 1 week, 1 month, 3 months, and 6 months after surgery.Results: Six months after surgery, best-corrected visual acuity (BCVA) in logarithm of minimum angle of resolution was 0.08 ± 0.10, 0.08 ± 0.16, and 0.03 ± 0.04 in C-SF group, RP-IOL group, and ISF group, respectively, and there was a significant improvement in each group compared to preoperative BCVA. All groups showed a significant increase in astigmatism postoperatively, but no between-group differences were observed. The prediction error was -0.15 ± 0.77, 0.56 ± 0.62, and 0.44 ± 1.00 diopters in the three groups, respectively, indicating RP-IOL group and ISF group for hyperopic shift.The three groups did not differ in terms of absolute prediction error. Six months after surgery, the corneal endothelial cell counts were 2073 ± 691, 2014 ± 692, and 1712 ± 891 cells/mm 2 , respectively, which were lower than before surgery. IOL dislocation occurred in five eyes only in RP-IOL group, two of which underwent two reoperations, and re-enclavation was performed smoothly without complications in all cases.Conclusions: Although the frequency of IOL dislocation in RP-IOL group was higher than that in the other groups, it can be re-enclavated relatively easily. As a method of secondary IOL fixation, both RP-IOL implantation and intrascleral fixation were as effective as conventional scleral fixation.