Accuracy of Intraoperative Frozen Section Diagnosis of Ovarian Tumors

Pinto, Paola Bertolotti Cardoso; Andrade, Liliana Aparecida Lucci De Angelo; Derchain, Sophie

doi:10.1006/gyno.2001.6133

Cited by 88 publications

(88 citation statements)

References 10 publications

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“…Pinto et al, 21 conducted a study on 243 ovarian biopsies received for frozen section and the results showed 93% sensitivity and 99% specificity, similar to our study.…”

Section: 17supporting

confidence: 67%

Diagnostic accuracy of intraoperative consultation of ovarian neoplasms

et al. 2014

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Introduction: Ovarian neoplasm's are an important cause of morbidity and mortality in women. Frozen section is widely used in the intra-operative assessment of patients with ovarian tumors to provide guidance for an appropriate surgical management. It is crucial to know intra-operatively, the exact nature of the tumor to determine the extent of surgery. It is in these situations where the Intraoperative frozen section technique plays its role in making this distinction. Methodology: Females of all ages undergoing planned surgeries for ovarian tumors at Aga Khan Hospital or outside referrals with request for intra operative diagnosis was included. Age of the patient, duration of the lesion and clinical impression were recorded and frozen section was performed. Results: Thirty four cases of ovarian tumors received for frozen section were included in this study. The calculated sensitivity was94.4%, specificity was 93.8%, positive predictive value was 94.4% and negative predictive value was 93.8%. Conclusion: This study shows that frozen section is a highly sensitive and specific method for the rapid diagnosis of ovarian tumors.

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“…Pinto et al, 21 conducted a study on 243 ovarian biopsies received for frozen section and the results showed 93% sensitivity and 99% specificity, similar to our study.…”

Section: 17supporting

confidence: 67%

Diagnostic accuracy of intraoperative consultation of ovarian neoplasms

et al. 2014

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“…16 Frozen section diagnosis agrees with permanent pathology of malignancy in 90-94% of cases. 17,18 However, frozen section diagnosis of BTO is less reliable. 8,10 In the pooled data analysis, Tempfer et al 9 reported that agreement between frozen section diagnosis and definitive histology was observed in 199/317 (62.8%) patients.…”

Section: Discussionmentioning

confidence: 99%

Clinical analysis of intra-operative frozen section proven borderline tumors of the ovary

Kim

Park

et al. 2009

J Gynecol Oncol

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Objective:We have assessed the accuracy of frozen section diagnosis and the outcomes of misdiagnosis in borderline tumors of the ovary (BTO) according to frozen section. Methods: All pathology reports with BTO in both frozen and permanent section analyses between 1994 and 2008 at Seoul St. Mary's Hospital were reviewed. Frozen section diagnosis and permanent section histology reports were compared. Logistic regression models were conducted to evaluate the correlation of patient and tumor characteristics with diagnostic accuracy. The clinical outcomes of misdiagnosis were evaluated. Results: Agreement between frozen section diagnosis and permanent histology was observed in 63 of 101 patients (62.4%). Among the 76 patients with frozen section proven BTO, under-diagnosis and over-diagnosis occurred in 8 of 76 (10.5%) and 5 of 76 patients (6.6%), respectively. Mean diameter of under-diagnosed tumor was larger than matched BTO (21.0±11.4 vs. 13.7±7.1; p=0.021). Tumor size 20 cm was determined as the optimal cut-off for under-diagnosis (50% sensitivity, 87.3% specificity). Among 8 under-diagnosed patients, no patient relapsed. Among 5 over-diagnosed patients, 2 patients ＜ 35 years of age had fertility-preserving surgery. Conclusion: Although frozen section diagnosis is an important and reliable tool in the clinical management of patients with ovarian tumors, over-diagnosis and under-diagnosis are relatively frequent in frozen proven BTO. Surgical decision-making for BTO based on frozen section diagnosis should be done carefully, especially in large tumors.

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“…Several studies have demonstrated that frozen section accurately distinguishes invasive from benign ovarian tumors [12][13][14][15][16][17], whereas this method is less accurate for large or borderline (low-malignantpotential) ovarian tumors [16].…”

Section: Introductionmentioning

confidence: 99%

MR imaging compared with intraoperative frozen-section examination for the diagnosis of adnexal tumors; correlation with final histology

et al. 2006

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The aim was to compare the accuracy of magnetic resonance imaging (MRI) and intraoperative consultation (IC) for the diagnosis of adnexal masses, with reference to final histology. MRI was performed in 136 women with sonographically indeterminate adnexal masses. IC included macroscopic and frozen-section examination. Macroscopic examination and MRI determined size, nature, and presence of vegetations or solid portions within masses. All masses were characterized as benign or malignant according to previously published MR imaging and histopathologic criteria. Sensitivities, specificities, and predictive values for the diagnosis of malignancy of MRI and IC were assessed. Histology revealed 168 adnexal masses (99 benign, 23 borderline and 46 invasive). Frozen sections were examined in 151 cases. Among the 151 adnexal masses studied by both MRI and IC, respective sensitivities, specificities, positive and predictive values of both methods for the diagnosis of malignancy were 89.7% and 84.5%, 91.4% and 100%, 86.7% and 100%, and 93.4% and 91.3%. Sensitivities of MR imaging and frozen section for the diagnosis of serous versus mucinous borderline tumors were 33.3% and 93.3%, and 62.5% and 12.5%, respectively. MRI is less accurate than IC for characterizing adnexal masses. However, MRI may increase the relevance of IC for borderline mucinous tumors.

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Accuracy of Intraoperative Frozen Section Diagnosis of Ovarian Tumors

Cited by 88 publications

References 10 publications

Diagnostic accuracy of intraoperative consultation of ovarian neoplasms

Diagnostic accuracy of intraoperative consultation of ovarian neoplasms

Clinical analysis of intra-operative frozen section proven borderline tumors of the ovary

MR imaging compared with intraoperative frozen-section examination for the diagnosis of adnexal tumors; correlation with final histology

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