Accuracy of Plasma Free Metanephrines in the Diagnosis of Pheochromocytoma and Paraganglioma: a Systematic Review and Meta-analysis

Chen, Yan; Xiao, Huangmeng; Zhou, Xieda; Huang, Xiaoyu; Li, Yanbing; Xiao, Hang; Cao, Xiaopei

doi:10.4158/ep171877.or

Cited by 23 publications

(11 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Inclusion of 3methoxytyramine is useful for detecting dopamine-producing PPGLs when measured in plasma but not urine. Both plasma and urinary free metabolites have near maximal negative predictive values (>99%) at similar specificities (94%) [40][41][42]. Measurements in plasma show similar diagnostic accuracy as those in urine in patients at low risk, such as those tested due to signs and symptoms, but are superior to those in urine in patients at high risk for a PPGL, such as those tested due to an incidentaloma or as part of surveillance screening [40].…”

Section: What Is the Preferred Initial Biochemical Test?mentioning

confidence: 88%

Genetics, diagnosis, management and future directions of research of phaeochromocytoma and paraganglioma: a position statement and consensus of the Working Group on Endocrine Hypertension of the European Society of Hypertension

Lenders

Kerstens

Amar

et al. 2020

Journal of Hypertension

262

355

View full text Add to dashboard Cite

show abstract

Section: What Is the Preferred Initial Biochemical Test?mentioning

confidence: 88%

Genetics, diagnosis, management and future directions of research of phaeochromocytoma and paraganglioma: a position statement and consensus of the Working Group on Endocrine Hypertension of the European Society of Hypertension

Lenders

Kerstens

Amar

et al. 2020

Journal of Hypertension

262

355

View full text Add to dashboard Cite

show abstract

“…The diagnostic performance of plasma free metanephrines was significantly higher than urinary catecholamines or vanillylmandelic acid based on the receiver operating curve analysis. A metaanalysis of the diagnostic accuracy of plasma free metanephrines estimated the pooled sensitivity and specificity as 97% and 94% [37].…”

Section: Biochemical Tests Of Pheochromocytoma/paraganglioma 21 Initial Biochemical Tests Of Ppgl Should Include Measurements Of Plasma Fmentioning

confidence: 99%

Diagnosis for Pheochromocytoma and Paraganglioma: A Joint Position Statement of the Korean Pheochromocytoma and Paraganglioma Task Force

Kim

et al. 2021

Endocrinol Metab

View full text Add to dashboard Cite

Pheochromocytoma and paraganglioma (PPGLs) are rare catecholamine-secreting neuroendocrine tumors but can be life-threatening. Although most PPGLs are benign, approximately 10% have metastatic potential. Approximately 40% cases are reported as harboring germline mutations. Therefore, timely and accurate diagnosis of PPGLs is crucial. For more than 130 years, clinical, molecular, biochemical, radiological, and pathological investigations have been rapidly advanced in the field of PPGLs. However, performing diagnostic studies to localize lesions and detect metastatic potential can be still challenging and complicated. Furthermore, great progress on genetics has shifted the paradigm of genetic testing of PPGLs. The Korean PPGL task force team consisting of the Korean Endocrine Society, the Korean Surgical Society, the Korean Society of Nuclear Medicine, the Korean Society of Pathologists, and the Korean Society of Laboratory Medicine has developed this position statement focusing on the comprehensive and updated diagnosis for PPGLs.

show abstract

“…Indeed, the PFM have the highest diagnostic sensitivity [20,21], especially in hereditary contexts [22,23]. However, their measurement may fail to identify tumors that secrete small amounts of catecholamines or those that produce only dopamine [24]. In our series, this dosage, which was performed on 10 patients (25%), was found to be high in 90% of cases.…”

Section: Discussionmentioning

confidence: 77%

Presentation and management of pheochromocytomas and paragangliomas: about 40 cases

et al. 2021

View full text Add to dashboard Cite

Background Pheochromocytoma and paraganglioma are rare neuroendocrine tumors of the chromaffin tissue, which may produce catecholamines. The aim of our study was to analyze the clinical and para-clinical aspects as well as the therapeutic and evolutionary aspects of pheocromocytomas and paragangliomas based on a series of 40 cases. Methods Our retrospective population-based research study includes 40 patients. Then, a statistical analysis was carried out using the SPSS software (version21). Results Our study involves 40 patients, including 23 women (57, 5%) and 17 men (42,5%). The mean age at the time of the diagnosis was 43.8 ± 16.8 years. The circumstances of the discovery were mainly characterized by adrenal incidentaloma and hypertension. The biological diagnosis was based on the dosage of urinary metanephrines and plasma-free metanephrines in, respectively, 61.5% and 18% of cases. A computerized tomography scan and/or a magnetic resonance imaging scan could help to locate the tumor in 100% of cases. Our series includes 3 cases of bilateral pheochromocytoma, 3 cases of paragangliomas and 1 case of malignant pheochromocytoma, while a hereditary form was retained in 3 patients. In fact, thirty-two patients were operated; cure was clinically labeled in 100% and biologically in 87.5% of patients. Conclusions The main points for improvement that our study has revealed are; a patient follow-up after surgery, which was not always regular, and an insufficient screening for genetic diseases associated with pheochromocytomas and paragangliomas.

show abstract

Accuracy of Plasma Free Metanephrines in the Diagnosis of Pheochromocytoma and Paraganglioma: a Systematic Review and Meta-analysis

Cited by 23 publications

References 37 publications

Genetics, diagnosis, management and future directions of research of phaeochromocytoma and paraganglioma: a position statement and consensus of the Working Group on Endocrine Hypertension of the European Society of Hypertension

Genetics, diagnosis, management and future directions of research of phaeochromocytoma and paraganglioma: a position statement and consensus of the Working Group on Endocrine Hypertension of the European Society of Hypertension

Diagnosis for Pheochromocytoma and Paraganglioma: A Joint Position Statement of the Korean Pheochromocytoma and Paraganglioma Task Force

Presentation and management of pheochromocytomas and paragangliomas: about 40 cases

Contact Info

Product

Resources

About