Accuracy of prenatal and postnatal biomarkers for estimating gestational age: a systematic review and meta-analysis

Bradburn, Elizabeth; Conde-Agudelo, Agustin; Roberts, Nia W.; Villar, Jose; Papageorghiou, Aris T.

doi:10.1016/j.eclinm.2024.102498

Cited by 1 publication

(2 citation statements)

References 52 publications

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“…N time period was specified, and duplicate articles were removed. The investigation about possible markers that can be used for diagnostic and therapeutic purposes is very active in human medicine, and this is demonstrated by the publication of several recent papers concerning this topic [14][15][16]. Metabolomics can be used to clarify the pathogenetic mechanisms underlying certain diseases or even for research concerning mechanisms underlying the interaction between pathogens and the host.…”

Section: Methodsmentioning

confidence: 99%

“…Even if the only post-processing steps of the spec tra were referencing alanine's signals at 1.46 ppm and normalization, the horizontal pos tion of the signals (chemical-shift) from branched amino acids appears as perfectly con sistent across the entire samples' set. The investigation about possible markers that can be used for diagnostic and thera peutic purposes is very active in human medicine, and this is demonstrated by the publ cation of several recent papers concerning this topic [14][15][16]. Metabolomics can be used t clarify the pathogenetic mechanisms underlying certain diseases or even for research con cerning mechanisms underlying the interaction between pathogens and the host.…”

Section: Introductionmentioning

confidence: 99%

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Nuclear Magnetic Resonance (NMR) Metabolomics: Current Applications in Equine Health Assessment

Laus,

Bazzano,

Spaterna

et al. 2024

Metabolites

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Metabolomics can allow for the comprehensive identification of metabolites within biological systems, at given time points, in physiological and pathological conditions. In the last few years, metabolomic analysis has gained popularity both in human and in veterinary medicine, showing great potential for novel applications in clinical activity. The aim of applying metabolomics in clinical practice is understanding the mechanisms underlying pathological conditions and the influence of certain stimuli (i.e., drugs, nutrition, exercise) on body systems, in the attempt of identifying biomarkers that can help in the diagnosis of diseases. Proton Nuclear Magnetic Resonance spectroscopy (1H-NMR) is well tailored to be used as an analytical platform for metabolites’ detection at the base of metabolomics studies, due to minimal sample preparation and high reproducibility. In this mini-review article, the scientific production of NMR metabolomic applications to equine medicine is examined. The research works are very different in methodology and difficult to compare. Studies are mainly focused on exercise, reproduction, and nutrition, other than respiratory and musculoskeletal diseases. The available information on this topic is still scant, but a greater collection of data could allow researchers to define new reliable markers to be used in clinical practice for diagnostic and therapeutical purposes.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%