Accuracy of single measurements of pregnancy-associated plasma protein-A, human chorionic gonadotropin and progesterone in the diagnosis of early pregnancy failure

Dumps, Patrick; Meisser, A.; Pons, Dominique; Morales, Michel; Anguenot, Jean Luc; Campana, A.; Bischof, P.

doi:10.1016/s0301-2115(01)00470-5

Cited by 27 publications

(26 citation statements)

References 23 publications

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“…Although these pregnancies were four times more likely to have occurred after infertility treatment, the results remained unchanged when excluding such pregnancies. Progesterone plays an essential role in the transport of the embryo to the uterus (28), and women with extrauterine pregnancies has been found to have lower progesterone levels than those with normal intrauterine pregnancies (29). Studies have found that lower midluteal progesterone is associated with failure to conceive (30,31).…”

Section: Discussionmentioning

confidence: 99%

Time to pregnancy and pregnancy outcome

Axmon

Hagmar

2005

Fertility and Sterility

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OBJECTIVE: To investigate whether the outcome of a pregnancy is related to the time required to achieve that pregnancy (TTP).DESIGN: The distribution of the TTP for pregnancies ending in multiple birth, early (before week 12) and late (weeks 12-28) miscarriage, stillbirth, and extrauterine pregnancy was compared to that of pregnancies ending in singleton birth. Furthermore, the distribution of the TTP for preterm singleton births was compared to that of fullterm singleton births.

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Section: Discussionmentioning

confidence: 99%

Time to pregnancy and pregnancy outcome

Axmon

Hagmar

2005

Fertility and Sterility

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“…Most other studies include women who had already miscarried. [66][67][68] In contrast to what previous investigators have carried out, where experiments were done on cultured peripheral blood mononuclear cells, 69,70 fluorescent antibody-labeled whole blood was analyzed by flow cytometry in this case. In view of the patient groups that were recruited (pregnant women who were experiencing vaginal bleeding in the first trimester), we aimed to sample smaller volumes of blood (1 mL) for the entire experiment (100 L/cytokine or receptor), compared with a minimum of 50 mL in the peripheral blood mononuclear cell culture experiments.…”

Section: Wwwajogorgmentioning

confidence: 99%

“…23 Several factors in the maternal history (such as age and smoking, biomarkers that include serum hormones levels, and the presence of a retroplacental hematoma on ultrasound scanning) have been investigated as possible predictors of pregnancy outcome in women with TM. [24][25][26][27] It has been shown that after TM, maternal serum inhibin A in combination with other serum markers, such as hCG, are altered in women who subsequently have a first-trimester miscarriage. 28,29 The biomarkers that give the best predictive values are a combination of se-rum progesterone and ␤hCG, with a sensitivity of 88.1% and specificity of 84.3%.…”

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confidence: 99%

Pro- and antiinflammatory cytokines in threatened miscarriages

Calleja‐Agius

Muttukrishna

Pizzey

et al. 2011

American Journal of Obstetrics and Gynecology

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OBJECTIVE:The purpose of this study was to evaluate circulating and intracellular levels of Th1 and Th2 cytokines in women with threatened miscarriage (TM) and subsequent outcome.STUDY DESIGN: Plasma levels of tumor necrosis factor (TNF)-receptors 1 and 2, TNF␣, interferon gamma (IFN␥), and interleukins (IL) -6 and -10 were measured by flow cytometric bead assays in 80 women with TM: 53 women with normal outcome and 27 women who miscarried. Fluorescent antibody labeling was also performed on whole blood in a subgroup of 27 women of TM: 16 women with normal outcome and 11 women who miscarried. RESULTS:Monocyte expression of TNF␣ and circulating levels of TNF␣, IFN␥, IL-10, IL-6, and TNF-R1 were significantly lower, whereas circulating levels of TNF␣/IL-10, IFN␥/IL-10, and TNF␣/IL-6 ratios were significantly higher, in women with TM who subsequently miscarried, compared with the women with normal outcome.CONCLUSION: An increased Th1 type of immune response, which was similar to that observed in preterm delivery, was found in TM cases that were complicated by a subsequent miscarriage.

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“…Recently, a number of immunoassay kits and new methods for hCG determinations have also been reported [9,23 -26]. In this work the nano-Au-chitosan scaffold proposed a sensitive electrochemical immunoassay for serum hCG with a detection limit of 0.26 mIU mL À1 at 3s, which was below the threshold value of 14.3 mIU mL À1 hCG in serum for reliable pregnancy diagnosis [27]. Compared with some other reports, this novel detection strategy exhibited an acceptable accuracy and appeared to be practical, convenient and significant in clinic diagnoses.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Immunoassay of Human Chorionic Gonadotrophin Based on Its Immobilization in Gold Nanoparticles‐Chitosan Membrane

Chen

Yan

et al. 2006

Electroanalysis

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A human chorionic gonadotrophin (hCG) doped gold nanoparticles -chitosan membrane was prepared for forming an immunoconjugate of horseradish peroxidase labeled hCG antibody and hCG on glassy carbon electrode. The nanoparticles provided a congenial environment of the adsorbed proteins. Thus, the immobilized HRP-labeled immunoconjugate showed good enzymatic activity for the oxidation of o-phenylenediamine by H 2 O 2 . With a competitive mechanism, an amperometric method for immunoassay of hCG up to 30 mIU mL À1 with a relatively low detection limit of 0.26 mIU mL À1 at 3s was developed. The hCG immunosensor showed good precision, high sensitivity, acceptable stability and reproducibility.

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Accuracy of single measurements of pregnancy-associated plasma protein-A, human chorionic gonadotropin and progesterone in the diagnosis of early pregnancy failure

Cited by 27 publications

References 23 publications

Time to pregnancy and pregnancy outcome

Time to pregnancy and pregnancy outcome

Pro- and antiinflammatory cytokines in threatened miscarriages

Electrochemical Immunoassay of Human Chorionic Gonadotrophin Based on Its Immobilization in Gold Nanoparticles‐Chitosan Membrane

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