Accuracy of the double indicator method for measurement of extravascular lung water depends on the type of acute lung injury*

Roch, Antoine; Michelet, Pierre; Lambert, Dominique; Delliaux, Stéphane; Saby, Christophe; Perrin, Gilles; Ghez, Olivier; Brégeon, Fabienne; Thomas, Philippe; Carpentier, J.-P.; Papazian, Laurent; Auffray, Jean-Pierre

doi:10.1097/01.ccm.0000114831.59185.02

Cited by 71 publications

(45 citation statements)

References 32 publications

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“…The mean basal EVLW was increased when compared to other reports (31,32). One of the reasons could be due to the age of the piglets (12 to 72 h) in the present study.…”

Section: Methodological Validation For the Assessment Of Evlwcontrasting

confidence: 52%

Sildenafil prevents the increase of extravascular lung water and pulmonary hypertension after meconium aspiration in newborn piglets

Silvera

Blasina

Vaamonde

et al. 2011

Braz J Med Biol Res

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“…The mean basal EVLW was increased when compared to other reports (31,32). One of the reasons could be due to the age of the piglets (12 to 72 h) in the present study.…”

Section: Methodological Validation For the Assessment Of Evlwcontrasting

confidence: 52%

Sildenafil prevents the increase of extravascular lung water and pulmonary hypertension after meconium aspiration in newborn piglets

Silvera

Blasina

Vaamonde

et al. 2011

Braz J Med Biol Res

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“…This accumulation, which is detectable as a body weight gain and as a gradual increase in global end-diastolic volume, can induce pulmonary edema, i.e., an abnormal accumulation of fluid in the extravascular compartments of the lung [23] . We found that the extravascular lung water measured using the transpulmonary thermodilution technique correlates significantly with the respiratory index as an indicator of the respiratory function.…”

Section: Discussionmentioning

confidence: 99%

Extravascular Lung Water Measured Using Single Transpulmonary Thermodilution Reflects Perioperative Pulmonary Edema Induced by Esophagectomy

Sato

Motoyama²,

Maruyama³

et al. 2006

Eur Surg Res

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Pulmonary edema is the most frequent postoperative complication following esophagectomy for thoracic esophageal cancer. We enrolled 23 patients who underwent esophagectomy with extended lymph node dissection for thoracic esophageal cancer in a prospective observational clinical trial. We used the PiCCO device to measure extravascular lung water with the aim of determining whether it correlates with the respiratory index and whether it is predictive of pulmonary complications. Based on constant criteria, the tracheal tubes of 11 patients were removed on the morning of postoperative day 1 (extubation group), while 12 patients remained intubated (intubation group). These two groups significantly differed in that all patients in the extubation group recovered without any pulmonary complications, whereas 4 patients (33%) in the intubation group developed pulmonary complications. The extravascular lung water measured using PiCCO correlated significantly with the respiratory index. In the intubation group, both extravascular lung water and respiratory index were elevated 12 h after surgery and were even higher 24 h after surgery. The extravascular lung water measured using PiCCO reflects the level of postoperative pulmonary edema and predicts the pulmonary complications induced by esophagectomy with extended lymph node dissection.

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“…The widely adopted dose of OA falls in the range of 0.06-0.15 ml/kg, which is mixed thoroughly with 15-20 ml of normal saline solution and injected slowly within 20-30 min [6,[26][27][28][29] , targeting a PaO 2 / FIO 2 ratio of 80-120 mm Hg. Sometimes a dose as small as 0.01 ml/kg [30] is used to produce a very slight lung injury or a dose as high as 0.3 ml/kg [31] is applied to achieve a quite severe lung injury.…”

Section: Oai Modelmentioning

confidence: 99%

Overview of the Pathology of Three Widely Used Animal Models of Acute Lung Injury

Wang

Bodenstein²,

Markstaller³

2008

Eur Surg Res

153

140

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Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are syndromes of acute diffuse damage to the pulmonary parenchyma by a variety of local or systemic insults. Increased alveolar capillary membrane permeability was recognized as the common end organ injury and a central feature in all forms of ALI/ARDS. Although great strides have been made in understanding the pathogenesis of ALI/ARDS and in intensive care medicine, the treatment approach to ARDS is still relying on ventilatory and cardiovascular support based on the recognition of the clinical picture. In the course of evaluating novel treatment approaches to ARDS, 3 models of ALI induced in different species, i.e. the surfactant washout lavage model, the oleic acid intravenous injection model and the endotoxin injection model, were widely used. This review gives an overview of the pathological characteristics of these models from studies in pigs, dogs or sheep. We believe that a good morphological description of these models, both spatially and temporally, will help us gain a better understanding of the real pathophysiological picture and apply these models more accurately and liberally in evaluating novel treatment approaches to ARDS.

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Accuracy of the double indicator method for measurement of extravascular lung water depends on the type of acute lung injury*

Abstract: The double indicator method is useful for evaluation of pulmonary edema in indirect lung injury, as induced by oleic acid, but produces misleading values in direct lung injury, as produced by hydrochloric instillation.

Cited by 71 publications

References 32 publications

Sildenafil prevents the increase of extravascular lung water and pulmonary hypertension after meconium aspiration in newborn piglets

Sildenafil prevents the increase of extravascular lung water and pulmonary hypertension after meconium aspiration in newborn piglets

Extravascular Lung Water Measured Using Single Transpulmonary Thermodilution Reflects Perioperative Pulmonary Edema Induced by Esophagectomy

Overview of the Pathology of Three Widely Used Animal Models of Acute Lung Injury

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