“…For the Sramek-Bernstein equation, initial studies showed disparity from the thermodilution and other reference methods for conditions of higher HRs, irregular heartbeats and hyperdynamic sepsis (Bernstein 1986a, 1986b, Introna et al 1988, Spinale et al 1988, Spinale et al 1989, Castor et al 1990, Wong et al 1990, O'connell et al 1991. Sramek-Bernstein equation led to a non-invasive computer cardiac output monitor (NCCOM) 3 device (BoMed Medical, Irvine, CA, USA) which underwent several revisions in the first few years to address its initial flaws (Williams andCaird 1985, Mickell et al 1990). NCCOM3 revisions 6 and 7 showed good correlation with other reference methods (Masaki et al 1989, Jiveg\aard et al 1990, Clancy et al 1991.…”