Accuracy of transcutaneous bilirubin measurement in preterm low-birth-weight neonates

Chawla, Deepak; Jain, Suksham; Kaur, Gurjit; Sinhmar, Vikas; Guglani, Vishal

doi:10.1007/s00431-013-2142-0

Cited by 24 publications

(18 citation statements)

References 28 publications

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“…The AJO-Neo device is based on such a spectroscopy-based approach where the majority of the information is collected from the vascular bed underneath the nail plate 18 . Thus, we predicted that AJO-Neo will be able to overcome the limitations of the conventional TcB meters i.e., their limited accuracy in preterm infants 34,[36][37][38] , dark skin babies 14,[39][40][41] , neonates having phototherapy 39,[42][43][44][45][46][47] , newborns with low birth weight 48,49 , exclusively breastfed infants 34,[50][51][52] , neonates with higher postnatal age 34 and high TSB value 34,[53][54][55] , etc.…”

Section: Discussionmentioning

confidence: 99%

Large scale validation of a new non-invasive and non-contact bilirubinometer in neonates with risk factors

Halder

Adhikari

Ghosh

et al. 2020

Sci Rep

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The study was aimed to evaluate the performance of a newly developed non-invasive and noncontact bilirubin measurement device (AJo-neo) as an alternative to the conventional invasive biochemical method of total serum bilirubin (TSB) estimation in preterm and term neonates suffering from hyperbilirubinemia associated with risk factors, and/or undergoing phototherapy. The safety and efficacy of the device were assessed in 1968 neonates with gestational ages ranging from 28 to 41 weeks and suffering from incidences of hyperbilirubinemia. Linear regression analysis showed a good correlation between AJO-Neo and the conventional method of TSB (Pearson's coefficient, r = 0.79). The small bias (0.27 mg/dL) and limits of agreements (− 3.44 to 3.99 mg/dL) were within the range of clinical acceptance. The device was also precise in the measurement of bilirubin levels in all subgroups of the study. The receiver operator curve (ROC), that takes account of both sensitivity and specificity of a device showed high efficacy of the device (area under the curve, AUC = 0.83) in the detection of bilirubin. While monitoring the bilirubin level during phototherapy, the device indicated promising results showing good agreement with TSB. Specificities and sensitivities of the device indicated a much higher accuracy in neonates with associated risk factors for hyperbilirubinemia. Hence, the newly developed device (AJO-Neo) is reliable in measuring bilirubin level in preterm, and term neonates irrespective of gestational or postnatal age, sex, risk factors, feeding behavior or skin color. Neonatal jaundice or Icterus neonatorum affects more than 60% of the term and 80% of preterm newborns in the first week of life 1-3 due to excessive production of bilirubin, and the inability of the newly developed liver to excrete it 4. Although benign at low concentrations, persistently elevated levels of bilirubin can cause severe neurotoxicity termed as kernicterus, which may lead to significant morbidity and mortality 5,6. Thus, proper monitoring of the bilirubin level in newborns is mandatory as per the guideline of American Academy of Pediatrics (AAP) to ensure appropriate management 7. The contemporary method of detection of serum bilirubin

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Section: Discussionmentioning

confidence: 99%

Large scale validation of a new non-invasive and non-contact bilirubinometer in neonates with risk factors

Halder

Adhikari

Ghosh

et al. 2020

Sci Rep

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“…Forehead and sternum are the most commonly reported measurement sites, [11][12][13][14] performance of the bilirubinometer in other body sites after phototherapy has not been evaluated. The aim of this prospective study was to provide the missing data on the accuracy of the device in term Caucasian newborn infants who underwent phototherapy, considering four different measurement sites (exposed and unexposed) and two different modalities of phototherapy.…”

Section: Introductionmentioning

confidence: 99%

Accuracy of transcutaneous bilirubin measurement in newborns after phototherapy

et al. 2016

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“…Study by Chawla et al in 256 preterm neonates of <35 weeks GA for all 3 sites showed good correlation on forehead followed by abdomen and then sternum (r = 0.84, 0.72 and 0.83) 4 . Similar observations have been made by Kurokawa et al in VLBW neonates 5 .…”

Section: Discussionmentioning

confidence: 85%

Transcutaneous bilirubinometry: Influence of gestational age and measurement site

Vasava

Dagli

2018

Sri Lanka J Child Health

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Accuracy of transcutaneous bilirubin measurement in preterm low-birth-weight neonates

Abstract: TcB has good correlation and agreement with STB in preterm low-birth-weight neonates born at ≥28 weeks of gestation.

Cited by 24 publications

References 28 publications

Large scale validation of a new non-invasive and non-contact bilirubinometer in neonates with risk factors

Large scale validation of a new non-invasive and non-contact bilirubinometer in neonates with risk factors

Accuracy of transcutaneous bilirubin measurement in newborns after phototherapy

Transcutaneous bilirubinometry: Influence of gestational age and measurement site

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