Accuracy of Tumor Size Measurements Performed by Magnetic Resonance, Ultrasound and Mammography, and Their Correlation With Pathological Size in Primary Breast Cancer

Cuesta, Ana Belén Cuesta; Ríos, María Dolores Martín; Meseguer, M. Rosario Noguero; Velasco, Juan Antonio García; Martínez, María de Matías; Sotillos, Sara Bartolomé; Griego, Eduardo Abreu

doi:10.1016/j.cireng.2019.08.001

Cited by 14 publications

(10 citation statements)

References 28 publications

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“…Although CE-MRI exhibits higher sensitivity than mammography in the detection of DCIS, 13 calcifications in CE-MRI cannot be directly visualized, as only the active part of the tumor takes up contrast media; as a consequence, the concomitant evaluation of mammography is frequently performed to depict a possible peritumoral DCIS. Our results point out that the measured size of the contrast enhancing part of the tumor has a strong and significant correlation to the after measured size of the invasive component in the histological workup similar to MRI studies, where in clinical practice the tumor previously of surgery is measured to have an approximate idea of how much tissue has to be removed 14,15 …”

Section: Discussionsupporting

confidence: 60%

“…in clinical practice the tumor previously of surgery is measured to have an approximate idea of how much tissue has to be removed. 14,15 In most of the cases, also the size of the peritumoral DCIS measured in B-CT correlated strong with the size afterward measured in the histological workup. Nevertheless, in our small cohort, the values showed to be not significant as some of the peritumoral DCIS did not have perifocal microcalcifications in B-CT, which could have indicated its presence.…”

Section: Discussionmentioning

confidence: 60%

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Contrast Media–Enhanced Breast Computed Tomography With a Photon-Counting Detector

et al. 2022

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ObjectivesThe aim of this study was to investigate the feasibility, the image quality, and the correlation with histology of dedicated spiral breast computed tomography (B-CT) equipped with a photon-counting detector in patients with suspicious breast lesions after application of iodinated contrast media.Materials and MethodsThe local ethics committee approved this prospective study. Twelve women with suspicious breast lesions found in mammography or B-CT underwent contrast-enhanced spiral B-CT and supplementary ultrasound. For all lesions, biopsy-proven diagnosis and histological workup after surgical resection were obtained including the size of cancer/ductal carcinoma in situ, which were correlated to sizes measured in B-CT. Signal-to-noise ratio and contrast-to-noise ratio were evaluated for tumor, glandular tissue, and fatty tissue.ResultsOf the 12 patients, 15 suspicious lesions were found, 14 were malignant, and 1 benign lesion corresponded to a chronic inflammation. All lesions showed strong contrast media uptake with a signal-to-noise ratio of 119.7 ± 52.5 with a contrast-to-noise ratio between glandular tissue and breast cancer lesion of 12.6 ± 5.9. The correlation of the size of invasive tumors measured in B-CT compared with histological size was significant and strong R = 0.77 (P < 0.05), whereas the correlation with the size of the peritumoral ductal carcinoma in situ was not significant R = 0.80 (P = 0.11).ConclusionsContrast-enhanced B-CT shows high contrast between breast cancer and surrounding glandular tissue; therefore, it is a promising technique for cancer detection and staging depicting both soft tissue lesions and microcalcifications, which might be a substantial advantage over breast MRI.

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Section: Discussionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 60%

Contrast Media–Enhanced Breast Computed Tomography With a Photon-Counting Detector

et al. 2022

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“…Magnetic resonance imaging (MRI) is increasingly used for the diagnosis, therapy planning and follow-up of UM [7] , [15] , [16] , [17] , [18] , [19] , [20] . Various studies suggest that MRI’s 3D tumour visualisation and better tissue contrast might be beneficial in determining UM tumour dimensions compared to conventional 2D ultrasound, corresponding to findings in other malignancies [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] . Nevertheless, several uncertainties in MR-based dimensions measurements for ocular tumours remain that hinder broader application of MRI in ocular radiotherapy planning, for example regarding the optimal method to measure in 3D and the differences related to the various MRI contrasts.…”

Section: Introductionmentioning

confidence: 99%

Automatic Three-Dimensional Magnetic Resonance-based measurements of tumour prominence and basal diameter for treatment planning of uveal melanoma

Klaassen

Jaarsma-Coes

Verbist

et al. 2022

Physics and Imaging in Radiation Oncology

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“…This finding is important because this information affects the T feature of TNM classification and consequently changes therapeutic management. ( 22 )…”

Section: Discussionmentioning

confidence: 99%

Multimodality imaging in lobular breast cancer: Differences in mammography, ultrasound, and MRI in the assessment of local tumor extent and correlation with molecular characteristics

Dołęga-Kozierowski

Lis²,

Marszalska-Jacak

et al. 2022

Front. Oncol.

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IntroductionInvasive lobular breast cancer (ILC) is a diagnostic challenge due to the diversity of morphological features. The objective of the study was to investigate the presentation and local extent of ILC using various imaging techniques and to assess the correlation between imaging and molecular profile.Materials and methodsWe reviewed 162 consecutive patients with ILC found on vacuum-assisted biopsy, who underwent evaluation of the lesion morphology and extent using ultrasound (US), mammography (MMG), and magnetic resonance imaging (MRI). Radiographic features were compared with ILC intrinsic subtype based on the expression of Ki-67 and estrogen, progesterone, and HER2 receptors.ResultsA total of 113 mass lesions and 49 non-mass enhancements (NMEs) were found in MRI. Masses were typically irregular and spiculated, showing heterogeneous contrast enhancement, diffusion restriction, and type III enhancement curve. NMEs presented mainly as the area of focal or multiregional distribution with heterogeneous or clumped contrast enhancement, diffusion restriction, and type III enhancement curve. Lesion extent significantly varied between MRI and MMG/ultrasonography (USG) (P < 0.001) but did not differ between MGF and ultrasonography (USG). The larger the ILC, the higher the disproportion when lesion extent in MRI was compared with MMG (P < 0.001) and ultrasonography (USG) (P < 0.001). In the study group, there were 97 cases of luminal A subtype (59.9%), 54 cases of luminal B HER2− (33.3%), nine cases of luminal B HER2+ (5.5%), and two cases of triple negative (1.2%). The HER2 type was not found in the study group. We did not observe any significant correlation between molecular profile and imaging.ConclusionMRI is the most effective technique for the assessment of ILC local extent, which is important for optimal treatment planning. Further studies are needed to investigate if the intrinsic subtype of ILC can be predicted by imaging features on MRI.

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Accuracy of Tumor Size Measurements Performed by Magnetic Resonance, Ultrasound and Mammography, and Their Correlation With Pathological Size in Primary Breast Cancer

Cited by 14 publications

References 28 publications

Contrast Media–Enhanced Breast Computed Tomography With a Photon-Counting Detector

Contrast Media–Enhanced Breast Computed Tomography With a Photon-Counting Detector

Automatic Three-Dimensional Magnetic Resonance-based measurements of tumour prominence and basal diameter for treatment planning of uveal melanoma

Multimodality imaging in lobular breast cancer: Differences in mammography, ultrasound, and MRI in the assessment of local tumor extent and correlation with molecular characteristics

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