ObjectivesThe aim of this in vitro study was to evaluate the effect of arch size and implant angulation on the accuracy of digital impression in two intraoral scanners of Trios (3shape) and CEREC (Omnicam).Material and MethodsFour acrylic models each including six implants at sites 11, 12, 15, 17, 23, and 27 were used, including large with parallel implants, large with angled implants, small with parallel implants, and small with angled implants. After tightening the scan bodies, distance measurements were done using a coordinate measuring machine. Then, each model was scanned 10 times using each scanner. Trueness and precision measurements were finally computed.ResultsThe trueness values ranged from 20 to 260 μm in CEREC Omnicam, and from 40 to 1030 μm in Trios. The precision values ranged from 30 to 190 μm in CEREC Omnicam, while from 50 to 770 μm in Trios. The multivariate test analysis indicated that the measured distances via two scanners and different models show different behaviors. Pairwise interactions between these three variables were significant (p < .05). Pairwise interactions between these variables were also significant. (p < .0001).ConclusionsArch width could affect the accuracy of digital impression; by rotating toward the second quadrant and end points of the scan, errors have increased. However, the angulation of the implants had no effect on the accuracy of digital impression. The CEREC Omnicam scanner showed higher accuracy (trueness and precision) compared to the Trios (3shape) one.