International audienceIn the context of mission-critical, safety-critical, and remote-controlled applications, it is required to equip systems with self-adapting capabilities. Adaptation is required in post-manufacturing to correct yield loss and achieve zero defective parts-per-million as well as during normal operation to account for different application scenarios and for varying environmental conditions. A self-adaptive system must be capable of providing the required high performances after manufacturing and throughout its normal operation regardless the application scenario wherein it is deployed and despite the varying environmental conditions. In this paper, we describe a generic post-manufacturing self-adaptation technique for RF circuits as well as concurrent self-adaptation techniques for a safety-critical medical sensor for glaucoma diagnosis and for a NFC system which is very sensitive to the environment in which it operates