Accurate Assessment of Adherence

Daniels, T.; Goodacre, Lynne; Sutton, Chris J; Pollard, K.; Conway, S.P.; Peckham, Daniel

doi:10.1378/chest.09-3074

Cited by 185 publications

(92 citation statements)

References 22 publications

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“…1 Self-reported adherence consistently overestimates adherence when compared to objectively measured. 2, 3 Consequently, being a false positive self-reported adherer (i.e. being classified as adherent based on self-report and as non-adherent based on a more objective measurement) is a common occurrence.…”

Section: Introductionmentioning

confidence: 99%

“…being classified as adherent based on self-report and as non-adherent based on a more objective measurement) is a common occurrence. 2, 3 For instance, in a study among hypertensive patients on a single-drug therapy, the frequency of non-adherence was 21% when measured by self-report and 42% when measured with electronic cap bottles (i.e. missed ≥1 doses in >1 day/week).…”

Section: Introductionmentioning

confidence: 99%

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Factors associated with false-positive self-reported adherence to antihypertensive drugs

Tedla

Bautista²

2016

J Hum Hypertens

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Self-reported medication adherence is known to overestimate true adherence. However, little is known about patient factors that may contribute to the upward bias in self-reported medication adherence. The Objective of this study is to examine whether demographic, behavioral, medication, and mood factors are associated with being a false positive self-reported adherer (FPA) to antihypertensive drug treatment. We studied 175 patients (mean age: 50 years; 57% men) from primary care clinics starting antihypertensive drug treatment. Self-reported adherence was measured with the medication adherence report scale (MARS) and by the number of drug doses missed in the previous week/month and compared to pill count adherence (PCAR) as gold standard. Data on adherence, demographic, behavioral, medication, and mood factors were collected at baseline and every three months up to 1 year. FPA was defined as being non-adherer by PCAR and adherer by self-report. Mixed effect logistic regression was used for the analysis. Twenty percent of participants were FPA. Anxiety increased (odds ratio -OR: 3.00; P=0.01), while smoking (OR: 0.40; P=0.03), and drug side effects (OR: 0.46, P=0.03) decreased the probability for FPA by MARS. An educational below completed high school increased the probability of being a FPA as measured by missing doses in the last month (OR: 1.66; P=0.04) and last week (OR: 1.88; P=0.02). The validity of self-reported adherence varies significantly according to drug side effects, behavioral factors, and patient’s mood. Careful consideration should be given to the use of self-reported measures of adherence among patients likely to be false-positive adherers.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Factors associated with false-positive self-reported adherence to antihypertensive drugs

Tedla

Bautista²

2016

J Hum Hypertens

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“…Kettler et al (2002) suggest that an increase in disease severity may be associated with a decrease in adherence. However, Abbott et al (1994) found no association between disease severity and adherence in an earlier study, and this was confirmed by Daniels et al (2011) using electronic monitoring data. A concomitant increase in psychological distress may also account for a reduction in adherence (Kilbourne, 2005;Sundbom & Bingefors, 2013).…”

Section: Introductionmentioning

confidence: 77%

“…As self-reported measures often inflate rates of adherence, there is a need to investigate methodologies that are accurate and reliable O'Donohoe & Fullen, 2014). Electronic data collection methods, for instance nebulisers which directly record adherence to nebulised treatment (Daniels et al, 2011), are the "gold standard", but this technology cannot currently be used to assess adherence to tablet treatments and chest physiotherapy. One methodology which attempts to address some of these limitations is the Daily Phone Diary (DPD).…”

Section: Introductionmentioning

confidence: 99%

A weekend/weekday comparison of adherence to daily treatment regimens in adults with cystic fibrosis

Keyte¹,

Egan²,

Jackson³

et al. 2017

Health Psychology Report

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Treatment adherence is a major concern in cystic fibrosis (CF), with accumulating evidence that health outcomes are worse in patients with lower levels of adherence. This study investigates how adherence differs for adults with CF during a weekday and a weekend day by examining the roles of sex, anxiety, depression, and lung function as predictors of adherence. participants and procedureFifty-two adult participants with CF were recruited. Demographics and spirometry results were recorded. Participants completed the Hospital Anxiety and Depression Scale and two daily phone diaries in order to record their adherence to pancreatic enzymes, vitamins, physiotherapy and exercise. Based on previous findings, it was hypothesised that reported adherence would be higher during the weekend in comparison to weekdays, due to lower time pressure during the weekend. resultsPaired sample t-tests indicated that overall participants had higher reported adherence during the weekend in comparison to weekdays, with sex, anxiety, depression and lung function being predictors of adherence.conclusions Clinical implications and future directions are discussed, with an emphasis on the need for further qualitative research. We are now conducting another research project utilising qualitative interviews with participants to further investigate adherence within the CF population. Our aim is to identify the main adherence barriers and to develop interventions to improve treatment adherence in the CF population.

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“…It is clear that, above all other therapies, nebulised therapy is the most burdensome to patients [27], and that overall adherence to nebulised antibiotic therapies is low. In one study, in which adherence was monitored electronically, a median adherence at 35% was shown [36]. …”

Section: Chronic Suppressive Inhaled Antibiotic Therapymentioning

confidence: 99%

Inhaled Interventions in Cystic Fibrosis: Mucoactive and Antibiotic Therapies

Hurt¹,

Bilton²

2014

Respiration

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Treatment of cystic fibrosis lung disease has developed from an understanding of the abnormal airway surface liquid resulting from a lack of function of the cystic fibrosis transmembrane regulator protein. Mucus plugging resulting in infection and inflammation leads to airway wall destruction and bronchiectasis. Inhaled therapies have formed the backbone of treatments. In combination with antibiotics delivered direct to the airway, mucoactive drugs, including mucolytics and hyperosmolar agents, are utilised to improve mucociliary clearance to reduce infection and inflammation. Until recently, airway therapies were delivered as nebulisers, but we have now entered the era of dry powder inhalers for treatment of cystic fibrosis lung disease. The theory and practice of these therapies are discussed in this review.

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Accurate Assessment of Adherence

Cited by 185 publications

References 22 publications

Factors associated with false-positive self-reported adherence to antihypertensive drugs

Factors associated with false-positive self-reported adherence to antihypertensive drugs

A weekend/weekday comparison of adherence to daily treatment regimens in adults with cystic fibrosis

Inhaled Interventions in Cystic Fibrosis: Mucoactive and Antibiotic Therapies

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