Accurate characterization of extravascular lung water in acute respiratory distress syndrome*

Berkowitz, David M.; Danai, Pajman A.; Eaton, S. Boyd; Moss, Marc; Martin, Greg S.

doi:10.1097/ccm.0b013e3181743eeb

Cited by 119 publications

(96 citation statements)

References 38 publications

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“…[11][12][13] Some studies in adults have reported an association between the rise in EVLW, the occurence of ARDS, and the mortality of patients with severe sepsis. 14,15 In the present study, EVLW elevation in the colloid group was smaller than in the crystalloid group (Table 3). The increase in lung capillary permeability in sepsis causes a shifting of fluid into the interstitial space, resulting in EVLW elevation.…”

Section: Discussion Evlw Elevation In the Colloid And Crystalloid Groupmentioning

confidence: 79%

The effects of colloids or crystalloids on acute respiratory distress syndrome in swine (<em>Sus scrofa</em>) models with severe sepsis: analysis on extravascular lung water, IL-8, and VCAM-1

Dewi¹,

Supriyatno²,

Madjid

et al. 2016

Med J Indones

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Dewi, et al. Effects of colloids or crystalloid on ARDS 33The effects of colloids or crystalloids on acute respiratory distress syndrome in swine (Sus scrofa) models with severe sepsis: analysis on extravascular lung water, IL-8, and VCAM-1 Keywords: ARDS, colloid, crystalloid, EVLW, sepsis ABSTRACTBackground: Acute respiratory distress syndrome (ARDS) is a fatal complication of severe sepsis. Due to its higher molecular weight, the use of colloids in fluid resuscitation may be associated with fewer cases of ARDS compared to crystalloids. Extravascular lung water (EVLW) elevation and levels of interleukin-8 (IL-8) and vascular cell adhesion molecule-1 (VCAM-1) have been studied as indicators playing a role in the pathogenesis of ARDS. The aim of the study was to determine the effects of colloid or crystalloid on the incidence of ARDS, elevation of EVLW, and levels of IL-8 and VCAM-1, in swine models with severe sepsis.Methods: This was a randomized trial conducted at the Laboratory of Experimental Surgery, School of Veterinary Medicine, IPB, using 22 healthy swine models with a body weight of 8 to 12 kg. Subjects were randomly allocated to receive either colloid or crystalloid fluid resuscitation. After administration of endotoxin, clinical signs of ARDS, EVLW, IL-8, and VCAM-1 were monitored during sepsis, severe sepsis, and one-and three hours after fluid resuscitation. Analysis of data using the Wilcoxon test, Kolmogorov-Smirnov test , Mann-Whitney test, unpaired t test. Results:Mild ARDS was more prevalent in the colloid group, while moderate ARDS was more frequent in the crystalloid group. EVLW elevation was lower in the colloid compared to the crystalloid group. There was no significant difference in IL-8 and VCAM-1 levels between the two groups. Conclusion:The use of colloids in fluid resuscitation does not decrease the probability of ARDS events compared to crystalloids. Compared to crystalloids, colloids are associated with a lower increase in EVLWI, but not with IL-8 or VCAM-1 levels.

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Section: Discussion Evlw Elevation In the Colloid And Crystalloid Groupmentioning

confidence: 79%

The effects of colloids or crystalloids on acute respiratory distress syndrome in swine (<em>Sus scrofa</em>) models with severe sepsis: analysis on extravascular lung water, IL-8, and VCAM-1

Dewi¹,

Supriyatno²,

Madjid

et al. 2016

Med J Indones

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“…По казано, что контроль динамики ВСВЛ в процессе лече ния уменьшает продолжительность ИВЛ и длитель ность пребывания больного в отделении реанимации, а также снижает летальность в группе больных с некар диогенным ОЛ. Повышение ИВСВЛ >10 мл/кг сопро вождается более чем 60% летальностью [19][20][21][22].…”

Section: индекс внесосудистой воды легких (ивсвл) и ин дексы проницаеunclassified

“…Результаты подобных исследо ваний можно трактовать либо как ошибки диагностики ОРДС (включение в группу больных без ОРДС больных с острым повреждением легких), либо как дефекты из мерения ИВСВЛ. Известно, что дилюционные методы имеют тенденцию к недооценке количества ВСВЛ при ОЛ вследствие неполного распределения термального индикатора в отечной жидкости, нарушений вентиляци онно перфузионных отношений, допущений в матема тическом аппарате PiCCO Plus [19][20][21][22][23][24].…”

Section: индекс внесосудистой воды легких (ивсвл) и ин дексы проницаеunclassified

Diagnosis of Acute Respiratory Distress Syndrome in Nosocomial Pneumonia

Kuzovlev

Мороз

Goloubev

et al. 2010

Semin Cardiothorac Vasc Anesth

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“…A severe complication of pneumonia is systemic spreading of the invading pathogen finally resulting in acute respiratory distress syndrome (ARDS), septic shock and sepsis [37][38][39]. A plethora of clinical studies has shown that pathogenesis of ARDS and sepsis include the influx of protein-rich fluid into the air spaces as a consequence of increased permeability of the blood-air barrier leading to fatal lung edema formation [40][41][42][43]. Experimental studies in animals and cultured cells strengthened the hypothesis that junctional disruption of the lung barrier significantly contributes to a deleterious outcome [44][45][46].…”

Section: Pneumoniamentioning

confidence: 99%