Accurate determination of iron, copper and zinc in human serum by isotope dilution analysis using double focusing ICP-MS

Muñiz, Cristina Sariego; Marchante-Gayón, Juan Manuel; Alonso, J. Ignacio García; Sanz‐Medel, Alfredo

doi:10.1039/a901751h

Cited by 56 publications

(42 citation statements)

References 25 publications

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“…Commonly, Zn is determined by atomic absorption spectrometry [13] and ICP-AES [14] or ICP-MS [15]. These approaches can be expensive, both in terms of infrastructure and resources [16] and in the requirement of highly trained staff for their application.…”

Section: Introductionmentioning

confidence: 99%

Anodic stripping voltammetric determination of zinc at a 3-D printed carbon nanofiber–graphite–polystyrene electrode using a carbon pseudo-reference electrode

Honeychurch

Rymansaib

Iravani

2018

Sensors and Actuators B: Chemical

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The application of a novel fully 3-D printed carbon nanofiber-graphite-polystyrene electrode has been investigated for the trace determination of Zn 2+ by differential pulse anodic stripping voltammetry. The possibility of utilising a carbon pseudo-reference electrode was found to be successful. The effect of accumulation potential and time were investigated and optimised. Using an accumulation potential of-2.9 V (vs. C) and an accumulation time of 75 s a single sharp anodic stripping peak was recorded exhibiting a linear response from 12.7 µg/L to 450 µg/L. The theoretical detection limit (3σ) was calculated as 8.6 µg/L. Using the optimised conditions a mean recovery of 97.8 %, (%CV = 2.0 %, n = 5) for a tap water sample fortified at 0.990 µg/mL was obtained indicating the method holds promise for the determination of Zn 2+ in such samples.

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Section: Introductionmentioning

confidence: 99%

Anodic stripping voltammetric determination of zinc at a 3-D printed carbon nanofiber–graphite–polystyrene electrode using a carbon pseudo-reference electrode

Honeychurch

Rymansaib

Iravani

2018

Sensors and Actuators B: Chemical

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“…In recent years, the development and application of multi‐collector inductively coupled plasma‐mass spectrometry (MC‐ICP‐MS) has enabled highly accurate determination of the isotopic compositions of metals such as copper, iron, zinc that cannot be precisely determined by traditional thermal ionisation mass spectrometry (Sariego Muniz et al . , Zhu et al . , , Archer and Vance , Dauphas et al .…”

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confidence: 99%

Development of Two New Copper Isotope Standard Solutions and their Copper Isotopic Compositions

Yuan

Bao

et al. 2016

Geostandard Geoanalytic Res

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and copper wire, were dissolved in 1000 ml Teflon® bottles, to result in 200 µg ml -1 stock solutions (hereafter referred to as NWU-Cu-A and NWU-Cu-B), and cryogenically stored. The Cu isotopic compositions of the two samples were determined in three different laboratories using multi-collector inductively coupled plasma-mass spectrometry, and the Cu isotopic compositions obtained from the standard-sample bracketing method were consistent within the two standard deviation (2s) range. The Cu isotopic compositions of the NWU-Cu-A and NWU-Cu-B standard solutions were δ 65 Cu = +0.91 ± 0.03‰ (2s, n = 42) and δ 65 Cu = -0.05 ± 0.03‰ (2s, n = 49), respectively, relative to the reference material NIST NBS 976.

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“…Vanhaecke et al used isotope dilution for the accurate determination of Cu in groundwater candidate reference materials and applied a mass resolution of 3000 to resolve the analyte signals from those of ArNa + and S-based molecular ions [19]. Sariego-Muñiz et al used isotope dilution at a mass resolution of 3000 for the accurate determination of transition metals in human serum [20]. Prohaska et al used their single-collector sector field ICPMS instrument for the determination of S isotope ratios [21].…”

Section: High Mass Resolutionmentioning

confidence: 99%

Overcoming spectral overlap in isotopic analysis via single- and multi-collector ICP?mass spectrometry

Vanhaecke

Moëns

2004

Analytical and Bioanalytical Chemistry

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For isotope ratio applications where an internal isotope ratio precision >0.05-0.1% relative standard deviation suffices, single-collector inductively coupled plasma mass spectrometry (ICPMS) is fit-for-purpose, but for detecting more subtle variations in the natural isotopic composition of a target element, only multi-collector ICPMS (MC-ICPMS) can compete with thermal ionization mass spectrometry (TIMS). While as a result of the extensive sample preparation (analyte isolation) preceding TIMS and the "softer" ionization in vacuum, spectral interferences only seldom occur with this technique, their occurrence is recognized to be the most important drawback of ICPMS. This paper discusses high mass resolution and chemical resolution in a collision or dynamic reaction cell as powerful and versatile means to overcome spectral overlap and illustrates how their introduction has led to a substantial extension of the application range of ICPMS for isotope ratio applications. High mass resolution is the most elegant and straightforward way to overcome the problem of spectral overlap. Offering the possibility to operate the mass analyzer at a higher mass resolution, while at the same time preserving the flat-topped or trapezoidal peak shape required for highly precise isotope ratio measurements, was a challenge for the manufacturers of MC-ICPMS instrumentation. It will be discussed how these apparently contradicting requirements could be fulfilled simultaneously and an overview of the current situation will be given. Chemical resolution in a collision or dynamic reaction cell is an alternative to high mass resolution for overcoming spectral overlap. Real-life examples will be given to illustrate how also this approach can be used to advantage in isotope ratio work. Despite the greater flexibility and straightforwardness of high mass resolution, some situations will be discussed where chemical resolution is to be preferred. Finally, some desires as to future instrumentation are formulated.

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Accurate determination of iron, copper and zinc in human serum by isotope dilution analysis using double focusing ICP-MS

Cited by 56 publications

References 25 publications

Anodic stripping voltammetric determination of zinc at a 3-D printed carbon nanofiber–graphite–polystyrene electrode using a carbon pseudo-reference electrode

Anodic stripping voltammetric determination of zinc at a 3-D printed carbon nanofiber–graphite–polystyrene electrode using a carbon pseudo-reference electrode

Development of Two New Copper Isotope Standard Solutions and their Copper Isotopic Compositions

Overcoming spectral overlap in isotopic analysis via single- and multi-collector ICP?mass spectrometry

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