Accurate estimation of diffusion coefficient for molecular identification in a complex background

Passerini Multicomponent Reactions Enabling Self-Reporting Photosensitive Tetrazole Polymers

“…Moreover, after the first folding step yielding P9, there are both folded and unfolded segments present in the polymer. Since the diffusion coefficient is highly dependent on the size, molecular weight and architecture, a rather broad diffusion behavior is observed for the investigated polymers with multiple diffusion coefficients. − On the other hand, the DLS results (Figure S14 in the SI) indicate decreased hydrodynamic diameters after each folding process, thus suggesting the intramolecular folding of P3 in a λ-orthogonal, self-reporting manner. Nevertheless, further research needs to be conducted to explore the folding behavior of this interesting new polymer class.…”