Accurate evaluation of QT interval in conscious rhesus monkeys (Macaca mulatta) by use of Holter ECG

Hassimoto, Masatoshi; Harada, Tsuyoshi; Kaga, Nobuhiko; Murano, Hiroyuki; Obata, Masaomi

doi:10.1054/jelc.2002.35846

Cited by 16 publications

(28 citation statements)

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“…Changes of QT and corrected QT (QTc120) were also tested following ECG analysis 1. For QT correction, we used the QTc120 formula [14].…”

Section: Ecg Analysismentioning

confidence: 99%

“…In such studies, ECG recording methods such as the Holter or telemetry system, which are used for non‐restrained animals, can hardly be applied, because it is favorable for the animals not to suffer any anesthesia or invasive operation. Previously, we described the advantages and disadvantages of the Holter system [14] and the telemetry system [12]. To apply the Holter system, the animals must be acclimated to wear a recorder holding jacket and be anesthetized for attaching the Holter recorder prior to ECG measurement.…”

Section: Introductionmentioning

confidence: 99%

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Changes in hematology, biochemical values, and restraint ECG of rhesus monkeys (Macaca mulatta) following 6‐month laboratory acclimation

Hassimoto

Harada

2004

J of Medical Primatology

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The aim of this study was to determine if 6-month acclimation would enable accurate evaluation of hematological, biochemical data, and ECG recorded under restraint for conscious rhesus monkeys of both sexes. Periodic evaluation of these parameters was made during the 6-month period of acclimation. The platelet count, alkaline phosphatase, glucose, and sodium levels significantly decreased, whereas creatinine increased, compared with pre-acclimation values. The heart rate was significantly reduced compared with pre-acclimation values. QT-RR relation followed the square root regression function, which means modification of Bazett's QTc formula can be applied even if the ECG is recorded under restraint. In conclusion, 6-month acclimation was effective for stabilizing the blood data and for allowing accurate evaluation of the ECG even under restraint. Current results show that an acclimation period at least 3 months may be necessary prior to using rhesus monkeys for chronic studies.

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“…Changes of QT and corrected QT (QTc120) were also tested following ECG analysis 1. For QT correction, we used the QTc120 formula [14].…”

Section: Ecg Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Changes in hematology, biochemical values, and restraint ECG of rhesus monkeys (Macaca mulatta) following 6‐month laboratory acclimation

Hassimoto

Harada

2004

J of Medical Primatology

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“…Os primatas em geral apresentam a anatomia cardíaca e vascular muito semelhante às dos seres humanos e tem sido utilizados há longa data como modelos animais experimentais para estudos cardiovasculares (Goldberg & Moberg 1985, Hassimoto et al 2002, Ludlage & Mansfield 2003.…”

Section: Introductionunclassified

“…Historicamente, os primeiros modelos experimentais para avaliação da fisiologia cardíaca foram os primatas do velho mundo, como exemplo o macaco rhesus (Macaca mulatta) (Goldberg & Moberg 1985) que ainda nos dias atuais é considerado um bom modelo experimental para avaliação eletrofisiológica (Hassimoto et al 2002). Todavia, sua baixa prolificidade, associada ao grande porte dos animais e às dificuldades de manejo, tornaram seu uso dispendioso.…”

Section: Introductionunclassified

Valores eletrocardiográficos em saguis-de-tufo-preto (Callithrix penicillata)

et al. 2013

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Pesq. Vet. Bras. 33(7):937-941, julho 2013 937 RESUMO.-O conhecimento de parâmetros cardíacos em animais modelo experimentais é essencial para a investigação médica comparativa. Nosso estudo teve como objetivo estabelecer parâmetros eletrocardiográficos e valores de referência para saguis-de-tufo-preto (Callithrix penicillata). Dezenove saguis-de-tufo-preto adultos saudáveis foram utilizados. Uma combinação de tiletamina e zolazepam foi empregada para contenção química antes da realização do exame eletrocardiográfico (ECG Knowledge of cardiac parameters in experimental animal models is essential for comparative medical research. Our study aimed to establish electrocardiographic parameters and reference values for marmosets (Callithrix penicillata). Nineteen healthy adult marmosets were used. A combination of tiletamine and zolazepam was used for chemical restrained before performing electrocardiography (ECG). A computerized ECG machine was used. Values of the ECG parameters were a mean heart rate of 264±74 beats/min, a variation MCA between 60° and -90°, a mean P wave duration of 34±6ms and amplitude of 0.132±0.051mV, a mean PR interval duration of 56±11ms, a mean QRS complex duration of 35±7ms and amplitude of 0.273±0.269mV, a mean QT interval duration 130±26ms, ST segment was isoelectric (13 animals) and with elevation (six animals) and a mean T wave amplitude of 0.19±0.083mV and positive. There was no significant difference between males and females. Thus, the electrocardiographic parameters obtained in our study in marmosets can be used as a reference values to in other future researches, providing researchers electrocardiographic parameters that contribute with the literature.INDEX TERMS: Primate, marmoset, Callithrix penicillata, cardiology, electrocardiography.

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“…A critical factor for optimal performance of jacket telemetry in NHPs is complete acclimation to the processes involved with ECG lead placement, jacketing (on and off), and dosing [35]. Jacket-based ECG monitoring (e.g., Holter system) of QTc prolongation risk also has been conducted in conscious rhesus monkeys, which further supports the use of this approach in the toxicology setting [36]. There are no reports, however, of jacket-based telemetry in marmosets, possibly because of the small size of these animals relative to external equipment requirements.…”

Section: Telemetric Approaches For Hemodynamics and Ecgmentioning

confidence: 85%

Functional Assessments in Nonhuman Primate Toxicology Studies to Support Drug Development

Valentin

Delaunois

Lainée

et al. 2015

The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment

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Accurate evaluation of QT interval in conscious rhesus monkeys (Macaca mulatta) by use of Holter ECG

Cited by 16 publications

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Changes in hematology, biochemical values, and restraint ECG of rhesus monkeys (Macaca mulatta) following 6‐month laboratory acclimation

Changes in hematology, biochemical values, and restraint ECG of rhesus monkeys (Macaca mulatta) following 6‐month laboratory acclimation

Valores eletrocardiográficos em saguis-de-tufo-preto (Callithrix penicillata)

Functional Assessments in Nonhuman Primate Toxicology Studies to Support Drug Development

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